Results 31 to 40 of about 24,582,015 (196)

THE ROLE OF RELAXIN HORMONE IN INTERNAL DERANGEMENT OF TEMPROMANDIBULAR JOINT [PDF]

Zagazig University Medical Journal, 2013
To assess the level of relaxin -2 hormone in the serum and synovial fluid in female patient who have anterior disc displacement and detect the effect the wash and lavage on it’s level .Forty patients were included with age ranged between 20-40 age, old ...
Ahmed Shahin, Eman EL Sharrawy, Alaa El-Din Abd El Hamid, Tamer Hamed   +3 more
doaj   +1 more source

Relaxin-2 is a novel biomarker for differentiated thyroid carcinoma in humans. [PDF]

Biochem Pharmacol
Relaxin's role in differentiated thyroid cancer (DTC) has been suggested but its characterization in a large clinical sample remains limited. We performed immunohistochemistry for relaxin-2 (RLN2), CD68 (total macrophages), CD163 (M2 macrophages) on tissue microarrays from 181 subjects with non-distant metastatic DTC, and 185 subjects with benign ...
Kotwal A, Simpson R, Whiteman N, Swanson B, Yuil-Valdes A, Fitch M, Nguyen J, Elhag S, Shats O, Goldner W, Bennett R.   +10 more
europepmc   +3 more sources

Greater presence of receptors for relaxin in the ligamentum teres of female infants who undergo open reduction for developmental dysplasia of the hip

Journal of Orthopaedic Surgery and Research, 2021
Background While many factors involved in the etiology of developmental dysplasia of the hip (DDH), one of which is the hormone relaxin. Relaxin concentrations in patients with DDH may lead to pathodynamic changes during hip development by altering the ...
Semih Ayanoğlu, Haluk Çabuk, Fatmagül Kuşku Çabuk, Kubilay Beng, Timur Yildirim, Süheyla Uyar Bozkurt   +5 more
doaj   +1 more source

Silencing relaxin-3 in nucleus incertus of adult rodents: a viral vector-based approach to investigate neuropeptide function. [PDF]

PLoS ONE, 2012
Relaxin-3, the most recently identified member of the relaxin peptide family, is produced by GABAergic projection neurons in the nucleus incertus (NI), in the pontine periventricular gray.
Gabrielle E Callander, Sherie Ma, Despina E Ganella, Verena C Wimmer, Andrew L Gundlach, Walter G Thomas, Ross A D Bathgate   +6 more
doaj   +1 more source

Relaxin stimulates leukocyte adhesion and migration through a relaxin receptor LGR7-dependent mechanism [PDF]

, 2006
Leukocytes are critical effectors of inflammation and tumor biology. Chemokine-like factors produced by such inflammatory sites are key mediators of tumor growth that activate leukocytic recruitment and tumor infiltration and suppress immune surveillance.
Alice L. Mui, Michael E. Cox, Mui, Alice, Colleen C. Nelson, Kevin A. Figueiredo, Cox, Michael, Figueiredo, Kevin, Nelson, Colleen   +7 more
core   +1 more source

RXFP1 Receptor Activation by Relaxin-2 Induces Vascular Relaxation in Mice via a Gαi2-Protein/PI3Kß/γ/Nitric Oxide-Coupled Pathway

Frontiers in Physiology, 2018
Background: Relaxins are small peptide hormones, which are novel candidate molecules that play important roles in cardiometablic syndrome. Relaxins are structurally related to the insulin hormone superfamily, which provide vasodilatory effects by ...
Xiaoming Lian, Sandra Beer-Hammer, Gabriele M. König, Evi Kostenis, Bernd Nürnberg, Maik Gollasch, Maik Gollasch   +6 more
doaj   +1 more source

Relaxin signals through a RXFP1-pERK-nNOS-NO-cGMP-dependent pathway to up-regulate matrix metalloproteinases: the additional involvement of iNOS. [PDF]

PLoS ONE, 2012
The hormone, relaxin, inhibits aberrant myofibroblast differentiation and collagen deposition by disrupting the TGF-β1/Smad2 axis, via its cognate receptor, Relaxin Family Peptide Receptor 1 (RXFP1), extracellular signal-regulated kinase (ERK)1/2 ...
Bryna Suet Man Chow, Elaine Guo Yan Chew, Chongxin Zhao, Ross A D Bathgate, Tim D Hewitson, Chrishan S Samuel   +5 more
doaj   +1 more source

Chronic treatment with serelaxin mitigates adverse remodeling in a murine model of ischemic heart failure and modulates bioactive sphingolipid signaling

Scientific Reports, 2022
Relaxin is a pleiotropic hormone demonstrated to confer cardioprotection in animal models of myocardial infarction and ischemic heart failure by modulating inflammation, fibrosis and arrhythmogenesis.
Teja Devarakonda, Juan Valle Raleigh, Adolfo G. Mauro, Johana M. Lambert, Lauren Ashley Cowart, Fadi N. Salloum   +5 more
doaj   +1 more source

In vitro effects of relaxin on gene expression in porcine cumulus-oocyte complexes and developing embryos

Reproductive Biology and Endocrinology, 2011
Background Relaxin hormone peptide is found in porcine follicular and utero-tubal fluids, but its possible actions during early embryo development are still undetermined.
Willard Scott T, Greene Jonathan M, Feugang Jean M, Ryan Peter L   +3 more
doaj   +1 more source

Relaxin protects rat lungs from ischemia-reperfusion injury via inducible NO synthase: role of ERK-1/2, PI3K, and forkhead transcription factor FKHRL1.

PLoS ONE, 2013
IntroductionEarly allograft dysfunction following lung transplantation is mainly an ischemia/reperfusion (IR) injury. We showed that relaxin-2 (relaxin) exerts a protective effect in lung IR, attributable to decreases in endothelin-1 (ET-1) production ...
Konstantin Alexiou, Manuel Wilbring, Klaus Matschke, Thomas Dschietzig   +3 more
doaj   +1 more source