Results 61 to 70 of about 2,190 (162)

Relaxin‐like bioactivity of ovine Insulin 3 (INSL3) analogues [PDF]

European Journal of Biochemistry, 2002
Relaxin is an insulin‐like peptide consisting of two separate chains (A and B) joined by two inter‐ and one intrachain disulfide bonds. Binding to its receptor requires an Arg–X–X–X–Arg–X–X–Ile motif in the B‐chain. A related member of the insulin superfamily, INSL3, has a tertiary structure that is predicted to be similar to relaxin. It also possesses
Antonia A, Claasz, Courtney P, Bond, Ross A, Bathgate, Laszlo, Otvos, Nicola F, Dawson, Roger J, Summers, Geoffrey W, Tregear, John D, Wade   +7 more
openaire   +2 more sources

Anti-Müllerian Hormone and Insulin-Like Peptide 3 Levels in Adolescent Polycystic Ovary Syndrome: Correlation with Androgen Levels and Ultrasonographic Features

Forbes Tıp Dergisi
Objective: Polycystic ovary syndrome (PCOS) is a common endocrine disorder characterized by chronic anovulation and hyperandrogenism. In adolescents, the diagnosis is challenging because of overlap with physiological pubertal changes.
Ayça KÖMÜRLÜOĞLU TAN, E. Nazlı GÖNÇ, Z. Alev ÖZÖN, Nurgün KANDEMİR, H. Nursun ÖZCAN, Ayfer ALİKAŞİFOĞLU   +5 more
doaj   +1 more source

Progress in RNA‐Targeted Therapeutics for Human Diseases

MedComm, Volume 7, Issue 2, February 2026.
RNA‐targeted therapies are revolutionizing molecular medicine by transitioning from a “protein‐centric” focus to an “RNA‐regulatory network” approach. Leveraging RNA's diverse roles in gene regulation, signaling, and epigenetic modifications, advanced platforms such as ASOs, siRNA, miRNA, mRNA, aptamers, shRNA, and CRISPR/Cas systems are enabling ...
Wangzheqi Zhang, Aimin Jiang, Bin‐Kui Jia, Yuming Jin, Yinghu Chen, Zhaoyu Li, Yan Liao, Haoling Zhang, Zhiheng Lin, Xiao Fang, Linhui Wang   +10 more
wiley   +1 more source

Associations Between 40‐Year Trajectories of BMI and Proteomic and Epigenetic Aging Clocks: Deciphering Nonlinearity and Interactions

Aging Cell, Volume 25, Issue 2, February 2026.
In twins followed up over 40 years across adulthood, we examined associations between long‐term body mass index trajectories and downstream acceleration in proteomic and epigenetic aging. We further examined whether these associations showed statistical evidence for nonlinear patterns.
Gabin Drouard, M. Austin Argentieri, Aino Heikkinen, Miina Ollikainen, Jaakko Kaprio   +4 more
wiley   +1 more source

Ex Vivo Spatiotemporal Characterization of Spermatogenesis in Mouse Testicular Organoids

Advanced Science, Volume 13, Issue 4, 19 January 2026.
To date, in vitro spermatogenesis remains a challenge in reproductive medicine. In this study, Sun et al. developed a promising in vitro strategy to generate testicular organoids that enable germ cells from newborn mice to enter meiosis, complete chromosome recombination and synapsis, and develop into haploid spermatids.
Jiachen Sun, Lifa Zhu, Yutong Li, Jinyan Tang, Tao Zhang, Hengjia Zhang, Wanchu Wang, Lufan Li, Shuhui Bian, Xin Wu   +9 more
wiley   +1 more source

Therian origin of INSL3/RXFP2-driven testicular descent in mammals

Frontiers in Cell and Developmental Biology
Introduction: During early development in most male mammals the testes move from a position near the kidneys through the abdomen to eventually reside in the scrotum.
Brandon R. Menzies, Gerard A. Tarulli, Stephen R. Frankenberg, Andrew J. Pask   +3 more
doaj   +1 more source

Human amniotic fluid-based exposure levels of phthalates and bisphenol A mixture reduce INSL3/RXFP2 signaling

Environment International, 2020
Background: The presence of chemical pollutants in the environment can affect human health. Epidemiological and in vivo experimental studies reveal reprotoxic effects (undescended testis) of phthalates (diethylhexyl phthalate (DEHP), dibutyl phthalate ...
Valentine Suteau, Claire Briet, Maÿlis Lebeault, Louis Gourdin, Daniel Henrion, Patrice Rodien, Mathilde Munier   +6 more
doaj   +1 more source

Decoding the Follicular Fluid Microenvironment: Integrative Biomarkers and Multiomics Signatures to Predict IVF Outcomes

Reproductive Medicine and Biology, Volume 25, Issue 1, January/December 2026.
ABSTRACT Background With the increase in the number of patients with infertility, the number of patients requiring in vitro fertilization and embryo transfer (IVF‐ET) is also increasing. No established method exists for predicting pregnancy rates under IVF‐ET, and the urgent development of pregnancy predictive biomarkers is required.
Ayako Muraoka, Hiroaki Kajiyama
wiley   +1 more source

Night work during pregnancy and risk of cryptorchidism among male offspring: A Danish nationwide register‐based cohort study

Andrology, Volume 14, Issue 1, Page 140-148, January 2026.
Abstract Aim The aim was to investigate the association between night work during pregnancy and the risk of having a male offspring with cryptorchidism. Furthermore, we explored if the risk of cryptorchidism increased based on trimester‐specific night work (gestational weeks 1–12 and 13–22) by sensitivity analyses.
Charlotte Bertelsen, Luise Mølenberg Begtrup, Paula E. C. Hammer, Jens Peter Ellekilde Bonde, Anne Helene Garde, Ina Olmer Specht, Johnni Hansen, Esben Flachs Meulengracht, Camilla Sandal Sejbæk   +8 more
wiley   +1 more source

Amniotic Fluid INSL3 Measured During the Critical Time Window in Human Pregnancy Relates to Cryptorchidism, Hypospadias, and Phthalate Load: A Large Case–Control Study

Frontiers in Physiology, 2018
The period of the first to second trimester transition in human pregnancy represents a sensitive window for fetal organogenesis, particularly in regard to the development of the male reproductive system.
Ravinder Anand-Ivell, Arieh Cohen, Bent Nørgaard-Pedersen, Bo A. G. Jönsson, Jens-Peter Bonde, David M. Hougaard, Christian H. Lindh, Gunnar Toft, Morten S. Lindhard, Richard Ivell, Richard Ivell   +10 more
doaj   +1 more source