Results 11 to 20 of about 2,190 (162)

Expression and Role of INSL3 in the Fetal Testis

Frontiers in Endocrinology, 2022
Insulin-like peptide 3 (INSL3) is a small peptide hormone of the insulin-relaxin family which is produced and secreted by the fetal Leydig cells in the testes only. It appears to be undetectable in female fetuses.
Richard Ivell, Linn Salto Mamsen, Claus Yding Andersen, Ravinder Anand-Ivell   +3 more
doaj   +5 more sources

INSL3 Expression in Leydig Cells is a Biomarker for Immunocastration in Boars: Transcriptional Evidence. [PDF]

Andrology
ABSTRACT Background Study aimed to obtain insights into physiological responses to immunocastration in pubertal boars by evaluating effects of alternative vaccination protocols and identifying a reliable immunocastration biomarker. Objectives It was hypothesized that the timing of gonadotropin‐releasing hormone (GnRH) suppression by immunocastration ...
Lukač NB, Škrlep M, Poklukar K, Ferjan P, Stefanski V, Fazarinc G, Vrecl M.   +6 more
europepmc   +7 more sources

The impact of breast milk relaxin 2, oxytocin, and insulin-like peptide 3 on neonatal growth parameters in early life. [PDF]

J Pediatr Gastroenterol Nutr
Abstract Objectives This study aims to quantify the levels of relaxin 2 (RLX2), oxytocin (OXT), and insulin‐like peptide 3 (INSL3) in colostrum (postpartum days 1–5, Visit 1) and mature breast milk (postpartum days 21–35, Visit 2), and to evaluate their associations with neonatal growth outcomes.
Doneray H, Ozden A, Tavlas G, Ozkan HI.
europepmc   +2 more sources

Maternal, childhood and adolescent influences on Leydig cell functional capacity and circulating INSL3 concentration in young adults: Importance of childhood infections and body mass index. [PDF]

Andrology
Abstract Background The constitutive Leydig cell hormone insulin‐like peptide 3 (INSL3) is considered a good estimate of the adult Leydig cell functional capacity and appears to remain relatively consistent throughout adult male life, only gradually declining into old age.
Ivell R, Tulumcu B, Alhujaili W, Anand-Ivell R.   +3 more
europepmc   +2 more sources

INSL3 in the ruminant: a powerful indicator of gender- and genetic-specific feto-maternal dialogue. [PDF]

PLoS ONE, 2011
The hormone Insulin-like peptide 3 (INSL3) is a major secretory product of the Leydig cells from both fetal and adult testes. Consequently, it is a major gender-specific circulating hormone in the male fetus, where it is responsible for the first phase ...
Ravinder Anand-Ivell, Stefan Hiendleder, Carolina Viñoles, Graeme B Martin, Carolyn Fitzsimmons, Andrea Eurich, Bettina Hafen, Richard Ivell   +7 more
doaj   +1 more source

The Leydig cell biomarker INSL3 as a predictor of age-related morbidity: Findings from the EMAS cohort

Frontiers in Endocrinology, 2022
BackgroundInsulin-like peptide 3 (INSL3) is a constitutive hormone secreted in men by the mature Leydig cells of the testes. It is an accurate biomarker for Leydig cell functional capacity, reflecting their total cell number and differentiation status ...
Richard Ivell, Kee Heng, Katie Severn, Leen Antonio, Leen Antonio, Gyorgy Bartfai, Felipe F. Casanueva, Ilpo T. Huhtaniemi, Aleksander Giwercman, Mario Maggi, Daryl B. O’Connor, Terence W. O’Neill, Margus Punab, Giulia Rastrelli, Jolanta Slowikowska-Hilczer, Jos Tournoy, Dirk Vanderschueren, Dirk Vanderschueren, Frederick C. W. Wu, Ravinder Anand-Ivell   +19 more
doaj   +1 more source

Mass Spectrometry Supports That the Structure of Circulating Human Insulin-Like Factor 3 Is a Heterodimer

Frontiers in Endocrinology, 2020
The structure of the testicular peptide hormone insulin-like factor 3 (INSL3) has been the subject of discussion for more than a decade. Some studies support that the central C-domain of INSL3 is proteolytically removed and that INSL3 is secreted by the ...
Jakob Albrethsen, Jakob Albrethsen, Anders Juul, Anders Juul, Anna-Maria Andersson, Anna-Maria Andersson   +5 more
doaj   +1 more source

The RXFP2-PLC/PKC signaling pathway mediates INSL3-induced regulation of the proliferation, migration and apoptosis of mouse gubernacular cells

Cellular & Molecular Biology Letters, 2023
Background Testicular hypoplasia can affect the sexual and reproductive ability in adulthood, and even increase the risk of cancer. Abnormal development of the gubernaculum is one of the important factors of testicular hypoplasia.
Shouxing Duan, Xuewu Jiang, Jianhong Li, Maxian Fu, Zhuo Li, Yiyi Cheng, Yangmu Zhuang, Ming Yang, Wenfeng Xiao, Hongyan Ping, Yao Xie, Xiaojun Xie, Xuan Zhang   +12 more
doaj   +1 more source

Cryptorchidism: Novel genetic insights into CCDC149 mutations. [PDF]

Andrology
Abstract Background Cryptorchidism, characterized by the failure of one or both testes to descend into the scrotum, is a common congenital condition that can lead to infertility and increased risk of testicular cancer. CCDC149, a coiled‐coil domain‐containing protein, has been implicated in various developmental processes, but its role in the male ...
Du S, Xu S, Yang L, Ye Y, Wu Y, Xiao Z, Dong X, Yao W, Li H.   +8 more
europepmc   +2 more sources

Insulin-like 3 affects zebrafish spermatogenic cells directly and via Sertoli cells

Communications Biology, 2021
Insulin-like 3 (Insl3) belongs to a class of peptide hormones that are expressed in the Leydig cells and, in zebrafish, under the control of folliclestimulating hormone (Fsh) in the pituitary.
Diego Crespo, Luiz H. C. Assis, Yu Ting Zhang, Diego Safian, Tomasz Furmanek, Kai Ove Skaftnesmo, Birgitta Norberg, Wei Ge, Yung-Ching Choi, Marjo J. den Broeder, Juliette Legler, Jan Bogerd, Rüdiger W. Schulz   +12 more
doaj   +1 more source