Results 31 to 40 of about 4,038 (203)

Insulin-Like Peptide 3 (INSL3) Serum Concentration During Human Male Fetal Life

Frontiers in Endocrinology, 2019
Context: Insulin-like peptide 3 (INSL3), a protein hormone produced by Leydig cells, may play a crucial role in testicular descent as male INSL3 knockout mice have bilateral cryptorchidism.
Steven M. Harrison, Nicol Corbin Bush, Yi Wang, Zachary R. Mucher, Armando J. Lorenzo, Gwen M. Grimsby, Bruce J. Schlomer, Erika E. Büllesbach, Linda A. Baker   +8 more
doaj   +1 more source

Insulin-like 3 affects zebrafish spermatogenic cells directly and via Sertoli cells

Communications Biology, 2021
Insulin-like 3 (Insl3) belongs to a class of peptide hormones that are expressed in the Leydig cells and, in zebrafish, under the control of folliclestimulating hormone (Fsh) in the pituitary.
Diego Crespo, Luiz H. C. Assis, Yu Ting Zhang, Diego Safian, Tomasz Furmanek, Kai Ove Skaftnesmo, Birgitta Norberg, Wei Ge, Yung-Ching Choi, Marjo J. den Broeder, Juliette Legler, Jan Bogerd, Rüdiger W. Schulz   +12 more
doaj   +1 more source

Cryptorchidism in the orl rat is associated with muscle patterning defects in the fetal gubernaculum and altered hormonal signaling [PDF]

, 2014
Cryptorchidism, or undescended testis, is a common male genital anomaly of unclear etiology. Hormonal stimulation of the developing fetal gubernaculum by testicular androgens and insulin-like 3 (INSL3) is required for testicular descent.
Abigail Mateson, Alan Robbins, Joan Pugarelli, Julia S. Barthold, Rat Genome Database Web Site, Medical College of Wisconsin, Milwaukee, WI, Ravinder Anand-Ivell, Richard Ivell, Robert E. Akins, Suzanne M. McCahan, Yanping Wang   +9 more
core   +1 more source

Hormonal control of gubernaculum development during testis descent: gubernaculum outgrowth in vitro requires both insulin-like factor and androgen [PDF]

, 2000
The gubernaculum connects the gonad to the inguinoscrotal region and is involved in testis descent. It rapidly develops in the male fetus, whereas development in the female fetus is lacking.
Adham, I.M., Brinkmann, A.O. (Albert), Emmen, J.M.A. (Judith), Engel, W., Grootegoed, J.A. (Anton), McLuskey, A.   +5 more
core   +1 more source

Perfluorooctane sulfonate concentrations in amniotic fluid, biomarkers of fetal Leydig cell function, and cryptorchidism and hypospadias in Danish boys (1980–1996) [PDF]

, 2016
Background: Exposure to perfluorooctane sulfonate (PFOS) may potentially disturb fetal Leydig cell hormone production and male genital development. Objectives: We aimed to study the associations between levels of amniotic fluid PFOS, fetal steroid ...
Anand-Ivell R, Arieh Cohen, Bent Nørgaard-Pedersen, Bo A.G. Jönsson, Christian H. Lindh, David M. Hougaard, European Commission., Gunnar Toft, Jauniaux E, Jens Peter Bonde, Knudsen LB, Morten S. Lindhard, Pedersen CB, Ravinder Anand-Ivell, Richard Ivell   +14 more
core   +2 more sources

Insulin-like factor 3 and the HPG axis in the male [PDF]

, 2014
The hypothalamic–pituitary–gonadal (HPG) axis comprises pulsatile GnRH from the hypothalamus impacting on the anterior pituitary to induce expression and release of both LH and FSH into the circulation.
Anand-Ivell, Ravinder, Heng, Kee, Ivell, Richard   +2 more
core   +3 more sources

New JAK3-INSL3 Fusion Transcript—An Oncogenic Event in Cutaneous T-Cell Lymphoma

Cells, 2023
Constitutively activated tyrosine kinase JAK3 is implicated in the pathogenesis of cutaneous T-cell lymphomas (CTCL). The mechanisms of constitutive JAK3 activation are unknown although a JAK3 mutation was reported in a small portion of CTCL patients. In
Loka Reddy Velatooru, Cheng Hui Hu, Pedram Bijani, Xiaohong Wang, Pierr Bojaxhi, Hao Chen, Madeleine Duvic, Xiao Ni   +7 more
doaj   +1 more source

Total chemical synthesis of a heterodimeric interchain Bis-Lactam-linked peptide: application to an analogue of human insulin-like peptide 3 [PDF]

, 2013
Nonreducible cystine isosteres represent important peptide design elements in that they can maintain a near-native tertiary conformation of the peptide while simultaneously extending the in vitro and in vivo half-life of the biomolecule.
Gardiner, J., Hossain, M., Karas, J., Scanlon, D., Separovic, F., Shabanpoor, F., Wade, J.   +6 more
core   +3 more sources

Targeted Disruption of the Insl3 Gene Causes Bilateral Cryptorchidism [PDF]

Molecular Endocrinology, 1999
AbstractThe sexual dimorphic position of the gonads in mammals is dependent on differential development of two ligaments, the cranial suspensory ligament (CSL) and the gubernaculum. During male embryogenesis, outgrowth of the gubernaculum and regression of the CSL result in transabdominal descent of the testes, whereas in the female, development of the
Zimmermann, S, Steding, G, Emmen, JMA (Judith), Brinkmann, Albert, Nayernia, K, Holstein, AF, Engel, W, Adham, IM   +7 more
openaire   +3 more sources

Expression of Insl3 Protein in Adult Danio rerio. [PDF]

Int J Mol Sci
Insulin-like peptide 3 (INSL3) is a biomarker for Leydig cells in the testes of vertebrates, and it is principally involved in spermatogenesis through specific binding with the RXFP2 receptor. This study reports the insl3 gene transcript and the Insl3 prepropeptide expression in both non-reproductive and reproductive tissues of Danio rerio.
Donizetti A, Calicchio M, Romano MZ, Rosati L, Turco M, Carrese AM, Del Gaudio R, Ferrandino I, Aniello F.   +8 more
europepmc   +4 more sources