Results 11 to 20 of about 4,038 (203)

Expression and Role of INSL3 in the Fetal Testis

Frontiers in Endocrinology, 2022
Insulin-like peptide 3 (INSL3) is a small peptide hormone of the insulin-relaxin family which is produced and secreted by the fetal Leydig cells in the testes only. It appears to be undetectable in female fetuses.
Richard Ivell, Linn Salto Mamsen, Claus Yding Andersen, Ravinder Anand-Ivell   +3 more
doaj   +5 more sources

INSL3 as a biomarker of Leydig cell functionality [PDF]

Biology of Reproduction, 2013
Insulin-like factor 3 (INSL3) is a small peptide hormone made and secreted uniquely by mature Leydig cells in the testes of all mammals. Importantly, this expression and secretion appears to be constitutive and therefore reflects the differentiation ...
Anand-Ivell, Ravinder, Ivell, Richard, Wade, John D.   +2 more
core   +4 more sources

Serum INSL3 measured by LC-MS/MS in pubertal girls and in girls with precocious puberty during GnRH agonist treatment [PDF]

Frontiers in Endocrinology
IntroductionThe peptide hormone Insulin-like Factor 3 (INSL3) is a biomarker of testicular Leydig cells in the male but is also expressed by the theca cells of the ovaries. With the advent of sensitive assays INSL3 can be quantified in female circulation,
Jakob Albrethsen, Jakob Albrethsen, Casper P. Hagen, Casper P. Hagen, Anders Juul, Anders Juul, Anders Juul   +6 more
doaj   +2 more sources

Spermatic RXFP2 expression levels and seminal INSL3 concentrations among beef bull ejaculates with different levels of sperm morphological normality [PDF]

The Journal of Reproduction and Development
The objective of this study was to examine the relationship between the insulin-like peptide 3 (INSL3) receptor (RXFP2) expression levels on spermatozoa and INSL3 concentrations in the seminal plasma of fresh semen from beef bulls with different levels ...
Hewage Dilhan Anuradha WIMALARATHNE, Kenta ARASHI, Fumiyuki IWAKI, Mitsuhiro SAKASE, DURITAHALA, Hiroshi HARAYAMA, Noritoshi KAWATE   +6 more
doaj   +2 more sources

Amniotic Fluid INSL3 Measured During the Critical Time Window in Human Pregnancy Relates to Cryptorchidism, Hypospadias, and Phthalate Load: A Large Case–Control Study [PDF]

Frontiers in Physiology, 2018
The period of the first to second trimester transition in human pregnancy represents a sensitive window for fetal organogenesis, particularly in regard to the development of the male reproductive system.
Ravinder Anand-Ivell, Arieh Cohen, Bent Nørgaard-Pedersen, Bo A. G. Jönsson, Jens-Peter Bonde, David M. Hougaard, Christian H. Lindh, Gunnar Toft, Morten S. Lindhard, Richard Ivell, Richard Ivell   +10 more
doaj   +6 more sources

INSL3 Expression in Leydig Cells is a Biomarker for Immunocastration in Boars: Transcriptional Evidence. [PDF]

Andrology
ABSTRACT Background Study aimed to obtain insights into physiological responses to immunocastration in pubertal boars by evaluating effects of alternative vaccination protocols and identifying a reliable immunocastration biomarker. Objectives It was hypothesized that the timing of gonadotropin‐releasing hormone (GnRH) suppression by immunocastration ...
Lukač NB, Škrlep M, Poklukar K, Ferjan P, Stefanski V, Fazarinc G, Vrecl M.   +6 more
europepmc   +2 more sources

Endothelial PDGF Signaling Dysregulation Impairs Testicular Interstitial Homeostasis in Diabetes. [PDF]

Adv Sci (Weinh)
Testicular endothelial cells (TECs) function as central signaling hubs that coordinate interstitial homeostasis. Diabetes disrupts TEC‐derived PDGF signaling, silences the JUND‐MCL1 survival program in Leydig cells, and impairs peritubular function, leading to fibrosis and testosterone insufficiency.
Zhang W, Hong K, Tang Y, Cui L, Lu X, Cheng J, Fang Y, Jiang Q, Zhuang Z, Gao S, Jiang H, Liu Q, Guo J, Zhang Z, Wang X.   +14 more
europepmc   +2 more sources

Insulin‐like peptide 3 in domestic animals with normal and abnormal reproductive functions, in comparison to rodents and humans

Reproductive Medicine and Biology, 2022
Background Insulin‐like peptide 3 (INSL3) is a circulating hormone secreted from only testis and ovaries in mammals. Findings on INSL3 have been gathered from subjects with normal and abnormal reproductive statuses, especially rodents and humans. However,
Noritoshi Kawate
doaj   +1 more source

The Leydig cell biomarker INSL3 as a predictor of age-related morbidity: Findings from the EMAS cohort

Frontiers in Endocrinology, 2022
BackgroundInsulin-like peptide 3 (INSL3) is a constitutive hormone secreted in men by the mature Leydig cells of the testes. It is an accurate biomarker for Leydig cell functional capacity, reflecting their total cell number and differentiation status ...
Richard Ivell, Kee Heng, Katie Severn, Leen Antonio, Leen Antonio, Gyorgy Bartfai, Felipe F. Casanueva, Ilpo T. Huhtaniemi, Aleksander Giwercman, Mario Maggi, Daryl B. O’Connor, Terence W. O’Neill, Margus Punab, Giulia Rastrelli, Jolanta Slowikowska-Hilczer, Jos Tournoy, Dirk Vanderschueren, Dirk Vanderschueren, Frederick C. W. Wu, Ravinder Anand-Ivell   +19 more
doaj   +1 more source

Analysis of reproductive hormones and morphometric attributes in Thamankaduwa White male cattle

Cluj Veterinary Journal, 2023
Despite a few attempts in exploring genetic variability, management systems, and morphometric descriptions, Thamankaduwa White cattle in Sri Lanka has not been subjected to any evaluation of their endocrinological distinctiveness, especially related to ...
Siriwardana Tharinda Dhilshan De Silva, Oshan Bimsara Gunawardena, Mylvaganam Pagthinathan, Pradeepa Silva, Indunil Pathirana   +4 more
doaj   +3 more sources