Results 61 to 70 of about 11,028 (173)

Rh-relaxin-2 attenuates oxidative stress and neuronal apoptosis via ERK-nNOS-NO pathway after germinal matrix hemorrhage in rats

Fluids and Barriers of the CNS
Oxidative stress and neuronal apoptosis could be an important factor leading to post-hemorrhagic consequences after germinal matrix hemorrhage (GMH). Previously study have indicated that relaxin 2 receptor activation initiates anti-oxidative stress and ...
Jun Liu, Yonghua Cai, Khalil ur Rahman, Qixiong Zhou, Guangjie Liu, Huibin Kang, Mingzhou Li, Shichao Zhang, Gang Wang, Wenfeng Feng, Xi’an Zhang, Guozhong Zhang, Ye Song, Peng Li   +13 more
doaj   +1 more source

Anti-Fibrosis Effect of Relaxin and Spironolactone Combined on Isoprenaline-Induced Myocardial Fibrosis in Rats via Inhibition of Endothelial–Mesenchymal Transition

Cellular Physiology and Biochemistry, 2017
Background: The effect of relaxin and spironolactone combined on myocardial fibrosis has not been reported. Thus, we investigated the effect of the combined therapy on isoprenaline-induced myocardial fibrosis and the mechanism.
Jiejie Cai, Xiao Chen, Xingxing Chen, Lingzhi Chen, Gaoshu Zheng, Hao Zhou, Xi Zhou   +6 more
doaj   +1 more source

In vitro pharmacological characterization of RXFP3 allosterism: an example of probe dependency. [PDF]

PLoS ONE, 2012
Recent findings suggest that the relaxin-3 neural network may represent a new ascending arousal pathway able to modulate a range of neural circuits including those affecting circadian rhythm and sleep/wake states, spatial and emotional memory, motivation
Lily Alvarez-Jaimes, Steven W Sutton, Diane Nepomuceno, S Timothy Motley, Miroslav Cik, Emily Stocking, James Shoblock, Pascal Bonaventure   +7 more
doaj   +1 more source

Age‐Associated Four‐Gene Prognostic Signature in Breast Cancer

Cancer Reports, Volume 9, Issue 9, September 2026.
ABSTRACT Background Young‐onset breast cancer is associated with inferior disease‐free survival (DFS), but the contribution of additional molecular heterogeneity remains unclear. Aims To identify an exploratory age‐associated gene expression signature linked to recurrence‐related outcomes and evaluate its prognostic association.
Shiro Uchida
wiley   +1 more source

Relaxin-3-deficient mice showed slight alteration in anxiety-related behavior

Frontiers in Behavioral Neuroscience, 2011
Relaxin-3 is a neuropeptide belonging to the relaxin/insulin superfamily. Studies using rodents have revealed that relaxin-3 is predominantly expressed in neurons in the nucleus incertus of the pons, the axons of which project to forebrain regions ...
Yoshihisa eWatanabe, Atsushi eTsujimura, Keizo eTakao, Kazunori eNishi, Yasuaki eIto, Yoshitaka eYasuhara, Yasuhito eNakatomi, Chihiro eYokoyama, Kenji eFukui, Tsuyoshi eMiyakawa, Masaki eTanaka   +10 more
doaj   +1 more source

Bushen Huatan Formula Ameliorates Early Chronic Low‐Grade Inflammation in Obese PCOS Via the TLR4/NF‐κB Signaling Pathway: An Integrated Network Pharmacology and Experimental Study

Immunity, Inflammation and Disease, Volume 14, Issue 9, September 2026.
ABSTRACT Objective This study used an integrated network pharmacology and experimental strategy to investigate how Bushen Huatan Formula (BHF) mitigates early‐stage chronic low‐grade inflammation in obese polycystic ovary syndrome (PCOS). Methods Candidate components and targets of BHF were retrieved from the TCMSP database, and protein–protein ...
Jianing Zhang, Fangyun Gu, Yunyun Li, Xiaoling Feng, Hongying Kuang, Fang Xu, Miao Sun   +6 more
wiley   +1 more source

Effect of relaxin on heart rate and relaxin serum concentration.

, 2016
(A) Rat relaxin was increased during pregnancy in transgenic and non-transgenic control rats. (B) Telemetrically measured heart rates. Relaxin treatment leads to an immediately increase in heart rate compared to vehicle treated rats.
Florian Herse (252632), Julianna Rugor (548251), Ralf Dechend (252651), Michaela Golic (2559895), Nadine Haase (202940), Maria Emilia Solano (2349949), Dominik Linz (2044288), Dominik N. Müller (2559898)   +7 more
core   +1 more source

Relaxin family peptides: structure-activity relationship studies [PDF]

, 2017
The human relaxin peptide family consists of seven cystine-rich peptides, four of which are known to signal through relaxin family peptide receptors, RXFP1-4.
John D Wade, K Johan Rosengren, Mohammed Akhter Hossain, Separovic, Frances, Frances Separovic, Separovic, F, Rosengren, KJ, Wade, John D., Wade, JD, Bathgate, RAD, Rosengren, K. Johan, Hossain, Mohammed Akhter, Patil, NA, Patil, Nitin A., Hossain, MA, Bathgate, Ross A. D., Nitin A Patil, Ross A D Bathgate   +17 more
core   +1 more source

Characterization of Lipizzan Horse Population From Lipica Stud Using Molecular and Pedigree Data

Animal Genetics, Volume 57, Issue 4, August 2026.
ABSTRACT In this study, we analysed genetic diversity, population structure and inbreeding in the Lipica Stud Farm population by integrating pedigree records, microsatellite (STR) and genome‐wide SNP data generated using the GGP Equine 70K BeadChip. The dataset comprised 233 horses from the Lipica Stud Farm, which served as the reference population for
Tamara Ferme, Minja Zorc, Marko Cotman, Matjaž Mesarič, Peter Dovč   +4 more
wiley   +1 more source

Relaxin-3 inputs target hippocampal interneurons and deletion of hilar relaxin-3 receptors in “floxed-RXFP3” mice impairs spatial memory

, 2017
Relaxin-3 inputs target hippocampal interneurons and deletion of hilar relaxin-3 receptors in “floxed-RXFP3” mice impairs spatial ...
RAD Bathgate (14876653), E Timofeeva (13357596), G Guèvremont (13357590), M Haidar (13357587), AL Gundlach (14448708), Craig Smith (13065255), C Zhang (2567170)   +6 more
core