Results 61 to 70 of about 4,038 (203)

Insulin 3-like hormone and its role in epididymo-testicular descent

International Brazilian Journal of Urology, 2007
PURPOSE: The role of insulin 3-like (Insl3) hormone signaling in the testicular descent process has been demonstrated. The purpose of the present study was to evaluate epididymal development in Insl3-deficient mice.
Faruk Hadziselimovic, Ibrahim Adham
doaj   +1 more source

Cryptorchidism: Novel genetic insights into CCDC149 mutations

Andrology, EarlyView.
Abstract Background Cryptorchidism, characterized by the failure of one or both testes to descend into the scrotum, is a common congenital condition that can lead to infertility and increased risk of testicular cancer. CCDC149, a coiled‐coil domain‐containing protein, has been implicated in various developmental processes, but its role in the male ...
Shengrong Du, Shan Xu, Lei Yang, Yan Ye, Yuhan Wu, Ziyun Xiao, Xiuqing Dong, Wenliang Yao, Hua Li   +8 more
wiley   +1 more source

FEAT enhances INSL3 expression in testicular Leydig cells [PDF]

Genes to Cells, 2018
AbstractFEAT, the protein encoded by methyltransferase‐like 13 (METTL13), is aberrantly upregulated in most human cancers and potently drives tumorigenesis in vivo; however, its role in normal tissues remains elusive. Immunoblotting has displayed weak FEAT expression in normal human tissues, including the testis.
Yan Li, Kyosuke Kobayashi, Kosho Murayama, Kohichi Kawahara, Yuichi Shima, Akira Suzuki, Kenzaburo Tani, Atsushi Takahashi   +7 more
openaire   +2 more sources

Maternal, childhood and adolescent influences on Leydig cell functional capacity and circulating INSL3 concentration in young adults: Importance of childhood infections and body mass index

Andrology, EarlyView.
Abstract Background The constitutive Leydig cell hormone insulin‐like peptide 3 (INSL3) is considered a good estimate of the adult Leydig cell functional capacity and appears to remain relatively consistent throughout adult male life, only gradually declining into old age.
Richard Ivell, Bilal Tulumcu, Waleed Alhujaili, Ravinder Anand‐Ivell   +3 more
wiley   +1 more source

Insulin-like peptide 3 (INSL3) as an indicator of leydig cell insufficiency (LCI) in Middle-aged and older men with hypogonadism: reference range and threshold

The Aging Male
Insulin-like peptide 3 (INSL3) is a circulating biomarker for Leydig cell functional capacity in men, also indicating Leydig Cell Insufficiency (LCI) and potential primary hypogonadism.
Ravinder Anand-Ivell, Kee Heng, Leen Antonio, Gyorgy Bartfai, Felipe F. Casanueva, Mario Maggi, Terence W. O’Neill, Margus Punab, Giulia Rastrelli, Jolanta Slowikowska-Hilczer, Jos Tournoy, Dirk Vanderschueren, Frederick CW. Wu, Ilpo T. Huhtaniemi, Richard Ivell   +14 more
doaj   +1 more source

New Insights into the Role of INSL-3 in the Development of Cryptorchidism

Children, 2023
Cryptorchidism, defined as the failure of at least one or both testicles to descend into the scrotal pouches, is the most frequent (1.6–9% at birth, 1/20 males at birth) congenital anomaly encountered in newborn males, resulting in one of the most ...
Alma-Raluca Lăptoiu, Elena-Lia Spoială, Gabriela Dumitrita Stanciu, Elena Hanganu, Vasile Valeriu Lupu, Carmen-Iulia Ciongradi, Cristina Gavrilovici   +6 more
doaj   +1 more source

Transcriptome analysis of the adult human Klinefelter testis and cellularity-matched controls reveals disturbed differentiation of Sertoli- and Leydig cells article [PDF]

, 2018
The most common human sex chromosomal disorder is Klinefelter syndrome (KS; 47,XXY). Adult patients with KS display a diverse phenotype but are nearly always infertile, due to testicular degeneration at puberty.
Aksglaede, Lise, Almstrup, Kristian, Belling, Kirstine G., Brunak, Søren, Dalgaard, Marlene Danner, Jensen, Jacob Malte, Juul, Anders, Nielsen, John Erik, Rajpert-De Meyts, Ewa, Schierup, Mikkel Heide, Skakkebæk, Niels Erik, Winge, Sofia Boeg   +11 more
core   +2 more sources

Assessing a Model for a Complex Systemic Disorder—The Value of Male Mice With a Supernumerary X Chromosome for Klinefelter Syndrome Research

Andrology, EarlyView.
ABSTRACT Introduction Direct experimental investigation of Klinefelter syndrome (KS) in patients is limited because the syndrome manifests heterogeneously and affects multiple organ systems. Studying KS therefore requires a model that captures this complexity as accurately as possible while still permitting controlled experimental manipulation ...
Fariba Saadati, Joachim Wistuba
wiley   +1 more source

Candidate gene markers for sperm quality and fertility in bulls [PDF]

, 2013
Fertility is one of the primary traits of reproduction in bulls. Decrease in fertility is a multifactorial condition and is verydifficult to diagnose. Among various causes genetic abnormality holds a major share.
Gross, Howard, Jones, Li-hong, Seidah, Wallis, Winaya   +6 more
core   +1 more source

Modified cytoskeletal and extracellular matrix composition in the canine testis after long‐acting gonadotropin‐releasing hormone agonist deslorelin treatment

Andrology, Volume 14, Issue 3, Page 718-735, March 2026.
Abstract Background Long‐acting gonadotropin‐releasing hormone (GnRH) agonists are commonly used for fertility control in male dogs. Their effect on testicular histomorphology has not been clarified. Objectives To elucidate the mechanisms underlying androgen withdrawal in response to long‐acting GnRH agonist deslorelin 4.7 mg treatment on testicular ...
Aykut Gram, Murat Abay, Duygu Yaman Gram, Narin Liman, Linda Müller, Orsolya Balogh   +5 more
wiley   +1 more source