Results 61 to 70 of about 1,025 (152)

Genetic Risk Factors in Normal Pressure Hydrocephalus: What We Know and What Is Next

Movement Disorders, Volume 40, Issue 7, Page 1233-1247, July 2025.
Abstract Knowledge of the genetic factors in normal pressure hydrocephalus (NPH) is rapidly evolving, with significant advances in recent years. We conducted a systematic review examining genetic contributions to NPH risk. Ovid Embase, Ovid Medline, Web of Science, and Cochrane Central were searched from inception through October 14, 2024, for human ...
Camila C. Piccinin, Saar Anis, Jeryl Ritzi T. Yu, Philippe A. Salles, Henry Mauricio Chaparro‐Solano, Avery Kundrick, Shelley Ivary, James Y. Liao, Sean J. Nagel, Ignacio F. Mata   +9 more
wiley   +1 more source

Genetic and histopathological analysis of transverse testicular ectopia without persistent Müllerian duct syndrome: two case reports

Journal of Medical Case Reports, 2020
Background Transverse testicular ectopia (TTE) is a rare anomaly in which both testes descend through a single inguinal canal into the same hemiscrotum.
Takashi Nagai, Kentaro Mizuno, Masayuki Usami, Hidenori Nishio, Taiki Kato, Akihiro Nakane, Daisuke Matsumoto, Satoshi Kurokawa, Hideyuki Kamisawa, Tetsuji Maruyama, Takahiro Yasui, Yutaro Hayashi   +11 more
doaj   +1 more source

Genomic technologies and the diagnosis of 46, XY differences of sex development

Andrology, Volume 13, Issue 5, Page 1025-1043, July 2025.
Abstract Differences/disorders of sex development can be caused by disruptions to the molecular and cellular mechanisms that control development and sex determination of the reproductive organs with 1:100 live births affected. Multiple genes are associated with 46, XY differences/disorders of sex development that can cause varying clinical phenotypes ...
Firman Idris, Andrew H. Sinclair, Katie L. Ayers   +2 more
wiley   +1 more source

Long divergent haplotypes introgressed from wild sheep are associated with distinct morphological and adaptive characteristics in domestic sheep.

PLoS Genetics, 2023
The worldwide sheep population comprises more than 1000 breeds. Together, these exhibit a considerable morphological diversity, which has not been extensively investigated at the molecular level.
Hong Cheng, Zhuangbiao Zhang, Jiayue Wen, Johannes A Lenstra, Rasmus Heller, Yudong Cai, Yingwei Guo, Ming Li, Ran Li, Wenrong Li, Sangang He, Jintao Wang, Junjie Shao, Yuxuan Song, Lei Zhang, Masum Billah, Xihong Wang, Mingjun Liu, Yu Jiang   +18 more
doaj   +1 more source

History and genetic diversity of African sheep: Contrasting phenotypic and genomic diversity

Animal Genetics, Volume 56, Issue 1, February 2025.
Abstract Domesticated sheep have adapted to contrasting and extreme environments and continue to play important roles in local community‐based economies throughout Africa. Here we review the Neolithic migrations of thin‐tailed sheep and the later introductions of fat‐tailed sheep into eastern Africa.
Anne Da Silva, Abulgasim Ahbara, Imen Baazaoui, Slim Ben Jemaa, Yinhong Cao, Elena Ciani, Edgar Farai Dzomba, Linda Evans, Elisha Gootwine, Olivier Hanotte, Laura Harris, Meng‐Hua Li, Salvatore Mastrangelo, Ayao Missohou, Annelin Molotsi, Farai C. Muchadeyi, Joram M. Mwacharo, Gaëlle Tallet, Pascal Vernus, Stephen J. G. Hall, Johannes A. Lenstra   +20 more
wiley   +1 more source

Transcriptional Crosstalk between INSL3 and Androgen Receptor in Foetal Leydig Cells: Molecular Insights into TDS

Fertility & Reproduction
Testicular Dysgenesis Syndrome (TDS) encompasses a spectrum of male reproductive disorders that originate during fetal development. Among the critical players in testicular morphogenesis, fetal Leydig cells perform essential functions through the ...
Ajitha E. Veluthakunju, Sravanthi Puvvada, Sundaresan Saravana Kumar, Georgy Joy Eralil, Anupama Dhanapalan Chettiyar, Jayasudha Edatholath, Jineesh Valluvanga Chalil, Arun William, Aswathy Sundaresh, Dinesh Roy Divakaran   +9 more
doaj   +1 more source

The role of G protein‐coupled receptors and their ligands in animal domestication

Animal Genetics, Volume 55, Issue 6, Page 893-906, December 2024.
Abstract The domestication of plants and animals has resulted in one of the most significant cultural and socio‐economical transitions in human history. Domestication of animals, including human‐supervised reproduction, largely uncoupled particular animal species from their natural, evolutionary history driven by environmental and ecological factors ...
Gunnar Kleinau, Bice Chini, Leif Andersson, Patrick Scheerer   +3 more
wiley   +1 more source

Contribution of T‐type calcium channel isoforms to cold and mechanical sensitivity in naïve and oxaliplatin‐treated mice of both sexes

British Journal of Pharmacology, Volume 181, Issue 24, Page 5062-5078, December 2024.
Background and Purpose The chemotherapy agent oxaliplatin can give rise to oxaliplatin‐induced peripheral neuropathy (OIPN). Here, we investigated whether T‐type calcium channels (Cav3) contribute to OIPN. Experimental Approach We chronically treated mice with oxaliplatin and assessed pain responses and changes in expression of Cav3.2 calcium channels.
Flavia T. T. Antunes, Maria A. Gandini, Vinicius M. Gadotti, Nara Lins Meira Quintão, José Roberto Santin, Ivana A. Souza, Laurence S. David, Terrance P. Snutch, Michael Hildebrand, Gerald W. Zamponi   +9 more
wiley   +1 more source

Relaxin Receptor RXFP1 and RXFP2 Expression in Ligament, Tendon, and Shoulder Joint Capsule of Rats

Journal of Korean Medical Science, 2016
Numerous musculoskeletal disorders are caused by thickened ligament, tendon stiffness, or fibrosis of joint capsule. Relaxin, a peptide hormone, can exert collagenolytic effect on ligamentous and fibrotic tissues. We hypothesized that local injection of relaxin could be used to treat entrapment neuropathy and adhesive capsulitis.
Jae Hyung Kim, Sang Kwang Lee, Seong Kyu Lee, Joo Heon Kim, Michael Fredericson   +4 more
openaire   +2 more sources

Expression and function of G-protein-coupled receptorsin the male reproductive tract

Anais da Academia Brasileira de Ciências, 2009
This review focuses on the expression and function of muscarinic acetylcholine receptors (mAChRs), α1-adrenoceptors and relaxin receptors in the male reproductive tract.
Maria Christina W. Avellar, Maria Fatima M. Lázari, Catarina S. Porto   +2 more
doaj   +1 more source