Results 61 to 70 of about 21,756 (262)

Peripartum cardiomyopathy: an update [PDF]

, 1991
Purpose of Review Peripartum cardiomyopathy (PPCM) is an idiopathic disorder defined as heart failure occurring in women during the last month of pregnancy and up to 5 months postpartum.
Azibani, Feriel, Sliwa-Hahnle, Karen
core   +6 more sources

The impact of breast milk relaxin 2, oxytocin, and insulin‐like peptide 3 on neonatal growth parameters in early life

Journal of Pediatric Gastroenterology and Nutrition, EarlyView.
Abstract Objectives This study aims to quantify the levels of relaxin 2 (RLX2), oxytocin (OXT), and insulin‐like peptide 3 (INSL3) in colostrum (postpartum days 1–5, Visit 1) and mature breast milk (postpartum days 21–35, Visit 2), and to evaluate their associations with neonatal growth outcomes.
Hakan Doneray, Ayse Ozden, Guzide Tavlas, Halil Ibrahim Ozkan   +3 more
wiley   +1 more source

Relaxin-2 Expression in Oral Squamous Cell Carcinoma

The International Journal of Biological Markers, 2016
Background When advanced, oral squamous cell carcinoma (OSCC) may involve adjacent non-epithelial structures, and the prognosis is worse for bone invasion. Human relaxin-2 is a peptide hormone that has recently been associated with cancer.
Gino Marioni MD, Roberto Di Carlo, Giancarlo Ottaviano, Rocco Cappellesso, Alberto Bedogni, Rosario Marchese-Ragona, Paola Stritoni, Marco Rossi, Elisabetta Zanoletti, Niccolò Favaretto, Elisa Valentini, Federico Apolloni, Luciano Giacomelli, Alessandro Martini, Stella Blandamura   +14 more
doaj   +1 more source

Development of Relaxin-3 Agonists and Antagonists Based on Grafted Disulfide-Stabilized Scaffolds

Frontiers in Chemistry, 2020
Relaxin-3 is a neuropeptide with important roles in metabolism, arousal, learning and memory. Its cognate receptor is the relaxin family peptide-3 (RXFP3) receptor.
Han Siean Lee, Michael Postan, Angela Song, Richard J. Clark, Ross A. D. Bathgate, Ross A. D. Bathgate, Linda M. Haugaard-Kedström, K. Johan Rosengren   +7 more
doaj   +1 more source

The formation and stabilization of a novel G-quadruplex in the 5'-flanking region of the relaxin gene. [PDF]

PLoS ONE, 2012
It has been reported that binding of STAT3 protein to the 5'-flanking region of the relaxin gene may result in downregulation of the relaxin expression.
Sen Lin, Huiping Gu, Ming Xu, Xiaojie Cui, Youyi Zhang, Wei Gao, Gu Yuan   +6 more
doaj   +1 more source

Cellular delivery of relaxin-2 mRNA as a potential treatment for kidney fibrosis

Materials Today Bio, 2023
Renal fibrosis is a pathological feature of chronic kidney disease and its progression correlates with kidney function impairment. Since there are currently no specific therapies for renal fibrosis, we explored whether inducing local production of the ...
Chenguang Ding, Bo Wang, Xiang Feng Lai, Yingcong Guo, Greg Tesch, Xiaoming Ding, Jin Zheng, PuXun Tian, Sharon Ricardo, Hsin-Hui Shen, Wujun Xue   +10 more
doaj   +1 more source

Novel Insights into the Bovine Polled Phenotype and Horn Ontogenesis in Bovidae [PDF]

, 2013
Despite massive research efforts, the molecular etiology of bovine polledness and the developmental pathways involved in horn ontogenesis are still poorly understood.
Allais-Bonnet, Aurélie, Barbey, Sarah, Baur, Aurélia, Bernard-Capel, Carine, Blum, Helmut, Boichard, Didier, Bouet, Stéphan, Boussaha, Mekki, Capitan, Aurélien, Catros, Olivier, Clément, Laetitia, Cobo, Emilie, Djari, Anis, Dozias, Dominique, Eggen, André, Elín Hreiðarsdóttir, Gunnfríður, Esquerré, Diane, Fouchet, Michel, Fouilloux, Marie-Noëlle, Fritz, Sébastien, Gallard, Yves, Graf, Alexander, Grohs, Cécile, Hoze, Chris, Journaux, Laurent, Klopp, Christophe, Krebs, Stefan, Le Bourhis, Daniel, Marchand, Jean-Luc, Marquant-Leguienne, Brigitte, Medugorac, Ivica, Pailhoux, Eric, Pannetier, Maëlle, Phocas, Florence, Ponsart, Claire, Reverse, Patrick, Rocha, Dominique, Rossignol, Marie-Noëlle, Rothammer, Sophie, Roy, Pierre, Russ, Ingolf, Salas-Cortes, Laura, Seichter, Doris, Soulas, Pascal, Thépot, Dominique, van Marle-Köster, Este, Venot, Eric, Wahlberg, Per, Weiss, Bernard   +48 more
core   +7 more sources

Cryptorchidism: Novel genetic insights into CCDC149 mutations

Andrology, EarlyView.
Abstract Background Cryptorchidism, characterized by the failure of one or both testes to descend into the scrotum, is a common congenital condition that can lead to infertility and increased risk of testicular cancer. CCDC149, a coiled‐coil domain‐containing protein, has been implicated in various developmental processes, but its role in the male ...
Shengrong Du, Shan Xu, Lei Yang, Yan Ye, Yuhan Wu, Ziyun Xiao, Xiuqing Dong, Wenliang Yao, Hua Li   +8 more
wiley   +1 more source

Relaxin protects rat lungs from ischemia-reperfusion injury via inducible NO synthase: role of ERK-1/2, PI3K, and forkhead transcription factor FKHRL1.

PLoS ONE, 2013
IntroductionEarly allograft dysfunction following lung transplantation is mainly an ischemia/reperfusion (IR) injury. We showed that relaxin-2 (relaxin) exerts a protective effect in lung IR, attributable to decreases in endothelin-1 (ET-1) production ...
Konstantin Alexiou, Manuel Wilbring, Klaus Matschke, Thomas Dschietzig   +3 more
doaj   +1 more source

In vitro pharmacological characterization of RXFP3 allosterism: an example of probe dependency. [PDF]

PLoS ONE, 2012
Recent findings suggest that the relaxin-3 neural network may represent a new ascending arousal pathway able to modulate a range of neural circuits including those affecting circadian rhythm and sleep/wake states, spatial and emotional memory, motivation
Lily Alvarez-Jaimes, Steven W Sutton, Diane Nepomuceno, S Timothy Motley, Miroslav Cik, Emily Stocking, James Shoblock, Pascal Bonaventure   +7 more
doaj   +1 more source