Differentiation of adult-type Leydig cells occurs in gonadotrophin-deficient mice [PDF]
Reproductive Biology and Endocrinology, 2003 During mammalian testis development distinct generations of fetal and adult Leydig cells arise. Luteinising hormone (LH) is required for normal adult Leydig cell function and for the establishment of normal adult Leydig cell number but its role in the ...
Charlton HM +4 more
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Parathyroid Hormone-Related Protein Promotes Rat Stem Leydig Cell Differentiation [PDF]
Frontiers in Physiology, 2017 The regulatory factors for stem Leydig cell development are largely unknown. Herein, we reported that parathyroid hormone-related protein (PTHrP) may be a factor to regulate this process.
Tiantian Song +11 more
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Relationship of transcriptional markers to Leydig cell number in the mouse testis. [PDF]
PLoS ONE, 2019 ObjectivesThe current study aims to identify markers that would reflect the number of Leydig cells present in the testis, to help determine whether labour-intensive methods such as stereology are necessary.
Diane Rebourcet +7 more
doaj +2 more sources
Reproductive Biology and EndocrinologyWith the global population aging at an accelerated pace, testicular aging and its associated male health issues have garnered increasing attention. Testicular aging encompasses both age-related physiological decline and premature or pathological aging ...
Wen-bo Zhu +4 more
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Fetal Leydig cells dedifferentiate and serve as adult Leydig stem cells [PDF]
Development, 2018 ABSTRACT Previous studies have established that fetal Leydig cells (FLCs) and adult Leydig cells (ALCs) show distinct functional characteristics. However, the lineage relationship between FLCs and ALCs has not been clarified yet. Here, we reveal that a subset of FLCs dedifferentiate at fetal stages to give rise to ALCs at the pubertal ...
Yuichi Shima +7 more
openaire +2 more sources
Dexamethasone suppresses the differentiation of stem Leydig cells in rats in vitro
BMC Pharmacology and Toxicology, 2019 Background It is an established fact that excess of glucocorticoids could cause the harmful effects, such as suppression on the male reproduction. Although glucocorticoids pharmacologically inhibit the Leydig cell function, their roles in Leydig cell ...
Jingwei Zhang +8 more
doaj +1 more source
Vitamin A Promotes Leydig Cell Differentiation via Alcohol Dehydrogenase 1
Frontiers in Endocrinology, 2018 Vitamin A (retinol) is important for multiple functions in mammals. In testis, the role of vitamin A in the regulation of testicular functions is clearly involved in rodents. It is essential for sperm production.
Yan Yang +13 more
doaj +1 more source
High Uric Acid Promotes Stem Leydig Cell Senescence by CCDC90B Mediates Mitochondrial Quality Control Imbalance. [PDF]
Cell ProlifIn hyperuricemia, uric acid inhibits CCDC90B ubiquitination degradation by binding to it. Excessive CCDC90B induces mitochondrial calcium overload, leading to mitochondrial quality control imbalance and ultimately resulting in SLC senescence and decreased testosterone levels.
Huang J +8 more
europepmc +2 more sources
A Short-Term Exposure to Tributyltin Blocks Leydig Cell Regeneration in the Adult Rat Testis
Frontiers in Pharmacology, 2017 Background: Tributyltin (TBT) is widely used as an antifouling agent that may cause reproductive toxicity. The mechanism of TBT on Leydig cell development is still unknown. The objective of the present study was to investigate whether a brief exposure to
Xiaolong Wu +11 more
doaj +1 more source
Aristaless related homeobox gene, Arx, is implicated in mouse fetal Leydig cell differentiation possibly through expressing in the progenitor cells. [PDF]
PLoS ONE, 2013 Development of the testis begins with the expression of the SRY gene in pre-Sertoli cells. Soon after, testis cords containing Sertoli and germ cells are formed and fetal Leydig cells subsequently develop in the interstitial space. Studies using knockout
Kanako Miyabayashi +7 more
doaj +1 more source