Results 31 to 40 of about 21,756 (262)

Biology of primate relaxin: A paracrine signal in early pregnancy?

Reproductive Biology and Endocrinology, 2004
Relaxin is a peptide hormone that exerts numerous effects in a variety of tissues across a broad range of species. Although first identified more than 75 years ago interest in relaxin biology has waxed and waned over the years consistent with peaks and ...
Hayes Eric S
doaj   +1 more source

A prospective observational study of mycophenolate mofetil treatment in progressive diffuse cutaneous systemic sclerosis of recent onset. [PDF]

, 2012
OBJECTIVE: A prospective observational study of mycophenolate mofetil (MMF) treatment in patients with diffuse progressive cutaneous systemic sclerosis (SSc) of recent onset.
Jimenez, Sergio A., Lee, MD, Jason B., Mendoza, MD, Fabian A., Nagle, Sarah J.   +3 more
core   +3 more sources

Relaxin treatment stimulates the differentiation of mesenchymal stem cells into osteoblasts

Journal of Dental Sciences, 2023
Background/purpose: Several studies have determined that relaxin stimulates differentiation and regulates the activity of mature osteoclasts, but little is known about its effect on the differentiation of mesenchymal cells towards the osteogenic lineage.
Lina M. Escobar, Zita Bendahan, Camilo Garcia, Jaime E. Castellanos   +3 more
doaj   +1 more source

Relaxin as a Therapeutic Target for the Cardiovascular Complications of Diabetes

Frontiers in Pharmacology, 2018
Cardiovascular complications are the major cause of mortality in patients with diabetes. This is closely associated with both macrovascular and microvascular complications of diabetes, which lead to organ injuries in diabetic patients.
Hooi Hooi Ng, Hooi Hooi Ng, Hooi Hooi Ng, Chen Huei Leo, Chen Huei Leo, Laura J. Parry, Rebecca H. Ritchie, Rebecca H. Ritchie   +7 more
doaj   +1 more source

Molecular Characteristics, Potential Mechanisms, and Prognostic Gene Model of Younger Female Patients With Gastric Cancer. [PDF]

Cancer Rep (Hoboken)
ABSTRACT Background Male patients were twice as likely to develop gastric cancer (GC) compared to females, partly due to the protective effect of estrogen. However, the proportion of females increased in the young GC patients. Aims The study was designed to explore comprehensive molecular profiles of younger female GC patients, as well as develop a ...
Luan X, Zhao L, Wang W, Niu P, Han X, Wang Z, Zhang X, Zhao D, Chen Y.   +8 more
europepmc   +2 more sources

Biological Pathways and Potential Targets for Prevention and Therapy of Chronic Allograft Nephropathy [PDF]

, 2014
Renal transplantation (RT) is the best option for patients with end-stage renal disease, but the half-life is limited to a decade due to progressive deterioration of renal function and transplant failure from chronic allograft nephropathy (CAN), which is
Haylor, John, Shrestha, Badri Man
core   +3 more sources

Evidence for a "Pro-relaxin" in Porcine Relaxin Concentrates

Experimental Biology and Medicine, 1977
SummaryFrom 5 to 10% of the biological activity of a porcine relaxin concentrate is contained in a fraction with a molecular weight which is considerably higher (∼42,000 daltons) than that of relaxin itself. Exposure of this material to a low concentration of trypsin results in the appearance of native relaxin, as judged by an increase in biological ...
E H, Frieden, L, Yeh
openaire   +2 more sources

Early drop in systolic blood pressure and worsening renal function in acute heart failure: renal results of Pre-RELAX-AHF. [PDF]

, 2011
AIMS: We aimed to determine the relation between baseline systolic blood pressure (SBP), change in SBP, and worsening renal function (WRF) in acute heart failure (AHF) patients enrolled in the Pre-RELAX-AHF trial.
Adriaan A. Voors, Barry H. Greenberg, Beth A. Davison, Elaine Unemori, G. Michael Felker, Gadi Cotter, Gerasimos Filippatos, John R. Teerlink, Marco Metra, null null, Piotr Ponikowski, Sam L. Teichman   +11 more
core   +5 more sources

Regulation of the reproductive cycle and early pregnancy by relaxin family peptides [PDF]

, 2014
The relaxin family of peptide hormones are structurally closely related to one another sharing a heterodimeric A–B structure, like that of insulin. They may also be active as unprocessed B–C–A pro-forms.
Adham, Amory, Anand-Ivell, Anand-Ivell, Anand-Ivell, Anand-Ivell, Anumba, Arroyo, Balvers, Bamberger, Bartsch, Bartsch, Bathgate, Bathgate, Bathgate, Bell, Blankenship, Bogatcheva, Braun, Brännström, Burnicka-Turek, Burnicka-Turek, Büllesbach, Conrad, Einspanier, Einspanier, Ferlin, Ferlin, Feugang, Feugang, Gambineri, Gellersen, Ghattas, Glister, Goldsmith, Granot, Guo, Halls, Halls, Hanna, Hansell, Havelock, Hayes, Heng, Hossain, Hsu, Hughes, Hwang, Irving-Rodgers, Ivell, Ivell, Ivell, Ivell, Ivell, Ivell, Jauniaux, Johnson, Kamat, Kawamura, Kim, Klonisch, Laurent, Lok, Luu, MacLennan, Maseelall, McGowan, McGuane, McMillen, Millar, Minagawa, Mita, Monk, Nef, Nguyen, Ohleth, Parry, Piccinni, Piccinni, Pusch, Ramathal, Ravinder Anand-Ivell, Richard Ivell, Rogers, Satchell, Segal, Sherwood, Shirota, Shirota, Silvertown, Siqin, Smith, Spanel-Borowski, Stewart, Stewart, Tang, Unemori, Unemori, Van Hiel, Vandevoort, Wathes, Wilson, Zimmermann   +102 more
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Immunoexpression of Relaxin and Its Receptors in Stifle Joints of Dogs with Cranial Cruciate Ligament Disease

Animals, 2022
The etiology of spontaneous cranial cruciate ligament rupture in dogs is unknown despite being one of the most impacting orthopedic diseases in dogs. Numerous studies have contributed to the understanding of a multifactorial pathogenesis, this, however ...
Brunella Restucci, Mariafrancesca Sgadari, Gerardo Fatone, Giovanni Della Valle, Federica Aragosa, Chiara Caterino, Gianmarco Ferrara, Gert W. Niebauer   +7 more
doaj   +1 more source