Results 11 to 20 of about 24,582,015 (196)
A novel role for relaxin-2 in the pathogenesis of primary varicosis. [PDF]
PLoS ONE, 2012 BACKGROUND: Varicose veins affect up to 40% of men and up to 51% of women. The pathophysiology of primary varicosis is poorly understood. Theories ranging from incompetence of the venous valves to structural changes in the vein wall have been proposed ...
Julia Adams +6 more
doaj +7 more sources
Relaxin-2 as a Potential Biomarker in Cardiovascular Diseases. [PDF]
J Pers Med, 2022 The pleiotropic hormone relaxin-2 plays a pivotal role in the physiology and pathology of the cardiovascular system. Relaxin-2 exerts relevant regulatory functions in cardiovascular tissues through the specific receptor relaxin family peptide receptor 1 (RXFP1) in the regulation of cardiac metabolism; the induction of vasodilatation; the reversion of ...
Aragón-Herrera A +9 more
europepmc +4 more sources
Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2011 Review on RLN2 (relaxin 2), with data on DNA, on the protein encoded, and where the gene is implicated.
Willcox, JM, Summerlee, AJS
openaire +4 more sources
Cardiovascular effects of relaxin-2: therapeutic potential and future perspectives. [PDF]
Clin Res Cardiol, 2023 AbstractThe hormone relaxin-2 has emerged as a promising player in regulating the physiology of the cardiovascular system. Through binding to the relaxin family peptide receptor 1 (RXFP1), this hormone elicits multiple physiological responses including vasodilation induction, reduction of inflammation and oxidative stress, and angiogenesis stimulation.
Almeida-Pinto N +3 more
europepmc +5 more sources
Relaxin-2 Expression in Oral Squamous Cell Carcinoma
The International Journal of Biological Markers, 2016 Background When advanced, oral squamous cell carcinoma (OSCC) may involve adjacent non-epithelial structures, and the prognosis is worse for bone invasion. Human relaxin-2 is a peptide hormone that has recently been associated with cancer.
Gino Marioni MD +14 more
doaj +3 more sources
Human relaxin-2: historical perspectives and role in cancer biology [PDF]
Amino Acids, 2012 One of the most recognised and studied family of peptide hormones is the insulin superfamily. Within this family is the relaxin subfamily which comprises seven members: relaxin-1, -2 and -3 and insulin-like peptides 3, 4, 5 and 6. Besides exhibiting sequence similarities, each member exists as an active A-B heterodimer linked by three disulfide bonds ...
Nair, VB +4 more
openaire +5 more sources
BMC Urology, 2020 Background Relaxin is an endogenous protein that has been shown to have antifibrotic properties in various organ systems. There has been no characterization of relaxin’s role in the human bladder.
Edward C. Diaz +7 more
doaj +2 more sources
Relaxin protects astrocytes from hypoxia in vitro.
PLoS ONE, 2014 The peptide relaxin has recently been shown to protect brain tissues from the detrimental effects of ischemia. To date, the mechanisms for this remain unclear. In order to investigate the neuroprotective mechanisms by which relaxin may protect the brain,
Jordan M Willcox, Alastair J S Summerlee
doaj +2 more sources
The neuroprotective effects of relaxin-2 and relaxin-3 [PDF]
, 2013 This thesis concerns the investigation of the neuroprotective effects of the peptides relaxin-2 and relaxin-3. Previous studies have shown that intracerebral relaxin-2 reduces brain lesion size in an in vivo model of stroke, thereby providing evidence of a neuroprotective action of relaxin-2. This thesis set out to extend this work to determine whether
Willcox, Jordan Mark
core +3 more sources
Global CardiologyOn November 25, 2024, Eli Lilly and Company informed the public about the decision to terminate their phase-2 study, J3E-MC-EZDB with the relaxin-2 analogue, LY3540378, after data analysis of 40% of participants had indicated futility without immediate ...
Thomas Bernd Dschietzig, Guy Salama
doaj +2 more sources