Results 1 to 10 of about 4,930,458 (259)

Fibroblast Growth Factor 1 Promotes Rat Stem Leydig Cell Development [PDF]

Frontiers in Endocrinology, 2019
Fibroblast growth factor 1 (FGF1) is reported to be expressed in the testis. How FGF1 affects stem Leydig cell development remains unclear. Here, we report the effects of FGF1 on rat stem Leydig cell development in an ethane dimethane sulfonate (EDS ...
Lanlan Chen, Lanlan Chen, Xiaoheng Li, Yiyan Wang, Tiantian Song, Huitao Li, Lubin Xie, Linchao Li, Xianwu Chen, Leikai Ma, Yong Chen, Yao Lv, Xingwang Li, Ren-Shan Ge, Ren-Shan Ge   +14 more
doaj   +2 more sources

When Testosterone Fades: Leydig Cell Aging Shaped by Environmental Toxicants, Metabolic Dysfunction, and Testicular Niche Crosstalk [PDF]

Cells
Declining Leydig cell steroidogenesis contributes to late-onset hypogonadism and to age-associated impairment of male reproductive health. Determinants of dysfunction extend beyond chronological aging.
Aris Kaltsas, Fotios Dimitriadis, Athanasios Zachariou, Sotirios Koukos, Michael Chrisofos, Nikolaos Sofikitis   +5 more
doaj   +2 more sources

Involvement of p38 MAPK in Leydig cell aging and age-related decline in testosterone

Frontiers in Endocrinology, 2023
IntroductionAge-related decline in testosterone is associated with Leydig cell aging with impaired testosterone synthesis in aging. Obesity accelerates the age-related decline in testosterone.
Dandan Luo, Dandan Luo, Xiangyu Qi, Xiaoqin Xu, Xiaoqin Xu, Leilei Yang, Leilei Yang, Chunxiao Yu, Chunxiao Yu, Qingbo Guan, Qingbo Guan   +10 more
doaj   +1 more source

Triadimefon increases fetal Leydig cell proliferation but inhibits its differentiation of male fetuses after gestational exposure

Ecotoxicology and Environmental Safety, 2021
Triadimefon is a broad-spectrum fungicide widely applied in the agriculture. It is believed to be an endocrine disruptor. Whether triadimefon can inhibit the development of fetal Leydig cells and the underlying mechanisms are unknown.
Liben Lin, Qiang Xu, Quanxu Chen, Haiqiong Chen, Yingfen Ying, Zengqiang Li, Song Zhang, Feifei Ma, Yige Yu, Ren-Shan Ge   +9 more
doaj   +1 more source

Fetal Leydig cells in buffalo testis: Light and electron microscopic study

Indian Journal of Animal Sciences, 2020
The present study was conducted on testis of 20 buffalo fetuses ranging from 2.5 cm to 20 cm curved crown rump length (CVRL). The tissues were processed for light and transmission electron microscopic study.
INDERPREET SINGH, NEELAM BANSAL, DEVENDRA PATHAK, VARINDER UPPAL, ANURADHA GUPTA   +4 more
doaj   +1 more source

Role of antioxidant to protect Leydig cells induced by reactive oxygen species: a literature review

Qanun Medika: Jurnal Kedokteran Fakultas Kedokteran Universitas Muhammadiyah Surabaya, 2021
The Leydig cells play crucial role in steroidogenesis and spermatogenesis. Those processes need complex communication in hormonal and testicular to maintain male reproductive function.
Anak Agung Istri Dalem Cinthya Riris, Reny I'tishom, Siti Khaerunnisa   +2 more
doaj   +1 more source

Quantitation of Leydig Cell in Testicular Biopsies of Gossypol Treated rats

The Iraqi Journal of Veterinary Medicine, 2005
Leydig cell density was evaluated quantitatively in bilateral testicular biopsies from twenty male rats of two equal groups Gossypol treated and control.
Muhannad A. A. Al Bayaty
doaj   +1 more source

TRPV1 activation induces cell death of TM3 mouse Leydig cells

Journal of Animal Reproduction and Biotechnology, 2021
The role of transient receptor potential vanilloid receptor-1 (TRPV1) has been primarily investigated in pain sensory neurons. Relatively, little research has been performed in testicular cells.
Eun-Jin Kim, Long Cao Dang, Marie Merci Nyiramana, Adrian S. Siregar, Min-Seok Woo, Chang-Woon Kim, Dawon Kang   +6 more
doaj   +1 more source

Central Precocious Puberty Following Treatment of Precocious Pseudo-Puberty Caused by Leydig Cell Tumor: A Pediatric Case and Literature Review

Clinical Pediatric Hematology-Oncology, 2022
Leydig cell tumors can cause precocious puberty in prepubertal males. Radical orchiectomy is the standard therapy for Leydig cell tumors, with a good overall prognosis.
Jeong Ho Ahn, Ji Kyoung Park, Soo Jin Jung, Jeong Eun Lee   +3 more
doaj   +1 more source

Silencing of MEG3 attenuated the role of lipopolysaccharides by modulating the miR-93-5p/PTEN pathway in Leydig cells

Reproductive Biology and Endocrinology, 2021
Background Leydig cells reflect the activation of inflammation, decrease of androgen production, inhibition of cell growth and promotion of cell apoptosis under orchitis. Maternally expressed gene 3 (MEG3) exerts a crucial role in various human diseases,
Xu Zhou, Jingliang He, Jinbo Chen, Yu Cui, Zhenyu Ou, Xiongbing Zu, Nenghui Liu   +6 more
doaj   +1 more source