Results 71 to 80 of about 1,025 (152)

Primary Aldosteronism Influences Cardiac Structure, Function, and Disease Risk: Evidence From Mendelian Randomization Analysis

The Journal of Clinical Hypertension, Volume 26, Issue 11, Page 1301-1309, November 2024.
ABSTRACT Although observational studies have linked primary aldosteronism (PA) with cardiovascular diseases (CVDs), the causality remains uncertain. In this study, we aimed to investigate whether PA is causally associated with CVD risk and cardiac magnetic resonance (CMR) parameters using the Mendelian randomization (MR) method.
Rui Shen, Chengliang Pan, Jian Yu, Chen Dong, Zhiyang Li, Jiangmei Zhang, Qian Dong, Kunwu Yu, Qiutang Zeng   +8 more
wiley   +1 more source

Sheep with partial RXFP2 knockout exhibit normal horn phenotype but unilateral cryptorchidism

Journal of Integrative Agriculture
Yawei Gao, Siyuan Xi, Bei Cai, Tingjie Wu, Qian Wang, Peter Kalds, Shuhong Huang, Yuhui Wang, Saizheng Han, Menghao Pan, Chong Yang, Qifang Kou, Baohua Ma, Xiaolong Wang, Shiwei Zhou, Yulin Chen   +15 more
doaj   +2 more sources

Multiple genomic solutions for local adaptation in two closely related species (sheep and goats) facing the same climatic constraints

Molecular Ecology, Volume 33, Issue 20, October 2024.
Abstract The question of how local adaptation takes place remains a fundamental question in evolutionary biology. The variation of allele frequencies in genes under selection over environmental gradients remains mainly theoretical and its empirical assessment would help understanding how adaptation happens over environmental clines.
Badr Benjelloun, Kevin Leempoel, Frédéric Boyer, Sylvie Stucki, Ian Streeter, Pablo Orozco‐terWengel, Florian J. Alberto, Bertrand Servin, Filippo Biscarini, Adriana Alberti, Stefan Engelen, Alessandra Stella, Licia Colli, Eric Coissac, Michael W. Bruford, Paolo Ajmone‐Marsan, Riccardo Negrini, Laura Clarke, Paul Flicek, Abdelkader Chikhi, Stéphane Joost, Pierre Taberlet, François Pompanon   +22 more
wiley   +1 more source

In vitro effects of relaxin on gene expression in porcine cumulus-oocyte complexes and developing embryos

Reproductive Biology and Endocrinology, 2011
Background Relaxin hormone peptide is found in porcine follicular and utero-tubal fluids, but its possible actions during early embryo development are still undetermined.
Willard Scott T, Greene Jonathan M, Feugang Jean M, Ryan Peter L   +3 more
doaj   +1 more source

Insulin-like factor 3 (INSL3) and the HPG axis in the male

Frontiers in Endocrinology, 2014
The HPG (hypothalamo-pituitary-gonadal) axis comprises pulsatile GnRH from the hypothalamus impacting on the anterior pituitary to induce expression and release of both LH and FSH into the circulation.
Richard eIvell, Richard eIvell, Kee eHeng, Ravinder eAnand-Ivell   +3 more
doaj   +1 more source

Genomic prediction of the polled and horned phenotypes in Merino sheep

Genetics Selection Evolution, 2018
Background In horned sheep breeds, breeding for polledness has been of interest for decades. The objective of this study was to improve prediction of the horned and polled phenotypes using horn scores classified as polled, scurs, knobs or horns.
Naomi Duijvesteijn, Sunduimijid Bolormaa, Hans D. Daetwyler, Julius H. J. van der Werf   +3 more
doaj   +1 more source

Multi-Component Mechanism of H2 Relaxin Binding to RXFP1 through NanoBRET Kinetic Analysis

iScience, 2019
Summary: The peptide hormone H2 relaxin has demonstrated promise as a therapeutic, but mimetic development has been hindered by the poorly understood relaxin receptor RXFP1 activation mechanism.
Bradley L. Hoare, Shoni Bruell, Ashish Sethi, Paul R. Gooley, Michael J. Lew, Mohammed A. Hossain, Asuka Inoue, Daniel J. Scott, Ross A.D. Bathgate   +8 more
doaj   +1 more source

Type 1 diabetes impairs the activity of rat testicular somatic and germ cells through NRF2/NLRP3 pathway-mediated oxidative stress

Frontiers in Endocrinology
BackgroundIt is well known that metabolic disorders, including type 1 diabetes (T1D), are often associated with reduced male fertility, mainly increasing oxidative stress and impairing the hypothalamus–pituitary–testis (HPT) axis, with consequently ...
Massimo Venditti, Maria Zelinda Romano, Serena Boccella, Asma Haddadi, Alessandra Biasi, Sabatino Maione, Sergio Minucci   +6 more
doaj   +1 more source

Advances in deer antler research based on single-cell multi-omics approaches. [PDF]

Front Cell Dev Biol
Ba H, Li C.
europepmc   +1 more source

Cranial Appendages in Ruminants: Diversity, Evolution, Development, and Molecular Basis of Horns, Pronghorns, Antlers, and Ossicones. [PDF]

Biology (Basel)
Piprek RP, Rams-Pociecha I, Mizia PC.
europepmc   +1 more source