Results 31 to 40 of about 2,190 (162)

Origin of INSL3-mediated testicular descent in therian mammals [PDF]

Genome Research, 2008
Testicular descent is a unique physiological adaptation found in therian mammals allowing optimal spermatogenesis below core body temperature. Recent studies show that INSL3, produced by Leydig cells, and its receptor LGR8 (RXFP2) are essential for mediating the transabdominal phase of testicular descent during early development ...
Park, Jae-Il, Semyonov, Jenia, Chang, Chia Lin, Yi, Wei, Warren, Wesley, Hsu, Sheau Yu Teddy   +5 more
openaire   +3 more sources

Endothelial PDGF Signaling Dysregulation Impairs Testicular Interstitial Homeostasis in Diabetes. [PDF]

Adv Sci (Weinh)
Testicular endothelial cells (TECs) function as central signaling hubs that coordinate interstitial homeostasis. Diabetes disrupts TEC‐derived PDGF signaling, silences the JUND‐MCL1 survival program in Leydig cells, and impairs peritubular function, leading to fibrosis and testosterone insufficiency.
Zhang W, Hong K, Tang Y, Cui L, Lu X, Cheng J, Fang Y, Jiang Q, Zhuang Z, Gao S, Jiang H, Liu Q, Guo J, Zhang Z, Wang X.   +14 more
europepmc   +2 more sources

Leydig cell metabolic disorder act as a new mechanism affecting for focal spermatogenesis in Klinefelter syndrome patients: a real world cross-sectional study base on the age

Frontiers in Endocrinology, 2023
BackgroundKlinefelter’s syndrome (KS) was once considered infertile due to congenital chromosomal abnormalities, but the presence of focal spermatozoa changed this.
Huang Liu, Zhenhui Zhang, Yong Gao, Hai Lin, Zhiyong Zhu, Houbin Zheng, Wenjing Ye, Zefang Luo, Zhaohui Qing, Xiaolan Xiao, Lei Hu, Yu Zhou, Xinzong Zhang   +12 more
doaj   +1 more source

Role of INSL3 and LGR8 in cryptorchidism and testicular functions

Reproductive BioMedicine Online, 2004
Cryptorchidism is the most frequent congenital anomaly of the urogenital tract in human males. INSL3 and LGR8/GREAT proteins seem to act as ligand and receptor respectively, and to have a role in gubernaculum development involved in testicular descent.
FORESTA, CARLO, FERLIN, ALBERTO
openaire   +3 more sources

Expression of insulin-like 3 (INSL3) and differential splicing of its receptor in the ovary of rhesus macaques

Reproductive Biology and Endocrinology, 2010
Background Although insulin-like 3 (INSL3) has been identified in the gonad of both sexes in many species, there are only limited reports on the distribution of INSL3 and its receptor, relaxin/insulin-like family peptide receptor 2 (RXFP2), in the ...
Jensen Jeffrey T, Patta Maristela C, Yao Shan, Hanna Carol B, Wu Xuemei   +4 more
doaj   +1 more source

Insulin-like peptide 3 (INSL3) in congenital hypogonadotrophic hypogonadism (CHH) in boys with delayed puberty and adult men

Frontiers in Endocrinology, 2022
BackgroundDelayed puberty in males is almost invariably associated with constitutional delay of growth and puberty (CDGP) or congenital hypogonadotrophic hypogonadism (CHH).
Ali Abbara, Ali Abbara, Kanyada Koysombat, Maria Phylactou, Maria Phylactou, Pei Chia Eng, Pei Chia Eng, Sophie Clarke, Sophie Clarke, Alexander N. Comninos, Alexander N. Comninos, Lisa Yang, Lisa Yang, Chioma Izzi-Engbeaya, Chioma Izzi-Engbeaya, Simon Hanassab, Simon Hanassab, Neil Smith, Channa N. Jayasena, Channa N. Jayasena, Cheng Xu, Cheng Xu, Richard Quinton, Richard Quinton, Nelly Pitteloud, Nelly Pitteloud, Gerhard Binder, Ravinder Anand-Ivell, Richard Ivell, Waljit S. Dhillo, Waljit S. Dhillo   +30 more
doaj   +1 more source

Targeted Disruption of the Insl3 Gene Causes Bilateral Cryptorchidism [PDF]

Molecular Endocrinology, 1999
AbstractThe sexual dimorphic position of the gonads in mammals is dependent on differential development of two ligaments, the cranial suspensory ligament (CSL) and the gubernaculum. During male embryogenesis, outgrowth of the gubernaculum and regression of the CSL result in transabdominal descent of the testes, whereas in the female, development of the
Zimmermann, S, Steding, G, Emmen, JMA (Judith), Brinkmann, Albert, Nayernia, K, Holstein, AF, Engel, W, Adham, IM   +7 more
openaire   +3 more sources

The structural determinants of insulin-like peptide 3 activity

Frontiers in Endocrinology, 2012
INSL3 is a hormone and/or paracrine factor which is a member of the relaxin peptide family. It has key roles as a fertility regulator in both males and females. The receptor for INSL3 is the leucine rich repeat (LRR) containing G-protein coupled receptor
Ross AD Bathgate, Ross AD Bathgate, Soude eZhang, Richard A Hughes, Johan eRosengren, John D Wade   +5 more
doaj   +1 more source

Associations between insulin-like factor 3, scrotal circumference and semen characteristics in young Norwegian Red bulls

Animal, 2023
With the integration of genomic selection in the cattle artificial insemination (AI) industry, bulls are selected for their semen production capacity and fertility at a younger age than previously.
Joanna Bremer, Bjørg Heringstad, Jane M. Morrell, Elisabeth Kommisrud   +3 more
doaj   +1 more source

INSL3/LGR8 role in testicular descent and cryptorchidism

Reproductive BioMedicine Online, 2005
Cryptorchidism, generally referred to a failure of testicular descent into the scrotum, is the most frequent (up to 3-4% at birth) congenital anomaly in newborn boys. Cryptorchidism is closely associated with impaired fertility, and represents an established risk factor for testicular cancer. Like other genital defects, cryptorchidism is believed to be
N V, Bogatcheva, A I, Agoulnik
openaire   +2 more sources