Results 91 to 100 of about 4,038 (203)

Spatiotemporal mapping reveals Ccl8hi macrophages as key drivers of testicular inflammaging

Clinical and Translational Medicine, Volume 15, Issue 11, November 2025.
Spatiotemporal multi‐omics profiling establishes “inflammaging” — the age‐associated escalation of inflammatory signals — as a defining characteristic of testicular ageing. To deepen our investigation into the immune component of this process, we developed a refined sorting strategy based on the surface marker CD74, which significantly improves the ...
Yanping Huang, Jiahui Yao, Zhiqiang Zhang, Bin Ouyang, Jintao Zhuang, Xianshen Sha, Canhui Qu, Chengqiang Mo, Mujun Lu, Nanhe Lin, Xiangzhou Sun, Qiyun Yang, Yun Xie   +12 more
wiley   +1 more source

INSL3 Variation in Dogs Following Suppression and Recovery of the HPG Axis

Animals
Insulin-like peptide 3 (INSL3) is a constitutive product of mature, adult-type Leydig cells of the testes and consequently in most mammals is an ideal biomarker with which to monitor pubertal development.
Ravinder Anand-Ivell, Acacia Rebello Coutinho, Yanzhenzi Dai, Gary England, Sandra Goericke-Pesch, Richard Ivell   +5 more
doaj   +1 more source

A genomic atlas of human adrenal and gonad development [version 2; referees: 4 approved] [PDF]

, 2017
BACKGROUND: In humans, the adrenal glands and gonads undergo distinct biological events between 6-10 weeks post conception (wpc), such as testis determination, the onset of steroidogenesis and primordial germ cell development.
Achermann, JC, Barenco, M, Buonocore, F, del Valle, I, Duncan, AJ, Gerrelli, D, Hubank, M, Lin, L, Parnaik, R, Shah, S   +9 more
core   +4 more sources

Murine Models and Human Cell Line Models to Study Altered Dynamics of Ovarian Follicles in Polycystic Ovary Syndrome

Advanced Biology, Volume 9, Issue 7, July 2025.
The manuscript examines preclinical murine and human models to study polycystic ovary syndrome (PCOS), delving into the cellular and molecular mechanisms underlying altered ovarian follicular dynamics. It explores the cellular interactions involved in normal and PCOS ovaries and outlines the current and novel strategies in the search for preclinical ...
Arturo Bevilacqua, Cristiano Giuliani, Giovanna Di Emidio, Samuel H Myers, Vittorio Unfer, Carla Tatone   +5 more
wiley   +1 more source

Therian origin of INSL3/RXFP2-driven testicular descent in mammals

Frontiers in Cell and Developmental Biology
Introduction: During early development in most male mammals the testes move from a position near the kidneys through the abdomen to eventually reside in the scrotum.
Brandon R. Menzies, Gerard A. Tarulli, Stephen R. Frankenberg, Andrew J. Pask   +3 more
doaj   +1 more source

Utilidad de la hormona anti-mülleriana (AMH) y la inhibina B en el diagnóstico del hipogonadismo en el niño [PDF]

, 2014
Durante la infancia, el eje hipotálamo-hipófiso-testicular se encuentra parcialmente quiescente: bajan los niveles de gonadotrofinas y la secreción de testosterona disminuye siguiendo a la caída de la LH.
Ambao, Veronica Ana, Bedecarras, Patricia Gladys, Bergadá, Ignacio, Braslavsky, Débora, Campo, Stella Maris, Gottlieb, Silvia Elisa, Grinspon, Romina, Loreti, Nazareth, Rey, Rodolfo Alberto   +8 more
core   +1 more source

Synthesis of fluorescent analogues of relaxin family peptides and their preliminary in vitro and in vivo characterization

Frontiers in Chemistry, 2013
Relaxin, a heterodimeric polypeptide hormone, is a key regulator of collagen metabolism and multiple vascular control pathways in humans and rodents.
Linda eChan, Linda eChan, Craig eSmith, Craig eSmith, Berenice eChua, Feng eLin, Ross eBathgate, Ross eBathgate, Ross eBathgate, Frances eSeparovic, Andrew eGundlach, Andrew eGundlach, M. Akhter eHossain, M. Akhter eHossain, M. Akhter eHossain, John eWade, John eWade, John eWade   +17 more
doaj   +1 more source

Fetal testis and estrogenic endocrine disrupters [PDF]

, 2007
Des de fa ja molt temps, se sap que els estrògens tenen un paper molt important en la reproducció femenina, i hi ha ja també una forta evidència que poden també estar implicats en la regulació reproductiva masculina.
Habert, René, Levacher, Christine, Pairault, Catherine, Rouiller-Fabre, Virginie   +3 more
core  

Relaxin gene family in teleosts: phylogeny, syntenic mapping, selective constraint, andexpression analysis

BMC Evolutionary Biology, 2009
Background In recent years, the relaxin family of signaling molecules has been shown to play diverse roles in mammalian physiology, but little is known about its diversity or physiology in teleosts, an infraclass of the bony fishes comprising ~ 50% of ...
Glen Peter, Bogerd Jan, Harron Scott, Yegorov Sergey, Good-Avila Sara V, Ozon James, Wilson Brian C   +6 more
doaj   +1 more source

Female-to-male sex reversal in mice caused by transgenic overexpression of Dmrt1 [PDF]

, 2015
Genes related to Dmrt1, which encodes a DNA-binding DM domain transcription factor, act as triggers for primary sex determination in a broad range of metazoan species.
Koopman, Peter, Svingen, Terje, Ting Ng, Ee, Zhao, Liang   +3 more
core   +2 more sources