Results 71 to 80 of about 4,038 (203)

The Intersection of m6A Methylation and Immune Response in PCOS: A Bioinformatics Perspective

Immunity, Inflammation and Disease, Volume 14, Issue 2, February 2026.
N6‐methyladenosine RNA methylation regulators are intricately linked with the development of polycystic ovary syndrome (PCOS) and may influence immune cell infiltration in affected individuals. This study enhances our understanding of the molecular interactions in PCOS and suggests potential biomarkers for diagnosis and targets for therapeutic ...
Wenting Xu, Lingli Shi, Aifang Lu, Lijuan Cui, Haiqing Qian, Jiahui Wang, Mengyu Tang, Lili Zhu, Lihong Wang   +8 more
wiley   +1 more source

The INSL3-LGR8/GREAT Ligand-Receptor Pair in Human Cryptorchidism [PDF]

The Journal of Clinical Endocrinology & Metabolism, 2003
Testicular descent is a complex multistep embryonic process requiring the interaction between anatomical and hormonal factors. Failure in any of these steps results in cryptorchidism, the most frequent congenital anomaly of the urogenital tract in human males.
FERLIN, ALBERTO, SIMONATO M, BARTOLONI L, RIZZO G, BETTELLA A, DOTTORINI T, DALLAPICCOLA B, FORESTA, CARLO   +7 more
openaire   +3 more sources

Testicular cancer and cryptorchidism [PDF]

, 2013
The failure of testicular descent or cryptorchidism is the most common defect in newborn boys. The descent of the testes during development is controlled by insulin-like 3 peptide and steroid hormones produced in testicular Leydig cells, as well as by ...
Agoulnik, Alexander I., Ferguson, Lydia
core   +2 more sources

Progress in RNA‐Targeted Therapeutics for Human Diseases

MedComm, Volume 7, Issue 2, February 2026.
RNA‐targeted therapies are revolutionizing molecular medicine by transitioning from a “protein‐centric” focus to an “RNA‐regulatory network” approach. Leveraging RNA's diverse roles in gene regulation, signaling, and epigenetic modifications, advanced platforms such as ASOs, siRNA, miRNA, mRNA, aptamers, shRNA, and CRISPR/Cas systems are enabling ...
Wangzheqi Zhang, Aimin Jiang, Bin‐Kui Jia, Yuming Jin, Yinghu Chen, Zhaoyu Li, Yan Liao, Haoling Zhang, Zhiheng Lin, Xiao Fang, Linhui Wang   +10 more
wiley   +1 more source

Concerns about the widespread use of rodent models for human risk assessments of endocrine disruptors. [PDF]

, 2014
International audienceFetal testis is a major target of endocrine disruptors (EDs). During the last 20 years, we have developed an organotypic culture system that maintains the function of the different fetal testis cell types and have used this approach
Benachi, Alexandra, Delbes, Géraldine, Frydman, René, Grisin, Tiphany, Guerquin, Marie-Justine, Habert, René, Lambrot, Romain, Lehraiki, Abdelali, Levacher, Christine, Livera, Gabriel, Messiaen, Sébastien, Moison, Delphine, Muczynski, Vincent, N'Tumba-Byn, Thierry, Rouiller-Fabre, Virginie   +14 more
core   +5 more sources

Associations Between 40‐Year Trajectories of BMI and Proteomic and Epigenetic Aging Clocks: Deciphering Nonlinearity and Interactions

Aging Cell, Volume 25, Issue 2, February 2026.
In twins followed up over 40 years across adulthood, we examined associations between long‐term body mass index trajectories and downstream acceleration in proteomic and epigenetic aging. We further examined whether these associations showed statistical evidence for nonlinear patterns.
Gabin Drouard, M. Austin Argentieri, Aino Heikkinen, Miina Ollikainen, Jaakko Kaprio   +4 more
wiley   +1 more source

Regional perturbation of gene transcription is associated with intrachromosomal rearrangements and gene fusion transcripts in high grade ovarian cancer. [PDF]

, 2019
Genomic rearrangements are a hallmark of cancer biology and progression, allowing cells to rapidly transform through alterations in regulatory structures, changes in expression patterns, reprogramming of signaling pathways, and creation of novel ...
Beck, Tim, E Francis, Kyle, Krzyzanowski, Paul, La Rose, Jose, McPherson, John, Normand, Josee, Rottapel, Robert, Sircoulomb, Fabrice, Stein, Lincoln, Suarez, Fernando, Yousif, Fouad   +10 more
core   +2 more sources

Ex Vivo Spatiotemporal Characterization of Spermatogenesis in Mouse Testicular Organoids

Advanced Science, Volume 13, Issue 4, 19 January 2026.
To date, in vitro spermatogenesis remains a challenge in reproductive medicine. In this study, Sun et al. developed a promising in vitro strategy to generate testicular organoids that enable germ cells from newborn mice to enter meiosis, complete chromosome recombination and synapsis, and develop into haploid spermatids.
Jiachen Sun, Lifa Zhu, Yutong Li, Jinyan Tang, Tao Zhang, Hengjia Zhang, Wanchu Wang, Lufan Li, Shuhui Bian, Xin Wu   +9 more
wiley   +1 more source

Diethylstilbestrol Action on Leydig Cell Function and Testicular Descent

CHIMIA, 2008
Exposure to environmental chemicals may adversely affect the endocrine system and male sexual development. Testicular descent is regulated hormonally by Leydig-cell derived testosterone and Insulin-like factor 3 (Insl3).
Christopher R. Cederroth, Serge Nef
doaj   +1 more source

Effects of prenatal Leydig cell function on the ratio of the second to fourth digit lengths in school-aged children. [PDF]

PLoS ONE, 2015
Prenatal sex hormones can induce abnormalities in the reproductive system and adversely impact on genital development. We investigated whether sex hormones in cord blood influenced the ratio of the second to fourth digit lengths (2D/4D) in school-aged ...
Takahiko Mitsui, Atsuko Araki, Ayako Imai, Sakiko Sato, Chihiro Miyashita, Sachiko Ito, Seiko Sasaki, Takeya Kitta, Kimihiko Moriya, Kazutoshi Cho, Keita Morioka, Reiko Kishi, Katsuya Nonomura   +12 more
doaj   +1 more source