Results 41 to 50 of about 1,025 (152)
Physiology and evolution of the INSL3/RXFP2 hormone/receptor system in higher vertebrates
General and Comparative Endocrinology, 2020 Although the insulin-like peptide hormone INSL3 and its cognate receptor RXFP2 (relaxin-family peptide receptor 2) have existed throughout chordate evolution, their physiological diversification appears to be linked closely with mammalian emergence and radiation. In contrast, they have been lost in birds and reptiles.
Richard, Ivell +3 more
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Examination of relaxin and its receptors expression in pig gametes and embryos
Reproductive Biology and Endocrinology, 2011 Background Relaxin is a small peptide also known as pregnancy hormone in many mammals. It is synthesized by both male and female tissues, and its secretions are found in various body fluids such as plasma serum, ovarian follicular fluid, utero-oviduct ...
Bathgate Ross A +4 more
doaj +1 more source
The evolving role of whole-exome sequencing in the management of disorders of sex development
Endocrine Connections, 2021 Objective: Disorders of sex development (DSD) are defined as congenital co nditions in which the development of chromosomal, gonadal and anatomical sex is atypical.
Yardena Tenenbaum-Rakover +11 more
doaj +1 more source
The Different Ligand-Binding Modes of Relaxin Family Peptide Receptors RXFP1 and RXFP2 [PDF]
Molecular Endocrinology, 2012 Relaxin and insulin-like peptide 3 (INSL3) are peptide hormones with a number of important physiological roles in reproduction, regulation of extracellular matrix turnover, and cardiovascular function. Relaxin and INSL3 mediate their actions through the closely related G-protein coupled receptors, relaxin family peptide receptors 1 and 2 (RXFP1 and ...
Scott, Daniel J. +2 more
openaire +5 more sources
Expression and Role of INSL3 in the Fetal Testis
Frontiers in Endocrinology, 2022 Insulin-like peptide 3 (INSL3) is a small peptide hormone of the insulin-relaxin family which is produced and secreted by the fetal Leydig cells in the testes only. It appears to be undetectable in female fetuses.
Richard Ivell +3 more
doaj +1 more source
PLoS Biology, 2018 Descent of testes from a position near the kidneys into the lower abdomen or into the scrotum is an important developmental process that occurs in all placental mammals, with the exception of five afrotherian lineages.
Virag Sharma +4 more
doaj +1 more source
Cellular & Molecular Biology Letters, 2023 Background Testicular hypoplasia can affect the sexual and reproductive ability in adulthood, and even increase the risk of cancer. Abnormal development of the gubernaculum is one of the important factors of testicular hypoplasia.
Shouxing Duan +12 more
doaj +1 more source
BMC Urology, 2020 Background Relaxin is an endogenous protein that has been shown to have antifibrotic properties in various organ systems. There has been no characterization of relaxin’s role in the human bladder.
Edward C. Diaz +7 more
doaj +1 more source
Bone Health and Aging in Klinefelter Syndrome
Andrology, EarlyView.ABSTRACT Klinefelter syndrome (KS) is typically diagnosed in young adults, but advances in prenatal testing have led to its recognition at a much earlier age. Conversely, diagnosis in late adulthood remains uncommon, but still occurs. Independently from the age at diagnosis, KS individuals now receive more accurate and tailored care management than in ...
Filippo Vignali +4 more
wiley +1 more source
The structural determinants of insulin-like peptide 3 activity
Frontiers in Endocrinology, 2012 INSL3 is a hormone and/or paracrine factor which is a member of the relaxin peptide family. It has key roles as a fertility regulator in both males and females. The receptor for INSL3 is the leucine rich repeat (LRR) containing G-protein coupled receptor
Ross AD Bathgate +5 more
doaj +1 more source