Results 71 to 80 of about 21,756 (262)
Dehnel's Phenomenon in Mammals
Mammal Review, Volume 56, Issue 2, June 2026.Some small mammals, which remain active year‐round, undergo reversible reductions in body size, braincase height, and the mass of internal organs, including the brain, from summer to winter. It is called Dehnel's phenomenon. In this review, we summarise knowledge of the mechanisms, adaptive value, and genetic basis of the phenomenon, and show how new ...
Jan R. E. Taylor +2 more
wiley +1 more source
Effects of swimming exercise and RLN2 induction on relaxin levels, MMP-13, TGFβ expression in the pubic cartilage of pregnant rats [PDF]
Journal of Pharmacy & Pharmacognosy Research, 2022 Context: Swimming exercises can be used as an intervention to maintain the stability of the synthesis of the pubic symphysis cartilage. Aims: To evaluate the effects of swimming exercise on relaxin levels, MMP-13, TGFβ expression in pubic cartilage at
Ika Oktaviani +4 more
doaj
Supplementary Figure Legend from Relaxin-Expressing, Fiber Chimeric Oncolytic Adenovirus Prolongs Survival of Tumor-Bearing Mice [PDF]
, 2023 Shanthi Ganesh +7 more
openalex +1 more source
Targeting Tumor Stroma: Current Challenges and Future Directions
MedComm, Volume 7, Issue 5, May 2026.Figure 1. Mechanism of ECM reprogramming. Cancer‐associated fibroblasts (CAFs), cancer‐associated macrophages (CAMs), and other mesenchymal cells alter the ECM composition and increase its stiffness by depositing matrix components such as collagen and hyaluronic acid, and secreting cross‐linking agents like lysyl oxidase homolog 2 (LOXL2).
Siwei Wang +7 more
wiley +1 more source
Potential therapeutic use of relaxin in accelerating closure of cranial bone defects in mice
Physiological Reports, 2019 Bone fractures are associated with considerable morbidity and increased mortality. A major limitation to healing is lack of bone blood flow, which is impaired by physical disruption of intraskeletal and/or periosteal vasculature by the fracture.
Kirk P. Conrad +7 more
doaj +1 more source
Relaxin-Family Peptide Receptors 1 and 2 Are Fully Functional in the Bovine
Frontiers in Physiology, 2017 In most mammals the peptide hormone relaxin is a key physiological component regulating early pregnancy and birth. However, synteny analysis shows that the gene encoding ovarian relaxin-2 is deleted in cows and sheep.
Yanzhenzi Dai +8 more
doaj +1 more source
Advancing the Landscape of RNAi Nanotherapeutics for Ischemic Heart Disease
Advanced Materials, Volume 38, Issue 17, 20 March 2026.RNA interference (RNAi) nanomedicine revolutionizes treatment regimens for ischemic heart diseases by enabling tailored, sequence‐anchored gene regulation. This review highlights the recent advances in nanotechnology‐driven RNAi therapeutics for myocardial ischemia and discusses the key design principles that govern efficient delivery, providing ...
Han Gao, Da Pan, Hélder A. Santos
wiley +1 more source
Cellular Physiology and Biochemistry, 2017 Background: The effect of relaxin and spironolactone combined on myocardial fibrosis has not been reported. Thus, we investigated the effect of the combined therapy on isoprenaline-induced myocardial fibrosis and the mechanism.
Jiejie Cai +6 more
doaj +1 more source
Advanced Science, Volume 13, Issue 14, 9 March 2026.A mechanically robust, ROS‐responsive hydrogel is engineered to treat intervertebral disc degeneration by targeting the NF‐κB–LCN2 inflammatory feedback loop. By delivering wedelolactone specifically within oxidative niches, this system disrupts macrophage–disc cell crosstalk.
Zimei Wu +10 more
wiley +1 more source
Relaxin-3-deficient mice showed slight alteration in anxiety-related behavior
Frontiers in Behavioral Neuroscience, 2011 Relaxin-3 is a neuropeptide belonging to the relaxin/insulin superfamily. Studies using rodents have revealed that relaxin-3 is predominantly expressed in neurons in the nucleus incertus of the pons, the axons of which project to forebrain regions ...
Yoshihisa eWatanabe +10 more
doaj +1 more source