Insulin-Like Peptides and Cross-Talk With Other Factors in the Regulation of Insect Metabolism
Frontiers in Physiology, 2021 The insulin-like peptide (ILP) and insulin-like growth factor (IGF) signalling pathways play a crucial role in the regulation of metabolism, growth and development, fecundity, stress resistance, and lifespan.
Szymon Chowański +6 more
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Journal of Diabetes Research, 2023 Background. Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) are potent antihyperglycemic agents with beneficial effects on weight, cardiovascular, and renal outcomes.
Colleen Gavigan, Thomas Donner
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Defining the LGR8 Residues Involved in Binding Insulin-Like Peptide 3 [PDF]
Molecular Endocrinology, 2007 Abstract The peptide hormone insulin-like peptide 3 (INSL3) is essential for testicular descent and has been implicated in the control of adult fertility in both sexes. The human INSL3 receptor leucine-rich repeat-containing G protein-coupled receptor 8 (LGR8) binds INSL3 and relaxin with high affinity, whereas the relaxin receptor LGR7 ...
Scott, DJ +6 more
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The Daily Profiles of Circulating AMH and INSL3 in Men are Distinct from the Other Testicular Hormones, Inhibin B and Testosterone. [PDF]
PLoS ONE, 2015 The testes secrete four hormones (anti-Müllerian hormone, insulin-like peptide 3, Inhibin B and testosterone) from two endocrine cell types. It is unknown whether anti-Müllerian hormone and insulin-like peptide 3 levels have a diurnal variation, and if ...
Yih Harng Chong +2 more
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Aquaculture Reports, 2022 The insulin-like androgenic gland-specific peptide is a known primary regulator of sexual differentiation in crustaceans. However, the knowledge of the crucial elements involved in the insulin-like signaling cascade remains fragmented.
Yi-Lai Chen +6 more
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Expression of the Insulin-Like Peptide 3 (INSL3) Hormone-Receptor (LGR8) System in the Testis1 [PDF]
Biology of Reproduction, 2006 Ravinder Anand‐Ivell +6 more
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Research progress of insulin-like peptide 3 in bone metabolism [PDF]
Mengting Zhou +6 more
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Cord blood Insulin‐like peptide 3 (
Clinical Endocrinology, 2014 SummaryBackgroundCryptorchidism, the most frequent congenital malformation in full‐term male newborns, increases the risk of hypofertility and testicular cancer. Most cases remain idiopathic but epidemiological and experimental studies have suggested a role of both genetic and environmental factors.
Fénichel, Patrick +5 more
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Combination GLP-1 and Insulin Treatment Fails to Alter Myocardial Fuel Selection Versus Insulin Alone in Type 2 Diabetes [PDF]
, 2018 Context Glucagon-like peptide-1 (GLP-1) and the clinically available GLP-1 agonists have been shown to exert effects on the heart. It is unclear whether these effects occur at clinically used doses in vivo in humans, possibly contributing to CVD risk ...
Considine, Robert V. +9 more
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Solution Structure and Characterization of the LGR8 Receptor Binding Surface of Insulin-like Peptide 3 [PDF]
Journal of Biological Chemistry, 2006 Insulin-like peptide 3 (INSL3), a member of the relaxin peptide family, is produced in testicular Leydig cells and ovarian thecal cells. Gene knock-out experiments have identified a key biological role in initiating testes descent during fetal development.
Rosengren, K. J. +8 more
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