Results 51 to 60 of about 11,028 (173)

Relaxin-Family Peptide Receptors 1 and 2 Are Fully Functional in the Bovine

Frontiers in Physiology, 2017
In most mammals the peptide hormone relaxin is a key physiological component regulating early pregnancy and birth. However, synteny analysis shows that the gene encoding ovarian relaxin-2 is deleted in cows and sheep.
Yanzhenzi Dai, Yanzhenzi Dai, Richard Ivell, Richard Ivell, Richard Ivell, Xuan Liu, Dana Janowski, Ravinder Anand-Ivell, Ravinder Anand-Ivell   +8 more
doaj   +1 more source

Development of Relaxin-3 Agonists and Antagonists Based on Grafted Disulfide-Stabilized Scaffolds

Frontiers in Chemistry, 2020
Relaxin-3 is a neuropeptide with important roles in metabolism, arousal, learning and memory. Its cognate receptor is the relaxin family peptide-3 (RXFP3) receptor.
Han Siean Lee, Michael Postan, Angela Song, Richard J. Clark, Ross A. D. Bathgate, Ross A. D. Bathgate, Linda M. Haugaard-Kedström, K. Johan Rosengren   +7 more
doaj   +1 more source

Cellular delivery of relaxin-2 mRNA as a potential treatment for kidney fibrosis

Materials Today Bio, 2023
Renal fibrosis is a pathological feature of chronic kidney disease and its progression correlates with kidney function impairment. Since there are currently no specific therapies for renal fibrosis, we explored whether inducing local production of the ...
Chenguang Ding, Bo Wang, Xiang Feng Lai, Yingcong Guo, Greg Tesch, Xiaoming Ding, Jin Zheng, PuXun Tian, Sharon Ricardo, Hsin-Hui Shen, Wujun Xue   +10 more
doaj   +1 more source

Effects of Selenocysteine Substitution on the Cyclotide Kalata B2

ChemBioChem, Volume 27, Issue 18, 28 September 2026.
Selenocysteine (Sec) substitution of any of the native complementary cysteine (Cys) residues of the cyclotide kalata B2 preserves the structure, cytotoxicity, and membrane‐binding activity while enhancing its folding efficiency. The study shows the conservative nature and folding benefit of selenocysteine replacement in kalata B2.
Ramoncito Luis B. de Boda, Sónia Troeira Henriques, Yen‐Hua Huang, Christine C. Hernandez, Portia Mahal G. Sabido, David J. Craik   +5 more
wiley   +1 more source

Relaxin protects rat lungs from ischemia-reperfusion injury via inducible NO synthase: role of ERK-1/2, PI3K, and forkhead transcription factor FKHRL1.

PLoS ONE, 2013
IntroductionEarly allograft dysfunction following lung transplantation is mainly an ischemia/reperfusion (IR) injury. We showed that relaxin-2 (relaxin) exerts a protective effect in lung IR, attributable to decreases in endothelin-1 (ET-1) production ...
Konstantin Alexiou, Manuel Wilbring, Klaus Matschke, Thomas Dschietzig   +3 more
doaj   +1 more source

Effects of swimming exercise and RLN2 induction on relaxin levels, MMP-13, TGFβ expression in the pubic cartilage of pregnant rats [PDF]

Journal of Pharmacy & Pharmacognosy Research, 2022
Context: Swimming exercises can be used as an intervention to maintain the stability of the synthesis of the pubic symphysis cartilage. Aims: To evaluate the effects of swimming exercise on relaxin levels, MMP-13, TGFβ expression in pubic cartilage at
Ika Oktaviani, Titin Andri Wihastuti, Bambang Rahardjo, Endang Sri Wahyuni, Bilqisthi Ari Putra   +4 more
doaj  

The formation and stabilization of a novel G-quadruplex in the 5'-flanking region of the relaxin gene. [PDF]

PLoS ONE, 2012
It has been reported that binding of STAT3 protein to the 5'-flanking region of the relaxin gene may result in downregulation of the relaxin expression.
Sen Lin, Huiping Gu, Ming Xu, Xiaojie Cui, Youyi Zhang, Wei Gao, Gu Yuan   +6 more
doaj   +1 more source

Systemic Hormonal Contraceptive Use Is Associated With Greater Odds of Rotator Cuff Tears, Shoulder Instability, Dislocation, and Other Shoulder Pathologies: A Propensity Matched Epidemiological Study

Arthroscopy, Volume 42, Issue 9, Page 1529-1537, September 2026.
Purpose To evaluate whether systemic estrogen‐only, progestin‐only, or combined hormonal contraceptives (HCs) are associated with increased risk of shoulder pathologies in reproductive‐age females. Methods A retrospective cohort study of female patients presenting to clinic from 2013 to 2020 and aged 13‐50 with 5 years of follow‐up was conducted using ...
Argen Omurzakov, Arsen M. Omurzakov, Robert J. Burkhart, Aakash K. Shah, Rayyan Abid, James E. Voos, Jacob G. Calcei, John M. Apostolakos   +7 more
wiley   +1 more source

Potential therapeutic use of relaxin in accelerating closure of cranial bone defects in mice

Physiological Reports, 2019
Bone fractures are associated with considerable morbidity and increased mortality. A major limitation to healing is lack of bone blood flow, which is impaired by physical disruption of intraskeletal and/or periosteal vasculature by the fracture.
Kirk P. Conrad, Ean G. Phillips, Jessica Jiron, Julie Bailes, Biswadeep Dhar, YanPeng Diao, Jose Ignacio Aguirre, Joshua F. Yarrow   +7 more
doaj   +1 more source

Virtual single‐cell perturbation and genetic causal inference reveal CSF1R‐dependent immunometabolic communication in iron metabolism‐associated osteoarthritis

Journal of Cell Communication and Signaling, Volume 20, Issue 3, September 2026.
Integrative genetic, single‐cell, and perturbation analyses identify CSF1R as a macrophage‐centered immunometabolic signaling hub linking iron dysregulation to osteoarthritis. CSF1R‐driven monocyte–macrophage remodeling may coordinate immune activation, extracellular matrix remodeling, and cartilage degeneration, providing a potential therapeutic ...
Yue Zhou, Guohang Shen, Lijing Si, Kaiyong Wang, Yang Chen, Ruoyan Wang, Yupei Dai   +6 more
wiley   +1 more source