Results 1 to 10 of about 7,229 (129)

Relaxin-2 plasma levels in atrial fibrillation are linked to inflammation and oxidative stress markers [PDF]

Scientific Reports, 2022
Relaxin-2 exerts many favourable cardiovascular effects in pathological circumstances such as atrial fibrillation (AF) and heart failure, but the mechanisms underlying its actions are not completely understood. Since inflammation and fibrosis are pivotal
Alana Aragón-Herrera, Marinela Couselo-Seijas, Sandra Feijóo-Bandín, Laura Anido-Varela, Sandra Moraña-Fernández, Estefanía Tarazón, Esther Roselló-Lletí, Manuel Portolés, José Luis Martínez-Sande, Javier García-Seara, Ezequiel Álvarez, José Ramón González-Juanatey, Moisés Rodríguez-Mañero, Sonia Eiras, Francisca Lago   +14 more
doaj   +2 more sources

Cellular delivery of relaxin-2 mRNA as a potential treatment for kidney fibrosis [PDF]

Materials Today Bio, 2023
Renal fibrosis is a pathological feature of chronic kidney disease and its progression correlates with kidney function impairment. Since there are currently no specific therapies for renal fibrosis, we explored whether inducing local production of the ...
Chenguang Ding, Bo Wang, Xiang Feng Lai, Yingcong Guo, Greg Tesch, Xiaoming Ding, Jin Zheng, PuXun Tian, Sharon Ricardo, Hsin-Hui Shen, Wujun Xue   +10 more
doaj   +2 more sources

Relaxin-2: Shaping the Proteomic Landscape of Skeletal Muscle Physiology, Glucose Trafficking, and Mitochondrial Function in Rat. [PDF]

FASEB J
Cardioprotective hormone relaxin‐2 showed relevant effects on rat skeletal muscle by altering proteins linked to muscle function, regeneration, differentiation, mitochondrial function, glucose metabolism, and structural integrity and organization. Specifically, relaxin‐2 reduced the expression of 95 proteins, increased 32, and elicited unique proteins ...
Vázquez-Abuín X, Gómez-Cibeira L, García-Seara J, de la Fuente-López P, Minguito-Carazo C, Bravo SB, Otero-Santiago M, Gualillo O, González-Juanatey JR, Lago F, Feijóo-Bandín S, Aragón-Herrera A.   +11 more
europepmc   +2 more sources

Rh-relaxin-2 attenuates oxidative stress and neuronal apoptosis via ERK-nNOS-NO pathway after germinal matrix hemorrhage in rats [PDF]

Fluids and Barriers of the CNS
Oxidative stress and neuronal apoptosis could be an important factor leading to post-hemorrhagic consequences after germinal matrix hemorrhage (GMH). Previously study have indicated that relaxin 2 receptor activation initiates anti-oxidative stress and ...
Jun Liu, Yonghua Cai, Khalil ur Rahman, Qixiong Zhou, Guangjie Liu, Huibin Kang, Mingzhou Li, Shichao Zhang, Gang Wang, Wenfeng Feng, Xi’an Zhang, Guozhong Zhang, Ye Song, Peng Li   +13 more
doaj   +2 more sources

Rh-relaxin-2 attenuates degranulation of mast cells by inhibiting NF-κB through PI3K-AKT/TNFAIP3 pathway in an experimental germinal matrix hemorrhage rat model [PDF]

Journal of Neuroinflammation, 2020
Background Mast cells play an important role in early immune reactions in the brain by degranulation and the consequent inflammatory response. Our aim of the study is to investigate the effects of rh-relaxin-2 on mast cells and the underlying mechanisms ...
Peng Li, Gang Zhao, Fanfan Chen, Yan Ding, Tianyi Wang, Shengpeng Liu, Weitian Lu, Weilin Xu, Jerry Flores, Umut Ocak, Tongyu Zhang, John H. Zhang, Jiping Tang   +12 more
doaj   +2 more sources

Circular RNA encoding relaxin-2 as a potential therapy for liver fibrosis [PDF]

Molecular Therapy: Nucleic Acids
Circular RNAs (circRNAs) have recently emerged as a promising new drug modality with significant therapeutic potential due to their higher stability and lower immunogenicity.
Jiewen Zhong, Zheyu Zhang, Lixing Xiao, Cheng Wang, Yun Yang, Qinghao Zhang, Zefeng Wang   +6 more
doaj   +2 more sources

Human Relaxin‐2 Fusion Protein Treatment Prevents and Reverses Isoproterenol‐Induced Hypertrophy and Fibrosis in Mouse Heart [PDF]

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2019
Background Heart failure is one of the leading causes of death in Western countries, and there is a need for new therapeutic approaches. Relaxin‐2 is a peptide hormone that mediates pleiotropic cardiovascular effects, including antifibrotic, angiogenic ...
Junhui Sun, Weidong Hao, Natasha Fillmore, Hanley Ma, Danielle Springer, Zu‐Xi Yu, Agnieszka Sadowska, Andrew Garcia, Ruoyan Chen, Vanessa Muniz‐Medina, Kim Rosenthal, Jia Lin, Denison Kuruvilla, Jane Osbourn, Sotirios K. Karathanasis, Jill Walker, Elizabeth Murphy   +16 more
doaj   +2 more sources

Relaxin-2-secreting CAR-T cells exhibit enhanced efficacy in stromal-rich xenograft tumors [PDF]

Frontiers in Immunology
IntroductionChimeric antigen receptor (CAR)-T cell therapy has demonstrated notable efficacy in treating hematological malignancies. Although it has shown promise in the clinical management of solid tumors, poor outcomes in clinical trials highlight the ...
Hisataka Ogawa, Tomoya Ekawa, Yu Mizote, Takashi Akazawa, Hideaki Tahara, Hideaki Tahara   +5 more
doaj   +2 more sources

Relaxin-2 in Cardiometabolic Diseases: Mechanisms of Action and Future Perspectives [PDF]

Frontiers in Physiology, 2017
Despite the great effort of the medical community during the last decades, cardiovascular diseases remain the leading cause of death worldwide, increasing their prevalence every year mainly due to our new way of life.
Sandra Feijóo-Bandín, Sandra Feijóo-Bandín, Alana Aragón-Herrera, Diego Rodríguez-Penas, Manuel Portolés, Manuel Portolés, Esther Roselló-Lletí, Esther Roselló-Lletí, Miguel Rivera, Miguel Rivera, José R. González-Juanatey, José R. González-Juanatey, Francisca Lago, Francisca Lago   +13 more
doaj   +2 more sources

Relaxin‐2 Ameliorates Spinal Cord Injury by Inhibiting Microglia Activation [PDF]

Kaohsiung Journal of Medical Sciences
This study aims to assess the therapeutic effectiveness of Relaxin‐2 (RLN‐2) in promoting functional recovery and neuroprotection following spinal cord injury (SCI) in mice. Furthermore, continuous subcutaneous infusion of Serelaxin (0.5 mg/kg/day; human
Ji‐Huan Wang, Hong‐Biao Sheng, Jun‐Kun Li   +2 more
doaj   +2 more sources