Insulin‐like peptide 3 in domestic animals with normal and abnormal reproductive functions, in comparison to rodents and humans [PDF]
Reproductive Medicine and Biology, 2022 Background Insulin‐like peptide 3 (INSL3) is a circulating hormone secreted from only testis and ovaries in mammals. Findings on INSL3 have been gathered from subjects with normal and abnormal reproductive statuses, especially rodents and humans. However,
Noritoshi Kawate
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Insulin-Like Peptide 3 (INSL3) Serum Concentration During Human Male Fetal Life [PDF]
Frontiers in Endocrinology, 2019 Context: Insulin-like peptide 3 (INSL3), a protein hormone produced by Leydig cells, may play a crucial role in testicular descent as male INSL3 knockout mice have bilateral cryptorchidism.
Steven M. Harrison +8 more
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Insulin-like peptide 3 is not a biomarker for pancreatic ductal adenocarcinoma [PDF]
Frontiers in EndocrinologyPancreatic ductal carcinoma (PDAC) is a rapidly growing cancer with a very poor prognosis. It is, therefore, important to develop novel, specific biomarkers to identify such cancers as early as possible.
Ravinder Anand-Ivell +5 more
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Quantitative analyses of insulin-like peptide 3 and sex steroid hormones in dominant follicles and corpora lutea during the estrus cycle and in follicular cysts in beef heifers [PDF]
The Journal of Reproduction and Development, 2022 Insulin-like peptide 3 (INSL3) and sex steroids were measured in bovine dominant follicles and corpora lutea during the estrus cycle and in follicular cysts.
Hewage Dilhan Anuradha WIMALARATHNE +2 more
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The structural determinants of insulin-like peptide 3 activity [PDF]
Frontiers in Endocrinology, 2012 INSL3 is a hormone and/or paracrine factor which is a member of the relaxin peptide family. It has key roles as a fertility regulator in both males and females. The receptor for INSL3 is the leucine rich repeat (LRR) containing G-protein coupled receptor
Ross AD Bathgate +5 more
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Distinct activation modes of the Relaxin Family Peptide Receptor 2 in response to insulin-like peptide 3 and relaxin [PDF]
Scientific Reports, 2017 Relaxin family peptide receptor 2 (RXFP2) is a GPCR known for its role in reproductive function. It is structurally related to the human relaxin receptor RXFP1 and can be activated by human gene-2 (H2) relaxin as well as its cognate ligand insulin-like ...
Shoni Bruell +9 more
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Insulin-like peptide 3 (INSL3) in congenital hypogonadotrophic hypogonadism (CHH) in boys with delayed puberty and adult men [PDF]
Frontiers in Endocrinology, 2022 BackgroundDelayed puberty in males is almost invariably associated with constitutional delay of growth and puberty (CDGP) or congenital hypogonadotrophic hypogonadism (CHH).
Ali Abbara +30 more
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Generation of a heterozygous C-peptide-mCherry reporter human iPSC line (HMGUi001-A-8)
Stem Cell Research, 2021 The peptide hormone insulin produced by pancreatic β-cells undergoes post-transcriptional processing before secretion. In particular, C-peptide is cleaved from pro-insulin to generate mature insulin. Here, we introduce a C-peptide-mCherry human iPSC line
Johanna Siehler +7 more
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Gubernaculum and Epididymo-Testicular Descent: Review of the Literature
Acta Medica Lituanica, 2022 Cryptorchidism is a common disorder in boys that has been widely studied both experimentally and clinically. The role of the gubernaculum, a mesenchymal tissue extending from the fetal testis and epididymis to the developing scrotum, is still unclear ...
Eleonora Ivanova +3 more
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Frontiers in Endocrinology, 2021 ObjectiveNon-alcoholic fatty liver disease is highly prevalent in patients with type 2 diabetes mellitus. Studies on glucagon-like peptide-1 receptor agonists for the treatment of non-alcoholic fatty liver disease have reported promising results. Despite
Chloe Wong +12 more
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