PLoS Biology, 2018 Descent of testes from a position near the kidneys into the lower abdomen or into the scrotum is an important developmental process that occurs in all placental mammals, with the exception of five afrotherian lineages.
Virag Sharma +4 more
doaj +2 more sources
Long divergent haplotypes introgressed from wild sheep are associated with distinct morphological and adaptive characteristics in domestic sheep. [PDF]
PLoS Genetics, 2023 The worldwide sheep population comprises more than 1000 breeds. Together, these exhibit a considerable morphological diversity, which has not been extensively investigated at the molecular level.
Hong Cheng +18 more
doaj +2 more sources
A variant in intron 11 of RXFP2 gene is associated with the polled phenotype in North Aegean sheep populations [PDF]
, 2020 In the present GWAS, first, we detected additive and dominant genetic variants associated with the horned/polled phenotype in a sheep population (n=256) dispersed on three Greek islands (Lemnos, Lesvos and Agios Efstratios) and second we identified the ...
Hadjigeorgiou, Ioannis +3 more
core +4 more sources
Type 1 diabetes impairs the activity of rat testicular somatic and germ cells through NRF2/NLRP3 pathway-mediated oxidative stress [PDF]
Frontiers in EndocrinologyBackgroundIt is well known that metabolic disorders, including type 1 diabetes (T1D), are often associated with reduced male fertility, mainly increasing oxidative stress and impairing the hypothalamus–pituitary–testis (HPT) axis, with consequently ...
Massimo Venditti +6 more
doaj +2 more sources
Sheep with partial RXFP2 knockout exhibit normal horn phenotype but unilateral cryptorchidism
Journal of Integrative Agriculture, 2023 Yawei Gao +15 more
doaj +3 more sources
Novel Insights into the Bovine Polled Phenotype and Horn Ontogenesis in Bovidae [PDF]
, 2013 Despite massive research efforts, the molecular etiology of bovine polledness and the developmental pathways involved in horn ontogenesis are still poorly understood.
Allais-Bonnet, Aurélie +48 more
core +18 more sources
Profiling insulin like factor 3 (INSL3) signaling in human osteoblasts. [PDF]
PLoS ONE, 2011 BACKGROUND: Young men with mutations in the gene for the INSL3 receptor (Relaxin family peptide 2, RXFP2) are at risk of reduced bone mass and osteoporosis.
Alberto Ferlin +4 more
doaj +1 more source
Total chemical synthesis of a heterodimeric interchain Bis-Lactam-linked peptide: application to an analogue of human insulin-like peptide 3 [PDF]
, 2013 Nonreducible cystine isosteres represent important peptide design elements in that they can maintain a near-native tertiary conformation of the peptide while simultaneously extending the in vitro and in vivo half-life of the biomolecule.
Gardiner, J. +6 more
core +6 more sources
Cryptorchidism in the orl rat is associated with muscle patterning defects in the fetal gubernaculum and altered hormonal signaling [PDF]
, 2014 Cryptorchidism, or undescended testis, is a common male genital anomaly of unclear etiology. Hormonal stimulation of the developing fetal gubernaculum by testicular androgens and insulin-like 3 (INSL3) is required for testicular descent.
Abigail Mateson +9 more
core +1 more source
The genomes and history of domestic animals [PDF]
, 2016 This paper reviews how mammalian genomes are utilized in modern genetics for the detection of genes and polymorphisms (mutations) within domesticated animal (mostly livestock) genomes that are related to traits of economic importance to humans.
Larkin, D M, Yudin, N S
core +2 more sources