Results 41 to 50 of about 2,190 (162)

The Overexpression of theInsl3in Female Mice Causes Descent of the Ovaries [PDF]

Molecular Endocrinology, 2002
Testicular descent in mice is dependent upon proper outgrowth of the gubernaculum primordia under the influence of the insulin-like 3 gene product (Insl3). Deletion of this gene prevents gubernaculum growth and causes bilateral cryptorchidism. In vitro experiments have led to the suggestion that Insl3 and androgens together induce outgrowth of the ...
Adham, Ibrahim M., Steding, G., Thamm, T., Bullesbach, E. E., Schwabe, C., Paprotta, I., Engel, Wolfgang   +6 more
openaire   +3 more sources

Assessing a Model for a Complex Systemic Disorder—The Value of Male Mice With a Supernumerary X Chromosome for Klinefelter Syndrome Research

Andrology, EarlyView.
ABSTRACT Introduction Direct experimental investigation of Klinefelter syndrome (KS) in patients is limited because the syndrome manifests heterogeneously and affects multiple organ systems. Studying KS therefore requires a model that captures this complexity as accurately as possible while still permitting controlled experimental manipulation ...
Fariba Saadati, Joachim Wistuba
wiley   +1 more source

Serum INSL3 measured by LC-MS/MS in pubertal girls and in girls with precocious puberty during GnRH agonist treatment

Frontiers in Endocrinology
IntroductionThe peptide hormone Insulin-like Factor 3 (INSL3) is a biomarker of testicular Leydig cells in the male but is also expressed by the theca cells of the ovaries. With the advent of sensitive assays INSL3 can be quantified in female circulation,
Jakob Albrethsen, Jakob Albrethsen, Casper P. Hagen, Casper P. Hagen, Anders Juul, Anders Juul, Anders Juul   +6 more
doaj   +1 more source

Insulin 3-like hormone and its role in epididymo-testicular descent

International Brazilian Journal of Urology, 2007
PURPOSE: The role of insulin 3-like (Insl3) hormone signaling in the testicular descent process has been demonstrated. The purpose of the present study was to evaluate epididymal development in Insl3-deficient mice.
Faruk Hadziselimovic, Ibrahim Adham
doaj   +1 more source

Bone Health and Aging in Klinefelter Syndrome

Andrology, EarlyView.
ABSTRACT Klinefelter syndrome (KS) is typically diagnosed in young adults, but advances in prenatal testing have led to its recognition at a much earlier age. Conversely, diagnosis in late adulthood remains uncommon, but still occurs. Independently from the age at diagnosis, KS individuals now receive more accurate and tailored care management than in ...
Filippo Vignali, Daniele Renda Livraghi, Francesco Costantino, Sara De Vincentis, Vincenzo Rochira   +4 more
wiley   +1 more source

Insulin-like peptide 3 (INSL3) as an indicator of leydig cell insufficiency (LCI) in Middle-aged and older men with hypogonadism: reference range and threshold

The Aging Male
Insulin-like peptide 3 (INSL3) is a circulating biomarker for Leydig cell functional capacity in men, also indicating Leydig Cell Insufficiency (LCI) and potential primary hypogonadism.
Ravinder Anand-Ivell, Kee Heng, Leen Antonio, Gyorgy Bartfai, Felipe F. Casanueva, Mario Maggi, Terence W. O’Neill, Margus Punab, Giulia Rastrelli, Jolanta Slowikowska-Hilczer, Jos Tournoy, Dirk Vanderschueren, Frederick CW. Wu, Ilpo T. Huhtaniemi, Richard Ivell   +14 more
doaj   +1 more source

Testicular Biopsies in Adolescent and Adult Andrological Patients: The EAA Clinical Guidelines

Andrology, Volume 14, Issue 7, Page 1906-1928, October 2026.
ABSTRACT Background Histological evaluation of testicular tissue is central to the assessment of infertile men, particularly those at an increased risk of testicular germ cell tumors (TGCT). Traditionally, testicular biopsies have been used primarily for diagnostic purposes, such as the detection of germ cell neoplasia in situ (GCNIS). With advances in
Lise Aksglaede, George Kanakis, Ewa Rajpert‐De Meyts, Davor Jezek, Ferran Algaba, Gert Dohle, Jolanta Slowikowska‐Hilczer, Sabine Kliesch, Hermann M. Behre, Csilla Krausz, Dimitrios G. Goulis, Niels Jørgensen   +11 more
wiley   +1 more source

Relaxin‐2: Shaping the Proteomic Landscape of Skeletal Muscle Physiology, Glucose Trafficking, and Mitochondrial Function in Rat

The FASEB Journal, Volume 40, Issue 18, 30 September 2026.
Cardioprotective hormone relaxin‐2 showed relevant effects on rat skeletal muscle by altering proteins linked to muscle function, regeneration, differentiation, mitochondrial function, glucose metabolism, and structural integrity and organization. Specifically, relaxin‐2 reduced the expression of 95 proteins, increased 32, and elicited unique proteins ...
Xocas Vázquez‐Abuín, Lucía Gómez‐Cibeira, Javier García‐Seara, Pablo de la Fuente‐López, Carlos Minguito‐Carazo, Susana B. Bravo, Manuel Otero‐Santiago, Oreste Gualillo, José Ramón González‐Juanatey, Francisca Lago, Sandra Feijóo‐Bandín, Alana Aragón‐Herrera   +11 more
wiley   +1 more source

New Insights into the Role of INSL-3 in the Development of Cryptorchidism

Children, 2023
Cryptorchidism, defined as the failure of at least one or both testicles to descend into the scrotal pouches, is the most frequent (1.6–9% at birth, 1/20 males at birth) congenital anomaly encountered in newborn males, resulting in one of the most ...
Alma-Raluca Lăptoiu, Elena-Lia Spoială, Gabriela Dumitrita Stanciu, Elena Hanganu, Vasile Valeriu Lupu, Carmen-Iulia Ciongradi, Cristina Gavrilovici   +6 more
doaj   +1 more source

Proteomic Profiling Using a Proximity Extension Assay Panel on Serum Samples Stored at −25°C Over Several Decades

PROTEOMICS, Volume 26, Issue 9, Page 106-112, September 2026.
ABSTRACT The advent of proteomics assays that provide accurate levels of thousands of proteins from relatively small sample volumes opens possibilities for biomarker research in biobanks with valuable samples. In this study, we leverage the applicability of the Olink proximity extension assay to profile serum samples of the Janus Serum Bank, which have
Steffan Daniel Bos, Sigrún Helga Lund, Renée Turzanski Fortner, Eivind Hovig, Hilde Langseth   +4 more
wiley   +1 more source