Results 41 to 50 of about 4,038 (203)

Seasonal Expression of INSL3 and Lgr8/Insl3 Receptor Transcripts Indicates Variable Differentiation of Leydig Cells in the Roe Deer Testis [PDF]

Biology of Reproduction, 2004
Roe deer are seasonal breeders and show cyclic variation in testicular volume and cellular differentiation within the tubular and interstitial testis compartment. We have employed the roe deer as a model to elucidate the expression of the postpubertal Leydig cell marker INSL3 during seasonal changes in Leydig cell differentiation.
Sabine, Hombach-Klonisch, Jennifer, Schön, Astrid, Kehlen, Steffen, Blottner, Thomas, Klonisch   +4 more
openaire   +2 more sources

Regulation of the reproductive cycle and early pregnancy by relaxin family peptides [PDF]

, 2014
The relaxin family of peptide hormones are structurally closely related to one another sharing a heterodimeric A–B structure, like that of insulin. They may also be active as unprocessed B–C–A pro-forms.
Adham, Amory, Anand-Ivell, Anand-Ivell, Anand-Ivell, Anand-Ivell, Anumba, Arroyo, Balvers, Bamberger, Bartsch, Bartsch, Bathgate, Bathgate, Bathgate, Bell, Blankenship, Bogatcheva, Braun, Brännström, Burnicka-Turek, Burnicka-Turek, Büllesbach, Conrad, Einspanier, Einspanier, Ferlin, Ferlin, Feugang, Feugang, Gambineri, Gellersen, Ghattas, Glister, Goldsmith, Granot, Guo, Halls, Halls, Hanna, Hansell, Havelock, Hayes, Heng, Hossain, Hsu, Hughes, Hwang, Irving-Rodgers, Ivell, Ivell, Ivell, Ivell, Ivell, Ivell, Jauniaux, Johnson, Kamat, Kawamura, Kim, Klonisch, Laurent, Lok, Luu, MacLennan, Maseelall, McGowan, McGuane, McMillen, Millar, Minagawa, Mita, Monk, Nef, Nguyen, Ohleth, Parry, Piccinni, Piccinni, Pusch, Ramathal, Ravinder Anand-Ivell, Richard Ivell, Rogers, Satchell, Segal, Sherwood, Shirota, Shirota, Silvertown, Siqin, Smith, Spanel-Borowski, Stewart, Stewart, Tang, Unemori, Unemori, Van Hiel, Vandevoort, Wathes, Wilson, Zimmermann   +102 more
core   +1 more source

Role of INSL3 and LGR8 in cryptorchidism and testicular functions

Reproductive BioMedicine Online, 2004
Cryptorchidism is the most frequent congenital anomaly of the urogenital tract in human males. INSL3 and LGR8/GREAT proteins seem to act as ligand and receptor respectively, and to have a role in gubernaculum development involved in testicular descent.
FORESTA, CARLO, FERLIN, ALBERTO
openaire   +5 more sources

Comments on Li et al. Effects of in Utero Exposure to Dicyclohexyl Phthalate on Rat Fetal Leydig Cells. Int. J. Environ. Res. Public Health 2016, 13, 246 [PDF]

, 2016
Profiling the expression levels of genes or proteins in tissues comprising two or more cell types is commonplace in biological sciences. Such analyses present particular challenges, however, for example a potential shift in cellular composition, or ...
Svingen, Terje
core   +2 more sources

The Overexpression of the Insl3 in Female Mice Causes Descent of the Ovaries [PDF]

Molecular Endocrinology, 2002
Testicular descent in mice is dependent upon proper outgrowth of the gubernaculum primordia under the influence of the insulin-like 3 gene product (Insl3). Deletion of this gene prevents gubernaculum growth and causes bilateral cryptorchidism. In vitro experiments have led to the suggestion that Insl3 and androgens together induce outgrowth of the ...
Adham, Ibrahim M., Steding, G., Thamm, T., Bullesbach, E. E., Schwabe, C., Paprotta, I., Engel, Wolfgang   +6 more
openaire   +3 more sources

Spreading the clinical window for diagnosing fetal-onset hypogonadism in boys [PDF]

, 2014
In early fetal development, the testis secretes – independent of pituitary gonadotropins – androgens and anti-Müllerian hormone (AMH) that are essential for male sex differentiation. In the second half of fetal life, the hypothalamic–pituitary axis gains
Ambao, Veronica Ana, Ballerini, Maria Gabriela, Bedecarras, Patricia Gladys, Bergadá, Ignacio, Braslavsky, Debora Giselle, Campo, Stella Maris, Gottlieb, Silvia Elisa, Grinspon, Romina, Loreti, Rosana Nazareth, Rey, Rodolfo Alberto, Ropelato, Maria Gabriela, Schteingart, Helena Fedora, Valeri, Clara   +12 more
core   +2 more sources

Insulin-like peptide 3 (INSL3) in congenital hypogonadotrophic hypogonadism (CHH) in boys with delayed puberty and adult men

Frontiers in Endocrinology, 2022
BackgroundDelayed puberty in males is almost invariably associated with constitutional delay of growth and puberty (CDGP) or congenital hypogonadotrophic hypogonadism (CHH).
Ali Abbara, Ali Abbara, Kanyada Koysombat, Maria Phylactou, Maria Phylactou, Pei Chia Eng, Pei Chia Eng, Sophie Clarke, Sophie Clarke, Alexander N. Comninos, Alexander N. Comninos, Lisa Yang, Lisa Yang, Chioma Izzi-Engbeaya, Chioma Izzi-Engbeaya, Simon Hanassab, Simon Hanassab, Neil Smith, Channa N. Jayasena, Channa N. Jayasena, Cheng Xu, Cheng Xu, Richard Quinton, Richard Quinton, Nelly Pitteloud, Nelly Pitteloud, Gerhard Binder, Ravinder Anand-Ivell, Richard Ivell, Waljit S. Dhillo, Waljit S. Dhillo   +30 more
doaj   +1 more source

Pivotal role of the muscle-contraction pathway in cryptorchidism and evidence for genomic connections with cardiomyopathy pathways in RASopathies [PDF]

, 2013
BACKGROUND: Cryptorchidism is the most frequent congenital disorder in male children; however the genetic causes of cryptorchidism remain poorly investigated.
Carlo V Cannistraci, Jernej Ogorevc, Minja Zorc, Peter Dovc, Tanja Kunej, Timothy Ravasi   +5 more
core   +1 more source

Genetic analysis of the INSL3 gene in patients with maldescent of the testis [PDF]

European Journal of Endocrinology, 2001
OBJECTIVE: Testicular maldescent is important because it is a common congenital disorder that is associated with an increased risk of infertility and testicular cancer. Murine studies indicate that testicular maldescent can result from disruption of insulin-like factor 3 (INSL3) activity and that it may be more severe when there is concurrent ...
H N, Lim, E, Raipert-de Meyts, N E, Skakkebaek, J R, Hawkins, I A, Hughes   +4 more
openaire   +2 more sources

Origin of INSL3-mediated testicular descent in therian mammals [PDF]

Genome Research, 2008
Testicular descent is a unique physiological adaptation found in therian mammals allowing optimal spermatogenesis below core body temperature. Recent studies show that INSL3, produced by Leydig cells, and its receptor LGR8 (RXFP2) are essential for mediating the transabdominal phase of testicular descent during early development ...
Park, Jae-Il, Semyonov, Jenia, Chang, Chia Lin, Yi, Wei, Warren, Wesley, Hsu, Sheau Yu Teddy   +5 more
openaire   +3 more sources