Results 41 to 50 of about 24,582,015 (196)
Cellular Physiology and Biochemistry, 2017 Background/Aims: Apoptosis, fibrosis and NLRP3 inflammasome activation are involved in the development of diabetic cardiomyopathy (DCM). Human recombinant relaxin-3 (H3 relaxin) is a novel bioactive peptide that inhibits cardiac injury; however, whether ...
Xiaohui Zhang +9 more
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A vasoactive role for endogenous relaxin in mesenteric arteries of male mice. [PDF]
PLoS ONE, 2014 The peptide hormone relaxin has striking effects on the vascular system. Specifically, endogenous relaxin treatment reduces myogenic reactivity through nitric oxide (NO)-mediated vasorelaxation and increases arterial compliance in small resistance ...
Chen Huei Leo +4 more
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Changes in Knee Laxity and Relaxin Receptor Isoforms Expression (RXFP1/RXFP2) in the Knee throughout Estrous Cycle Phases in Rodents. [PDF]
PLoS ONE, 2016 The changes in knee laxity and relaxin receptor expression at different phases of rodent estrous cycle are not known. Here, changes in the parameter were investigated in rats at different phases of the estrous cycle. Estrous cycle phases of intact female
Firouzeh Dehghan +6 more
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Relaxin Inhibits Ventricular Arrhythmia and Asystole in Rats With Pulmonary Arterial Hypertension
Frontiers in Cardiovascular Medicine, 2021 Pulmonary arterial hypertension (PAH) leads to right ventricular cardiomyopathy and cardiac dysfunctions where in the clinical setting, cardiac arrest is the likely cause of death, in ~70% of PAH patients.
Brian Martin +31 more
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In vitro pharmacological characterization of RXFP3 allosterism: an example of probe dependency. [PDF]
PLoS ONE, 2012 Recent findings suggest that the relaxin-3 neural network may represent a new ascending arousal pathway able to modulate a range of neural circuits including those affecting circadian rhythm and sleep/wake states, spatial and emotional memory, motivation
Lily Alvarez-Jaimes +7 more
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Frontiers in Pharmacology, 2022 The peptide hormone relaxin (RLX), also available as clinical-grade recombinant protein (serelaxin), holds great promise as a cardiovascular and anti-fibrotic agent but is limited by the pharmacokinetic issues common to all peptide drugs.
Annunziata D'Ercole +12 more
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Evolution of the relaxin-like peptide family
BMC Evolutionary Biology, 2005 Background The relaxin-like peptide family belongs in the insulin superfamily and consists of 7 peptides of high structural but low sequence similarity; relaxin-1, 2 and 3, and the insulin-like (INSL) peptides, INSL3, INSL4, INSL5 and INSL6.
Tregear Geoffrey W +3 more
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The role of breast milk beta-endorphin and relaxin-2 on infant colic
Pediatric Research, 2023 The relationship between infant colic and breast milk beta-endorphin (BE) and relaxin-2 (RLX-2) has not been studied before.Thirty colic infants and their mothers constituted the study group, and the same sex, similar age and healthy infants and their mothers formed the control group.
Ozturk, Nurinnisa +3 more
openaire +3 more sources
Advanced Science, EarlyView.Integrative multi‐omics analysis delineates a mitochondrial–immune axis governing neoadjuvant chemotherapy response in high‐grade serous ovarian cancer. Immune‐active tumors exhibit enhanced B‐cell infiltration and favorable sensitivity, whereas metabolically rewired tumors display oxidative phosphorylation dependency and resistance.
Wei Jiang +11 more
wiley +1 more source
, 2007 The small peptide hormone relaxin is a member of a rapidly evolving family of hormones and growth factors, whose mode of action appears to be particularly adapted to purely mammalian physiology.
Heng, K., Anand Ivell, R., Ivell, R.
core +1 more source