Results 1 to 10 of about 4,038 (203)

Expression of insulin-like 3 (INSL3) and differential splicing of its receptor in the ovary of rhesus macaques [PDF]

Reproductive Biology and Endocrinology, 2010
Background Although insulin-like 3 (INSL3) has been identified in the gonad of both sexes in many species, there are only limited reports on the distribution of INSL3 and its receptor, relaxin/insulin-like family peptide receptor 2 (RXFP2), in the ...
Jensen Jeffrey T, Patta Maristela C, Yao Shan, Hanna Carol B, Wu Xuemei   +4 more
doaj   +2 more sources

Serum Concentrations and Gonadal Expression of INSL3 in Eighteen Males With 45,X/46,XY Mosaicism

Frontiers in Endocrinology, 2021
ObjectiveInsulin-like factor 3 (INSL3) is produced in the testes and has been proposed as a circulating biomarker of Leydig cell capacity, but remains undescribed in 45,X/46,XY mosaicism. The aim was to examine serum concentrations and gonadal expression
Marie Lindhardt Ljubicic, Lise Aksglaede, Jakob Albrethsen   +2 more
exaly   +3 more sources

Insulin-like peptide 3 is not a biomarker for pancreatic ductal adenocarcinoma [PDF]

Frontiers in Endocrinology
Pancreatic ductal carcinoma (PDAC) is a rapidly growing cancer with a very poor prognosis. It is, therefore, important to develop novel, specific biomarkers to identify such cancers as early as possible.
Ravinder Anand-Ivell, Xinyuan Yang, Ruediger Braun, Hendrik Ungefroren, Richard Ivell, Richard Ivell   +5 more
doaj   +2 more sources

Effects of INSL3 and WNT2B gene polymorphisms on seasonal reproductive traits of Xinjiang Qira black sheep, Kazakh sheep and Duolang sheep [PDF]

Animal Biotechnology
The purpose of this study was to investigate the polymorphism and genetic correlation of INSL3 and WNT2B genes with seasonal estrus and litter size in three different Xinjiang sheep breeds.
Jingdong Bi, Sulaiman Yiming, Jiaqi Li, Quanfeng Wang, Manjun Zhai, Shaoqi Cao, Mengting Zhu, Hua Yang   +7 more
doaj   +2 more sources

Theca Cell INSL3 and Steroids Together Orchestrate the Growing Bovine Antral Follicle [PDF]

Frontiers in Physiology, 2017
Insulin-like peptide 3 (INSL3) and its specific receptor RXFP2 are both expressed by theca interna cells of the growing antral follicle where they form an essential regulatory element in the production of the steroid precursor androstenedione.
Yanzhenzi Dai, Richard Ivell, Richard Ivell, Richard Ivell, Ravinder Anand-Ivell   +4 more
doaj   +3 more sources

Potential ability of circulating INSL3 level for the prediction of ovarian reserve and IVF success as a novel theca cell–specific biomarker in women with unexplained infertility and diminished ovarian reserve [PDF]

Reproductive Biology and Endocrinology
Background Insulin-like peptide (INSL3), belonging to the insulin-like peptide family, is produced by theca interna cells within antral follicles and the corpora lutea.
Pinar Ozcan, F. Sezer, A. Altun, C. Yildiz, H. T. Timur, E. C. Keles, O. Dural, H. S. Taha, E. Saridogan   +8 more
doaj   +2 more sources

The Male Fetal Biomarker INSL3 Reveals Substantial Hormone Exchange between Fetuses in Early Pig Gestation. [PDF]

PLoS ONE, 2016
The peptide hormone INSL3 is uniquely produced by the fetal testis to promote the transabdominal phase of testicular descent. Because it is fetal sex specific, and is present in only very low amounts in the maternal circulation, INSL3 acts as an ideal ...
Andreas Vernunft, Richard Ivell, Kee Heng, Ravinder Anand-Ivell   +3 more
doaj   +5 more sources

Defining the end of puberty in boys: INSL3 and the acute determinants of adult Leydig-cell functional capacity [PDF]

Frontiers in Endocrinology
IntroductionTesticular Leydig cells are responsible for producing almost all the testosterone required by men throughout the lifespan, with reduced testosterone (hypogonadism) correlating with age-linked morbidity and mortality.
Bilal Tulumcu, Richard Ivell, Waleed Alhujaili, Ravinder Anand-Ivell   +3 more
doaj   +2 more sources

Protective Role of Testicular Hormone INSL3 From Atrophy and Weakness in Skeletal Muscle

Frontiers in Endocrinology, 2018
Androgens are primarily involved in muscle growth, whilst disease-driven muscle wasting is frequently associated with hypogonadism. The Leydig cells of the testes also produce the peptide-hormone Insulin-like peptide 3 (INSL3).
Alberto Ferlin, Luca De Toni, Alexander I Agoulnik   +2 more
exaly   +3 more sources

Evolutionary relaxation and functional change of INSL3 and RXFP2 may underlie natural cryptorchidism in mammals [PDF]

EMBO Reports
Cryptorchidism is a common congenital abnormality that increases infertility and testicular cancer risk in adulthood. However, a few mammals exhibit naturally undescended testes while maintaining normal reproduction.
Yu Zheng, Simin Chai, Cuijuan Zhong, Yixuan Sun, Shixia Xu, Wenhua Ren, Guang Yang   +6 more
doaj   +2 more sources