Results 21 to 30 of about 2,190 (162)

Reduced serum concentrations of biomarkers reflecting Leydig and Sertoli cell function in male patients with congenital adrenal hyperplasia

Endocrine Connections, 2023
Congenital adrenal hyperplasia (CAH) is a recessive condition t hat affects the adrenal glands. Despite life-long replacement therapy with glucocorticoids and mineralocorticoids, adult patients with CAH often experience impaired gonadal function.
Trine Holm Johannsen, Jakob Albrethsen, Vassos Neocleous, Federico Baronio, Martine Cools, Lise Aksglaede, Niels Jørgensen, Peter Christiansen, Meropi Toumba, Pavlos Fanis, Marie Lindhardt Ljubicic, Anders Juul   +11 more
doaj   +1 more source

Profiling insulin like factor 3 (INSL3) signaling in human osteoblasts. [PDF]

PLoS ONE, 2011
BACKGROUND: Young men with mutations in the gene for the INSL3 receptor (Relaxin family peptide 2, RXFP2) are at risk of reduced bone mass and osteoporosis.
Alberto Ferlin, Lisa Perilli, Lisa Gianesello, Giuseppe Taglialavoro, Carlo Foresta   +4 more
doaj   +1 more source

Protective Role of Testicular Hormone INSL3 From Atrophy and Weakness in Skeletal Muscle

Frontiers in Endocrinology, 2018
Androgens are primarily involved in muscle growth, whilst disease-driven muscle wasting is frequently associated with hypogonadism. The Leydig cells of the testes also produce the peptide-hormone Insulin-like peptide 3 (INSL3).
Alberto Ferlin, Luca De Toni, Alexander I. Agoulnik, Giorgia Lunardon, Andrea Armani, Sergia Bortolanza, Bert Blaauw, Marco Sandri, Marco Sandri, Carlo Foresta   +9 more
doaj   +1 more source

Insulin-Like Peptide 3 (INSL3) Serum Concentration During Human Male Fetal Life

Frontiers in Endocrinology, 2019
Context: Insulin-like peptide 3 (INSL3), a protein hormone produced by Leydig cells, may play a crucial role in testicular descent as male INSL3 knockout mice have bilateral cryptorchidism.
Steven M. Harrison, Nicol Corbin Bush, Yi Wang, Zachary R. Mucher, Armando J. Lorenzo, Gwen M. Grimsby, Bruce J. Schlomer, Erika E. Büllesbach, Linda A. Baker   +8 more
doaj   +1 more source

INSL3 as a Biomarker of Leydig Cell Functionality

Biology of Reproduction, 2013
Insulin-like factor 3 (INSL3) is a small peptide hormone made and secreted uniquely by mature Leydig cells in the testes of all mammals. Importantly, this expression and secretion appears to be constitutive and therefore reflects the differentiation status and number of the Leydig cells present, differing thereby from testosterone, which is acutely and
Ivell, R., Wade, J., Anand Ivell, R.
openaire   +3 more sources

Seasonal Expression of INSL3 and Lgr8/Insl3 Receptor Transcripts Indicates Variable Differentiation of Leydig Cells in the Roe Deer Testis [PDF]

Biology of Reproduction, 2004
Roe deer are seasonal breeders and show cyclic variation in testicular volume and cellular differentiation within the tubular and interstitial testis compartment. We have employed the roe deer as a model to elucidate the expression of the postpubertal Leydig cell marker INSL3 during seasonal changes in Leydig cell differentiation.
Sabine, Hombach-Klonisch, Jennifer, Schön, Astrid, Kehlen, Steffen, Blottner, Thomas, Klonisch   +4 more
openaire   +2 more sources

New JAK3-INSL3 Fusion Transcript—An Oncogenic Event in Cutaneous T-Cell Lymphoma

Cells, 2023
Constitutively activated tyrosine kinase JAK3 is implicated in the pathogenesis of cutaneous T-cell lymphomas (CTCL). The mechanisms of constitutive JAK3 activation are unknown although a JAK3 mutation was reported in a small portion of CTCL patients. In
Loka Reddy Velatooru, Cheng Hui Hu, Pedram Bijani, Xiaohong Wang, Pierr Bojaxhi, Hao Chen, Madeleine Duvic, Xiao Ni   +7 more
doaj   +1 more source

The Male Fetal Biomarker INSL3 Reveals Substantial Hormone Exchange between Fetuses in Early Pig Gestation. [PDF]

PLoS ONE, 2016
The peptide hormone INSL3 is uniquely produced by the fetal testis to promote the transabdominal phase of testicular descent. Because it is fetal sex specific, and is present in only very low amounts in the maternal circulation, INSL3 acts as an ideal ...
Andreas Vernunft, Richard Ivell, Kee Heng, Ravinder Anand-Ivell   +3 more
doaj   +1 more source

Revealing the endocrine landscape of INSL3/RXFP2 signaling in hamster. [PDF]

PLoS One
In mammals, insulin-like peptide 3 (INSL3) and its cognate receptor (RXFP2) are reported to be essential regulators of male reproductive physiology. It is also believed that INSL3/RXFP2 signaling has a role in female ovarian function and follicle development, although its exact mechanisms and functions are still being studied.
Ruiz A, Ramos L.
europepmc   +4 more sources

Genetic analysis of the INSL3 gene in patients with maldescent of the testis [PDF]

European Journal of Endocrinology, 2001
OBJECTIVE: Testicular maldescent is important because it is a common congenital disorder that is associated with an increased risk of infertility and testicular cancer. Murine studies indicate that testicular maldescent can result from disruption of insulin-like factor 3 (INSL3) activity and that it may be more severe when there is concurrent ...
H N, Lim, E, Raipert-de Meyts, N E, Skakkebaek, J R, Hawkins, I A, Hughes   +4 more
openaire   +2 more sources