Results 21 to 30 of about 4,038 (203)
INSL3 in the ruminant: a powerful indicator of gender- and genetic-specific feto-maternal dialogue. [PDF]
PLoS ONE, 2011 The hormone Insulin-like peptide 3 (INSL3) is a major secretory product of the Leydig cells from both fetal and adult testes. Consequently, it is a major gender-specific circulating hormone in the male fetus, where it is responsible for the first phase ...
Ravinder Anand-Ivell +7 more
doaj +1 more source
The Journal of Reproduction and Development, 2022 Insulin-like peptide 3 (INSL3) and sex steroids were measured in bovine dominant follicles and corpora lutea during the estrus cycle and in follicular cysts.
Hewage Dilhan Anuradha WIMALARATHNE +2 more
doaj +1 more source
Frontiers in Endocrinology, 2020 The structure of the testicular peptide hormone insulin-like factor 3 (INSL3) has been the subject of discussion for more than a decade. Some studies support that the central C-domain of INSL3 is proteolytically removed and that INSL3 is secreted by the ...
Jakob Albrethsen +5 more
doaj +1 more source
Revealing the endocrine landscape of INSL3/RXFP2 signaling in hamster. [PDF]
PLoS OneIn mammals, insulin-like peptide 3 (INSL3) and its cognate receptor (RXFP2) are reported to be essential regulators of male reproductive physiology. It is also believed that INSL3/RXFP2 signaling has a role in female ovarian function and follicle development, although its exact mechanisms and functions are still being studied.
Ruiz A, Ramos L.
europepmc +4 more sources
Cellular & Molecular Biology Letters, 2023 Background Testicular hypoplasia can affect the sexual and reproductive ability in adulthood, and even increase the risk of cancer. Abnormal development of the gubernaculum is one of the important factors of testicular hypoplasia.
Shouxing Duan +12 more
doaj +1 more source
Profiling insulin like factor 3 (INSL3) signaling in human osteoblasts. [PDF]
PLoS ONE, 2011 BACKGROUND: Young men with mutations in the gene for the INSL3 receptor (Relaxin family peptide 2, RXFP2) are at risk of reduced bone mass and osteoporosis.
Alberto Ferlin +4 more
doaj +1 more source
Endocrine Connections, 2023 Congenital adrenal hyperplasia (CAH) is a recessive condition t hat affects the adrenal glands. Despite life-long replacement therapy with glucocorticoids and mineralocorticoids, adult patients with CAH often experience impaired gonadal function.
Trine Holm Johannsen +11 more
doaj +1 more source
Phenotype-specific association of the TGFBR3 locus with nonsyndromic cryptorchidism [PDF]
, 2015 PURPOSE: Based on a genome-wide association study of testicular dysgenesis syndrome showing a possible association with TGFBR3, we analyzed data from a larger, phenotypically restricted cryptorchidism population for potential replication of this signal.
Abrams, D +18 more
core +1 more source
Novas perspectivas no diagnóstico do hipogonadismo pediátrico masculino: a importância do AMH como marcador de células de Sertoli [PDF]
, 2011 Sertoli cells are the most active cell population in the testis during infancy and childhood. In these periods of life, hypogonadism can only be evidenced without stimulation tests, if Sertoli cell function is assessed.
Grinspon, Romina, Rey, Rodolfo Alberto
core +2 more sources
A functional link between bone morphogenetic proteins and insulin-like peptide 3 signaling in modulating ovarian androgen production [PDF]
, 2013 Bone morphogenetic proteins (BMP) are firmly implicated as intra-ovarian regulators of follicle development and steroidogenesis. Here we report a microarray analysis showing that treatment of cultured bovine theca cells (TC) with BMP6 significantly (>2 ...
Anand-Ivell +47 more
core +1 more source