Anti-Müllerian Hormone and Inhibin-A, but not Inhibin-B or Insulin-Like Peptide-3, may be Used as Surrogates in the Diagnosis of Polycystic Ovary Syndrome in Adolescents: Preliminary Results. [PDF]
J Clin Res Pediatr Endocrinol, 2016 Yetim A +6 more
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Mechanism for insulin-like peptide 5 distinguishing the homologous relaxin family peptide receptor 3 and 4 [PDF]
Scientific Reports, 2016 AbstractThe relaxin family peptides play a variety of biological functions by activating four G protein-coupled receptors, RXFP1–4. Among them, insulin-like peptide 5 (INSL5) and relaxin-3 share the highest sequence homology, but they have distinct receptor preference: INSL5 can activate RXFP4 only, while relaxin-3 can activate RXFP3, RXFP4 and RXFP1 ...
Mengjun Hu +7 more
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Relaxin‐3/insulin‐like peptide 7, a neuropeptide involved in the stress response and food intake [PDF]
The FEBS Journal, 2010 Relaxin‐3, also known as insulin‐like peptide‐7, is a newly‐identified peptide of the insulin superfamily. All members of this superfamily have a similar structure, which consists of two subunits (A‐chain and B‐chain) linked by disulfide bonds. Relaxin‐3 is so named because it has a motif that can interact with the relaxin receptor.
Masaki Tanaka
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Expression of insulin-like peptide 3 in the postnatal rat Leydig cell lineage: timing and effects of triiodothyronine-treatment [PDF]
Reproduction, 2007 Abstract Fetal (FLC) and adult Leydig cells (ALC) secrete insulin-like peptide 3 (INSL3), which is linked to cryptorchidism in the newborn rat. Its gene regulation appears to be independent of that for most steroidogenic enzymes, and may thus be a marker for other aspects of ALC differentiation.
S.M.L.C. Mendis-Handagama +3 more
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Generation of a heterozygous C-peptide-mCherry reporter human iPSC line (HMGUi001-A-8)
Stem Cell Research, 2021 The peptide hormone insulin produced by pancreatic β-cells undergoes post-transcriptional processing before secretion. In particular, C-peptide is cleaved from pro-insulin to generate mature insulin. Here, we introduce a C-peptide-mCherry human iPSC line
Johanna Siehler +7 more
doaj +1 more source
Study of the insulin-like peptide 3 in human platelets
, 2009 The insulin-like 3 peptide is autocrine/paracrine insulin-related hormone with a size of approximately 6kDa [1]. It mediates through a leucine richG-coupled receptor named LGR8. INSL3 is mainly expressed in human Leydig cells and is directly responsible for migration of the testis during the pre-natal period in maledevelopment.
Mathias Borg
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Recombinant expression of an insulin‐like peptide 3 (INSL3) precursor and its enzymatic conversion to mature human INSL3 [PDF]
The FEBS Journal, 2009 Insulin‐like peptide 3 (INSL3), which is primarily expressed in the Leydig cells of the testes, is a member of the insulin superfamily of peptide hormones. One of its primary functions is to initiate and mediate descent of the testes of the male fetus via interaction with its G protein‐coupled receptor, RXFP2.
Xiao Luo +5 more
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Gubernaculum and Epididymo-Testicular Descent: Review of the Literature
Acta Medica Lituanica, 2022 Cryptorchidism is a common disorder in boys that has been widely studied both experimentally and clinically. The role of the gubernaculum, a mesenchymal tissue extending from the fetal testis and epididymis to the developing scrotum, is still unclear ...
Eleonora Ivanova +3 more
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Frontiers in Endocrinology, 2021 ObjectiveNon-alcoholic fatty liver disease is highly prevalent in patients with type 2 diabetes mellitus. Studies on glucagon-like peptide-1 receptor agonists for the treatment of non-alcoholic fatty liver disease have reported promising results. Despite
Chloe Wong +12 more
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