Results 11 to 20 of about 339,703 (317)

Relaxin and insulin-like peptide 3 in the musculoskeletal system: from bench to bedside. [PDF]

Br J Pharmacol, 2017
Skeletal muscles and bones form a joined functional unit sharing a complex mechanical, biochemical and hormonal crosstalk. A number of factors, including sex hormones, physiologically regulate the musculoskeletal system. Striking gender differences in muscle and bone mass, and function are mainly caused by distinct actions exerted by oestrogens and ...
Ferlin A, Ferlin A, De Toni L, Sandri M, Foresta C.   +4 more
europepmc   +7 more sources

Insulin-like peptide 3 expressed in the silkworm possesses intrinsic disulfide bonds and full biological activity. [PDF]

Sci Rep, 2017
AbstractInsulin-like peptide 3 (INSL3) is a member of the relaxin/insulin superfamily and is expressed in testicular Leydig cells. Essential for fetal testis descent, INSL3 has been implicated in testicular and sperm function in adult males via interaction with relaxin/insulin-like family peptide receptor 2 (RXFP2).
Miyazaki T, Ishizaki M, Dohra H, Park S, Terzic A, Kato T, Kohsaka T, Park EY.   +7 more
europepmc   +5 more sources

Blood feeding and insulin-like peptide 3 stimulate proliferation of hemocytes in the mosquito Aedes aegypti. [PDF]

PLoS Pathogens, 2011
All vector mosquito species must feed on the blood of a vertebrate host to produce eggs. Multiple cycles of blood feeding also promote frequent contacts with hosts, which enhance the risk of exposure to infectious agents and disease transmission.
Julio Castillo, Mark R Brown, Michael R Strand   +2 more
doaj   +4 more sources

Associations of serum C-peptide and insulin-like growth factor binding proteins-3 with breast cancer deaths.

PLoS ONE, 2020
C-peptide is usually considered as a marker of insulin secretion and has no physiological function. This study aimed to assess the association between serum C-peptide level as independent risk factor and breast cancer and explored the possible underlying
PinYu Cui, Yuan Chen, Nuremaguli Waili, YaXing Li, CuiLing Ma, Ying Li   +5 more
doaj   +4 more sources

GREAT/LGR8 Is the Only Receptor for Insulin-Like 3 Peptide [PDF]

Molecular Endocrinology, 2003
During male development testes descend from their embryonic intraabdominal position into the scrotum. Two genes, encoding the insulin-like 3 peptide (INSL3) and the GREAT/LGR8 G protein-coupled receptor, control the differentiation of gubernaculum, the caudal genitoinguinal ligament critical for testicular descent.
Natalia V. Bogatcheva, Anne Truong, Shu Feng, Wolfgang Engel, Ibrahim M. Adham, Alexander I. Agoulnik   +5 more
openalex   +4 more sources

New Insights into the Mechanism of Insulin-like Peptide 3 (<i>INSL3</i>) Regulating the Growth and Development of <i>Bovine</i> Follicular Granulosa Cells. [PDF]

Int J Mol Sci
Li H, He F, Li X, Nie J, Khan HA, Chen C, Hua J.   +6 more
europepmc   +3 more sources

Insulin-like peptide 3 (INSL3) is a major regulator of female reproductive physiology [PDF]

Human Reproduction Update, 2018
Insulin-like peptide 3 (INSL3) is a member of the relaxin family of neohormones which has evolved to address specifically mammalian aspects of reproduction related to viviparity and internal fertilization. It was originally identified as a major product of testicular Leydig cells and has proved to be an important biomarker of Leydig cell functional ...
Richard Ivell, Ravinder Anand‐Ivell
openalex   +3 more sources

Diverse functions of insulin-like 3 peptide [PDF]

Journal of Endocrinology, 2020
Insulin-like 3 peptide (INSL3) is a member of the insulin-like peptide superfamily and is the only known physiological ligand of relaxin family peptide receptor 2 (RXFP2), a G protein-coupled receptor (GPCR). In mammals, INSL3 is primarily produced both in testicular Leydig cells and in ovarian theca cells, but circulating levels of the hormone are ...
María Esteban-López, Alexander I. Agoulnik   +1 more
openalex   +3 more sources

Insulin-like peptide 3 stimulates hemocytes to proliferate in anautogenous and facultatively autogenous mosquitoes.

J Exp Biol, 2022
ABSTRACTMost mosquito species are anautogenous, which means they must blood feed on a vertebrate host to produce eggs, while a few are autogenous and can produce eggs without blood feeding. Egg formation is best understood in the anautogenous mosquito Aedes aegypti, where insulin-like peptides (ILPs), ovary ecdysteroidogenic hormone (OEH) and 20 ...
Martinson EO, Chen K, Valzania L, Brown MR, Strand MR.   +4 more
europepmc   +3 more sources

Cooperative Binding of Insulin-Like Peptide 3 to a Dimeric Relaxin Family Peptide Receptor 2 [PDF]

Endocrinology, 2007
Insulin-like peptide 3 (INSL3) binds to a G protein-coupled receptor (GPCR) called relaxin family peptide receptor 2 (RXFP2). RXFP2 belongs to the leucine-rich repeat-containing subgroup (LGR) of class A GPCRs. Negative cooperativity has recently been demonstrated in other members of the LGR subgroup.
Angela Manegold Svendsen, Milka Vrecl, Tina M. Ellis, Anders Heding, Jesper B. Kristensen, John D. Wade, Ross A. D. Bathgate, Pierre De Meyts, Jane Nøhr   +8 more
openalex   +3 more sources