Results 21 to 30 of about 24,582,015 (196)

Solution Structure, Aggregation Behavior, and Flexibility of Human Relaxin-2

ACS Chemical Biology, 2015
Relaxin is a member of the relaxin/insulin peptide hormone superfamily and is characterized by a two-chain structure constrained by three disulfide bonds. Relaxin is a pleiotropic hormone and involved in a number of physiological and pathogenic processes, including collagen and cardiovascular regulation and tissue remodelling during pregnancy and ...
Haugaard-Kedstrom, Linda, Hossain, Mohammed Akhter, Daly, Norelle L., Bathgate, Ross A. D., Rinderknecht, Ernst, Wade, John D., Craik, David J., Rosengren, Karl Johan   +7 more
openaire   +6 more sources

Cardiovascular Effects of Relaxin-2: Therapeutic Potential and Future Perspectives [PDF]

, 2023
A hormona Relaxina-2 tem vindo a destacar-se como um elemento promissor na regulação da fisiologia do sistema cardiovascular. Ao atuar através do receptor de peptídeo da família da Relaxina 1 (RXFP1), produz diferentes efeitos, desde da indução da vasodilatação, prevenção da fibrose, redução da inflamação e do stress oxidativo, até à estimulação da ...
Nisia Maria Lima de Almeida Pinto
openaire   +3 more sources

Distinct activation modes of the Relaxin Family Peptide Receptor 2 in response to insulin-like peptide 3 and relaxin [PDF]

Scientific Reports, 2017
Relaxin family peptide receptor 2 (RXFP2) is a GPCR known for its role in reproductive function. It is structurally related to the human relaxin receptor RXFP1 and can be activated by human gene-2 (H2) relaxin as well as its cognate ligand insulin-like ...
Shoni Bruell, Ashish Sethi, Nicholas Smith, Daniel J. Scott, Mohammed Akhter Hossain, Qing-Ping Wu, Zhan-Yun Guo, Emma J. Petrie, Paul R. Gooley, Ross A. D. Bathgate   +9 more
doaj   +2 more sources

Mediation Effect of Relaxin in Cerebrospinal Fluid on the Association Between Smoking and Sleep [PDF]

Nature and Science of Sleep
Zeping Xu,1,* Mingwei Ma,2,* Yanlong Liu,2,* Jiayi Tang,3 Xingguang Luo,4 Yu-Hsin Chen,2 Kexin Wang,2 Xiyi Chen,2 Yimin Kang,5 Ke Zheng,6 Weiming Hu,7 Li Chen,2 Fan Wang,8 Yuyu Wu9,10 1Department of Pharmacy, Ningbo Medical Center Li Huili ...
Xu Z, Ma M, Liu Y, Tang J, Luo X, Chen YH, Wang K, Chen X, Kang Y, Zheng K, Hu W, Chen L, Wang F, Wu Y   +13 more
doaj   +1 more source

Further Developments towards a Minimal Potent Derivative of Human Relaxin-2. [PDF]

Int J Mol Sci, 2023
Human relaxin-2 (H2 relaxin) is a peptide hormone with potent vasodilatory and anti-fibrotic effects, which is of interest for the treatment of heart failure and fibrosis. H2 relaxin binds to the Relaxin Family Peptide Receptor 1 (RXFP1). Native H2 relaxin is a two-chain, three-disulfide-bond-containing peptide, which is unstable in human serum and ...
Handley TNG, Praveen P, Tailhades J, Wu H, Bathgate RAD, Hossain MA.   +5 more
europepmc   +4 more sources

Intraarticular injection of relaxin-2 alleviates shoulder arthrofibrosis. [PDF]

Proc Natl Acad Sci U S A, 2019
Arthrofibrosis is a prevalent condition affecting greater than 5% of the general population and leads to a painful decrease in joint range of motion (ROM) and loss of independence due to pathologic accumulation of periarticular scar tissue. Current treatment options are limited in effectiveness and do not address the underlying cause of the condition ...
Blessing WA, Okajima SM, Cubria MB, Villa-Camacho JC, Perez-Viloria M, Williamson PM, Sabogal AN, Suarez S, Ang LH, White S, Flynn E, Rodriguez EK, Grinstaff MW, Nazarian A.   +13 more
europepmc   +4 more sources

Minimally invasive, sustained-release relaxin-2 microparticles reverse arthrofibrosis. [PDF]

Sci Transl Med, 2022
Substantial advances in biotherapeutics are distinctly lacking for musculoskeletal diseases. Musculoskeletal diseases are biomechanically complex and localized, highlighting the need for novel therapies capable of addressing these issues. All frontline treatment options for arthrofibrosis, a debilitating musculoskeletal disease, fail to treat the ...
Kirsch JR, Williamson AK, Yeritsyan D, Blessing WA, Momenzadeh K, Leach TR, Williamson PM, Korunes-Miller JT, DeAngelis JP, Zurakowski D, Nazarian RM, Rodriguez EK, Nazarian A, Grinstaff MW.   +13 more
europepmc   +3 more sources

The Minimal Active Structure of Human Relaxin-2 [PDF]

Journal of Biological Chemistry, 2011
H2 relaxin is a peptide hormone associated with a number of therapeutically relevant physiological effects, including regulation of collagen metabolism and multiple vascular control pathways. It is currently in phase III clinical trials for the treatment of acute heart failure due to its ability to induce vasodilation and influence renal function.
Hossain, MA, Rosengren, KJ, Samuel, CS, Shabanpoor, F, Chan, LJ, Bathgate, RAD, Wade, JD   +6 more
openaire   +5 more sources

Role of relaxin-2 in human primary osteosarcoma [PDF]

Cancer Cell International, 2013
The aim of this study was to clarify the clinicopathological outcome of serum relaxin-2 and tissues relaxin-2 expression levels in human primary osteosarcoma (OS), and to explore the roles of relaxin-2 inhibition and determine its possibility as a therapeutic target in human osteosarcoma.Real-time quantitative RT-PCR assay was performed to detect the ...
Ma, Jinfeng, Niu, Min, Yang, Wenjiu, Zang, Lina, Xi, Yongming   +4 more
openaire   +2 more sources

Do Relaxin Levels Impact Hip Injury Incidence in Women? A Scoping Review

Frontiers in Endocrinology, 2022
PurposeThe aim of this review is to assess the current evidence regarding the impact of relaxin on incidence of soft tissue hip injuries in women.MethodsA trained research librarian assisted with searches of PubMed, Embase, CINAHL, and SPORTDiscus, with ...
Emily A. Parker, Alex M. Meyer, Jessica E. Goetz, Jessica E. Goetz, Michael C. Willey, Robert W. Westermann   +5 more
doaj   +1 more source