Results 51 to 60 of about 2,190 (162)

FEAT enhances INSL3 expression in testicular Leydig cells [PDF]

Genes to Cells, 2018
AbstractFEAT, the protein encoded by methyltransferase‐like 13 (METTL13), is aberrantly upregulated in most human cancers and potently drives tumorigenesis in vivo; however, its role in normal tissues remains elusive. Immunoblotting has displayed weak FEAT expression in normal human tissues, including the testis.
Yan Li, Kyosuke Kobayashi, Kosho Murayama, Kohichi Kawahara, Yuichi Shima, Akira Suzuki, Kenzaburo Tani, Atsushi Takahashi   +7 more
openaire   +2 more sources

Clinicopathological and molecular characterization of HPV‐associated cervical poorly cohesive carcinoma: a rare aggressive entity

The Journal of Pathology: Clinical Research, Volume 12, Issue 4, July 2026.
Abstract Primary signet‐ring cell carcinoma and poorly differentiated adenocarcinoma with poorly cohesive morphology in the cervix are rare conditions, and their clinicopathological features remain poorly described. This study defines primary cervical poorly differentiated adenocarcinomas meeting the diagnostic criteria for poorly cohesive carcinoma as
Wei Liu, Xiao‐jiang Wang, Yan‐mei Cui, Jing‐cheng Liu, Jiajie Zhang, Li‐bin Zhang, Xi Lei, Xiuqin Weng, Wucheng Shen, Wen‐xiu Miao, Jun‐cheng Ye, Tong‐mei He, Qin Xu, Yi Shi, Dan Hu   +14 more
wiley   +1 more source

Expression of Insl3 Protein in Adult Danio rerio

International Journal of Molecular Sciences
Insulin-like peptide 3 (INSL3) is a biomarker for Leydig cells in the testes of vertebrates, and it is principally involved in spermatogenesis through specific binding with the RXFP2 receptor. This study reports the insl3 gene transcript and the Insl3 prepropeptide expression in both non-reproductive and reproductive tissues of Danio rerio.
Donizetti, Aldo, Calicchio, Mauro, Romano, Maria Zelinda, Rosati, Luigi, Turco, Manuela, Carrese, Anna Maria, del Gaudio, Rosanna, Ferrandino, Ida, Aniello, Francesco   +8 more
openaire   +3 more sources

The INSL3-LGR8/GREAT Ligand-Receptor Pair in Human Cryptorchidism [PDF]

The Journal of Clinical Endocrinology & Metabolism, 2003
Testicular descent is a complex multistep embryonic process requiring the interaction between anatomical and hormonal factors. Failure in any of these steps results in cryptorchidism, the most frequent congenital anomaly of the urogenital tract in human males.
FERLIN, ALBERTO, SIMONATO M, BARTOLONI L, RIZZO G, BETTELLA A, DOTTORINI T, DALLAPICCOLA B, FORESTA, CARLO   +7 more
openaire   +2 more sources

Theca Cell INSL3 and Steroids Together Orchestrate the Growing Bovine Antral Follicle

Frontiers in Physiology, 2017
Insulin-like peptide 3 (INSL3) and its specific receptor RXFP2 are both expressed by theca interna cells of the growing antral follicle where they form an essential regulatory element in the production of the steroid precursor androstenedione.
Yanzhenzi Dai, Richard Ivell, Richard Ivell, Richard Ivell, Ravinder Anand-Ivell   +4 more
doaj   +1 more source

Update of the risk assessment on dioxins and dioxin‐like PCBs in feed and food

EFSA Journal, Volume 24, Issue 6, June 2026.
Abstract The European Commission asked EFSA to update its 2018 risk assessment on polychlorinated dibenzo‐p‐dioxins and dibenzofurans (PCDD/Fs) and dioxin‐like polychlorinated biphenyls (DL‐PCBs) in feed and food, based on the 2022 WHO Toxic Equivalency Factors (WHO2022‐TEFs).
EFSA Panel on Contaminants in the Food Chain (CONTAM Panel), Helle Katrine Knutsen, Agneta Åkesson, Vasileios Bampidis, Margherita Bignami, Laurent Bodin, James Kevin Chipman, Gisela Degen, Antonio Hernández‐Jerez, Tim Hofer, Christer Hogstrand, Stefano Landi, Jean‐Charles Leblanc, Kyriaki Machera, Evangelia Ntzani, Isabelle P. Oswald, Guido Rychen, Salomon Sand, Katharina Vejdovszky, Barbara Viviani, Jesús del Mazo, Andy Hart, Dieter Schrenk, José Cortiñas Abrahantes, Luisa Ramos Bordajandi, Francesca Riolo, Tuuli Tauriainen, Ron Hoogenboom   +27 more
wiley   +1 more source

Diethylstilbestrol Action on Leydig Cell Function and Testicular Descent

CHIMIA, 2008
Exposure to environmental chemicals may adversely affect the endocrine system and male sexual development. Testicular descent is regulated hormonally by Leydig-cell derived testosterone and Insulin-like factor 3 (Insl3).
Christopher R. Cederroth, Serge Nef
doaj   +1 more source

Modified cytoskeletal and extracellular matrix composition in the canine testis after long‐acting gonadotropin‐releasing hormone agonist deslorelin treatment

Andrology, Volume 14, Issue 3, Page 718-735, March 2026.
Abstract Background Long‐acting gonadotropin‐releasing hormone (GnRH) agonists are commonly used for fertility control in male dogs. Their effect on testicular histomorphology has not been clarified. Objectives To elucidate the mechanisms underlying androgen withdrawal in response to long‐acting GnRH agonist deslorelin 4.7 mg treatment on testicular ...
Aykut Gram, Murat Abay, Duygu Yaman Gram, Narin Liman, Linda Müller, Orsolya Balogh   +5 more
wiley   +1 more source

Effects of prenatal Leydig cell function on the ratio of the second to fourth digit lengths in school-aged children. [PDF]

PLoS ONE, 2015
Prenatal sex hormones can induce abnormalities in the reproductive system and adversely impact on genital development. We investigated whether sex hormones in cord blood influenced the ratio of the second to fourth digit lengths (2D/4D) in school-aged ...
Takahiko Mitsui, Atsuko Araki, Ayako Imai, Sakiko Sato, Chihiro Miyashita, Sachiko Ito, Seiko Sasaki, Takeya Kitta, Kimihiko Moriya, Kazutoshi Cho, Keita Morioka, Reiko Kishi, Katsuya Nonomura   +12 more
doaj   +1 more source

The Intersection of m6A Methylation and Immune Response in PCOS: A Bioinformatics Perspective

Immunity, Inflammation and Disease, Volume 14, Issue 2, February 2026.
N6‐methyladenosine RNA methylation regulators are intricately linked with the development of polycystic ovary syndrome (PCOS) and may influence immune cell infiltration in affected individuals. This study enhances our understanding of the molecular interactions in PCOS and suggests potential biomarkers for diagnosis and targets for therapeutic ...
Wenting Xu, Lingli Shi, Aifang Lu, Lijuan Cui, Haiqing Qian, Jiahui Wang, Mengyu Tang, Lili Zhu, Lihong Wang   +8 more
wiley   +1 more source