Insulin-Like Peptide 3 (INSL3) Serum Concentration During Human Male Fetal Life [PDF]
Frontiers in Endocrinology, 2019 Context: Insulin-like peptide 3 (INSL3), a protein hormone produced by Leydig cells, may play a crucial role in testicular descent as male INSL3 knockout mice have bilateral cryptorchidism.
Steven M. Harrison +8 more
doaj +3 more sources
Insulin‐like peptide 3 in domestic animals with normal and abnormal reproductive functions, in comparison to rodents and humans [PDF]
Reproductive Medicine and Biology, 2022 Background Insulin‐like peptide 3 (INSL3) is a circulating hormone secreted from only testis and ovaries in mammals. Findings on INSL3 have been gathered from subjects with normal and abnormal reproductive statuses, especially rodents and humans. However,
Noritoshi Kawate
doaj +3 more sources
The structural determinants of insulin-like peptide 3 activity [PDF]
Frontiers in Endocrinology, 2012 INSL3 is a hormone and/or paracrine factor which is a member of the relaxin peptide family. It has key roles as a fertility regulator in both males and females. The receptor for INSL3 is the leucine rich repeat (LRR) containing G-protein coupled receptor
Ross AD Bathgate +5 more
doaj +4 more sources
Insulin-like peptide 3 (INSL3) in congenital hypogonadotrophic hypogonadism (CHH) in boys with delayed puberty and adult men [PDF]
Frontiers in Endocrinology, 2022 BackgroundDelayed puberty in males is almost invariably associated with constitutional delay of growth and puberty (CDGP) or congenital hypogonadotrophic hypogonadism (CHH).
Ali Abbara +30 more
doaj +4 more sources
Quantitative analyses of insulin-like peptide 3 and sex steroid hormones in dominant follicles and corpora lutea during the estrus cycle and in follicular cysts in beef heifers [PDF]
The Journal of Reproduction and Development, 2022 Insulin-like peptide 3 (INSL3) and sex steroids were measured in bovine dominant follicles and corpora lutea during the estrus cycle and in follicular cysts.
Hewage Dilhan Anuradha WIMALARATHNE +2 more
doaj +4 more sources
Distinct activation modes of the Relaxin Family Peptide Receptor 2 in response to insulin-like peptide 3 and relaxin [PDF]
Scientific Reports, 2017 Relaxin family peptide receptor 2 (RXFP2) is a GPCR known for its role in reproductive function. It is structurally related to the human relaxin receptor RXFP1 and can be activated by human gene-2 (H2) relaxin as well as its cognate ligand insulin-like ...
Shoni Bruell +9 more
doaj +4 more sources
Adult Human Biliary Tree Stem Cells Differentiate to β-Pancreatic Islet Cells by Treatment with a Recombinant Human Pdx1 Peptide. [PDF]
PLoS ONE, 2015 Generation of β-pancreatic cells represents a major goal in research. The aim of this study was to explore a protein-based strategy to induce differentiation of human biliary tree stem cells (hBTSCs) towards β-pancreatic cells.
Vincenzo Cardinale +15 more
doaj +14 more sources
Insulin-like peptide 3 is not a biomarker for pancreatic ductal adenocarcinoma [PDF]
Frontiers in EndocrinologyPancreatic ductal carcinoma (PDAC) is a rapidly growing cancer with a very poor prognosis. It is, therefore, important to develop novel, specific biomarkers to identify such cancers as early as possible.
Ravinder Anand-Ivell +5 more
doaj +2 more sources
Influence on the adult male Leydig cell biomarker insulin-like peptide 3 of maternal exposure to estrogenic and anti-androgenic endocrine disrupting compound mixtures: A retrospective study. [PDF]
Andrologia, 2022 Ivell R +3 more
europepmc +3 more sources
Effects of Psyllium Husk on Metabolic Regulators, Insulin Resistance, and SIRT6 in Liver and Muscle of Type 2 Diabetic Rats [PDF]
Veterinary Medicine and ScienceBackground Type 2 diabetes mellitus (T2DM) is a common metabolic disorder marked by insulin resistance, impaired insulin secretion, oxidative stress, and dysregulated appetite and energy balance.
Furkan Ümit +5 more
doaj +2 more sources