Results 71 to 80 of about 2,190 (162)

INSL3 Variation in Dogs Following Suppression and Recovery of the HPG Axis

Animals
Insulin-like peptide 3 (INSL3) is a constitutive product of mature, adult-type Leydig cells of the testes and consequently in most mammals is an ideal biomarker with which to monitor pubertal development.
Ravinder Anand-Ivell, Acacia Rebello Coutinho, Yanzhenzi Dai, Gary England, Sandra Goericke-Pesch, Richard Ivell   +5 more
doaj   +1 more source

Biomarcadores de hipogonadismo masculino en la infancia y la adolescencia

Advances in Laboratory Medicine, 2020
El eje hipotálamo-hipófiso-testicular es activo en la vida fetal y durante los primeros meses de la vida posnatal: la hipófisis secreta hormona luteinizante (LH) y folículo-estimulante (FSH), mientras que el testículo produce testosterona y factor ...
Rey Rodolfo A.
doaj   +1 more source

Distinct activation modes of the Relaxin Family Peptide Receptor 2 in response to insulin-like peptide 3 and relaxin

Scientific Reports, 2017
Relaxin family peptide receptor 2 (RXFP2) is a GPCR known for its role in reproductive function. It is structurally related to the human relaxin receptor RXFP1 and can be activated by human gene-2 (H2) relaxin as well as its cognate ligand insulin-like ...
Shoni Bruell, Ashish Sethi, Nicholas Smith, Daniel J. Scott, Mohammed Akhter Hossain, Qing-Ping Wu, Zhan-Yun Guo, Emma J. Petrie, Paul R. Gooley, Ross A. D. Bathgate   +9 more
doaj   +1 more source

Synthesis of fluorescent analogues of relaxin family peptides and their preliminary in vitro and in vivo characterization

Frontiers in Chemistry, 2013
Relaxin, a heterodimeric polypeptide hormone, is a key regulator of collagen metabolism and multiple vascular control pathways in humans and rodents.
Linda eChan, Linda eChan, Craig eSmith, Craig eSmith, Berenice eChua, Feng eLin, Ross eBathgate, Ross eBathgate, Ross eBathgate, Frances eSeparovic, Andrew eGundlach, Andrew eGundlach, M. Akhter eHossain, M. Akhter eHossain, M. Akhter eHossain, John eWade, John eWade, John eWade   +17 more
doaj   +1 more source

Relaxin gene family in teleosts: phylogeny, syntenic mapping, selective constraint, andexpression analysis

BMC Evolutionary Biology, 2009
Background In recent years, the relaxin family of signaling molecules has been shown to play diverse roles in mammalian physiology, but little is known about its diversity or physiology in teleosts, an infraclass of the bony fishes comprising ~ 50% of ...
Glen Peter, Bogerd Jan, Harron Scott, Yegorov Sergey, Good-Avila Sara V, Ozon James, Wilson Brian C   +6 more
doaj   +1 more source

Transcriptional Crosstalk between INSL3 and Androgen Receptor in Foetal Leydig Cells: Molecular Insights into TDS

Fertility & Reproduction
Testicular Dysgenesis Syndrome (TDS) encompasses a spectrum of male reproductive disorders that originate during fetal development. Among the critical players in testicular morphogenesis, fetal Leydig cells perform essential functions through the ...
Ajitha E. Veluthakunju, Sravanthi Puvvada, Sundaresan Saravana Kumar, Georgy Joy Eralil, Anupama Dhanapalan Chettiyar, Jayasudha Edatholath, Jineesh Valluvanga Chalil, Arun William, Aswathy Sundaresh, Dinesh Roy Divakaran   +9 more
doaj   +1 more source

Effects of Osteocalcin on Synthesis of Testosterone and INSL3 during Adult Leydig Cell Differentiation

International Journal of Endocrinology, 2019
Proliferation and differentiation of adult Leydig cells are mainly completed in puberty. In many studies, apart from normal postnatal development process, it is widely indicated that, through administrating EDS, Leydig cell population is eliminated and ...
Gulfidan Coskun, Leman Sencar, Abdullah Tuli, Dilek Saker, Mustafa Muhlis Alparslan, Sait Polat   +5 more
doaj   +1 more source

Novel INSL3 variants cause male infertility with cryptorchidism

Journal of Assisted Reproduction and Genetics
Cryptorchidism is one of the most prevalent male congenital abnormalities, affecting 1.6%-9% of newborn males, and it poses substantial risks to male fertility. INSL3 and its receptor RXFP2 play a major role in the first phase of the biphasic testicular descent process.
Chunjia Wei, Wenqing Lu, Yong Li, Yaoqiong Liang, Lanlan Meng, Chen Tan, Ge Lin, Yue-Qiu Tan, Qianjun Zhang, Chaofeng Tu, Juan Du   +10 more
openaire   +2 more sources

Association between maternal exposure to di(2-ethylhexyl) phthalate and reproductive hormone levels in fetal blood: the Hokkaido study on environment and children's health.

PLoS ONE, 2014
Prenatal di(2-ethylhexyl) phthalate (DEHP) exposure can produce reproductive toxicity in animal models. Only limited data exist from human studies on maternal DEHP exposure and its effects on infants.
Atsuko Araki, Takahiko Mitsui, Chihiro Miyashita, Tamie Nakajima, Hisao Naito, Sachiko Ito, Seiko Sasaki, Kazutoshi Cho, Tamiko Ikeno, Katsuya Nonomura, Reiko Kishi   +10 more
doaj   +1 more source

Possible association of serum trimethylamine N-oxide and INSL3 levels with the gut–testis axis in cryptorchidism

Discover Medicine
Cryptorchidism, a common congenital condition in male children, has been associated with impaired testicular function and increased risk of infertility.
Derya Ayvaci, Fadime Ovali, Mehmet Sarikaya, Metin Gunduz, Husamettin Vatansev   +4 more
doaj   +1 more source