Results 21 to 30 of about 22,902,059 (175)
Journal of Diabetes Research, 2023 Background. Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) are potent antihyperglycemic agents with beneficial effects on weight, cardiovascular, and renal outcomes.
Colleen Gavigan, Thomas Donner
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Insulin-like peptide 3 expressed in the silkworm possesses intrinsic disulfide bonds and full biological activity. [PDF]
Sci Rep, 2017 AbstractInsulin-like peptide 3 (INSL3) is a member of the relaxin/insulin superfamily and is expressed in testicular Leydig cells. Essential for fetal testis descent, INSL3 has been implicated in testicular and sperm function in adult males via interaction with relaxin/insulin-like family peptide receptor 2 (RXFP2).
Miyazaki T +7 more
europepmc +4 more sources
Defining the LGR8 Residues Involved in Binding Insulin-Like Peptide 3 [PDF]
Molecular Endocrinology, 2007 Abstract The peptide hormone insulin-like peptide 3 (INSL3) is essential for testicular descent and has been implicated in the control of adult fertility in both sexes. The human INSL3 receptor leucine-rich repeat-containing G protein-coupled receptor 8 (LGR8) binds INSL3 and relaxin with high affinity, whereas the relaxin receptor LGR7 ...
Scott, DJ +6 more
openaire +3 more sources
The Daily Profiles of Circulating AMH and INSL3 in Men are Distinct from the Other Testicular Hormones, Inhibin B and Testosterone. [PDF]
PLoS ONE, 2015 The testes secrete four hormones (anti-Müllerian hormone, insulin-like peptide 3, Inhibin B and testosterone) from two endocrine cell types. It is unknown whether anti-Müllerian hormone and insulin-like peptide 3 levels have a diurnal variation, and if ...
Yih Harng Chong +2 more
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Aquaculture Reports, 2022 The insulin-like androgenic gland-specific peptide is a known primary regulator of sexual differentiation in crustaceans. However, the knowledge of the crucial elements involved in the insulin-like signaling cascade remains fragmented.
Yi-Lai Chen +6 more
doaj +1 more source
Cooperative Binding of Insulin-Like Peptide 3 to a Dimeric Relaxin Family Peptide Receptor 2 [PDF]
Endocrinology, 2007 Insulin-like peptide 3 (INSL3) binds to a G protein-coupled receptor (GPCR) called relaxin family peptide receptor 2 (RXFP2). RXFP2 belongs to the leucine-rich repeat-containing subgroup (LGR) of class A GPCRs. Negative cooperativity has recently been demonstrated in other members of the LGR subgroup.
Angela Manegold, Svendsen +8 more
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Insulin-like peptide 3 (INSL3) is a major regulator of female reproductive physiology [PDF]
Human Reproduction Update, 2018 Insulin-like peptide 3 (INSL3) is a member of the relaxin family of neohormones which has evolved to address specifically mammalian aspects of reproduction related to viviparity and internal fertilization. It was originally identified as a major product of testicular Leydig cells and has proved to be an important biomarker of Leydig cell functional ...
Richard Ivell, Ravinder Anand-Ivell
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Cord blood Insulin‐like peptide 3 (
Clinical Endocrinology, 2014 SummaryBackgroundCryptorchidism, the most frequent congenital malformation in full‐term male newborns, increases the risk of hypofertility and testicular cancer. Most cases remain idiopathic but epidemiological and experimental studies have suggested a role of both genetic and environmental factors.
Fénichel, Patrick +5 more
openaire +3 more sources
Mechanism for insulin-like peptide 5 distinguishing the homologous relaxin family peptide receptor 3 and 4 [PDF]
Scientific Reports, 2016 AbstractThe relaxin family peptides play a variety of biological functions by activating four G protein-coupled receptors, RXFP1–4. Among them, insulin-like peptide 5 (INSL5) and relaxin-3 share the highest sequence homology, but they have distinct receptor preference: INSL5 can activate RXFP4 only, while relaxin-3 can activate RXFP3, RXFP4 and RXFP1 ...
Meng-Jun Hu +7 more
openaire +2 more sources
Cyclic AMP signalling in pancreatic islets [PDF]
, 2010 Cyclic 3'5'AMP (cAMP) is an important physiological amplifier of glucose-induced insulin secretion by the pancreatic islet β-cell, where it is formed by the activity of adenylyl cyclases, which are stimulated by glucose, through elevation in ...
Pyne, Nigel J. +2 more
core +4 more sources