Results 21 to 30 of about 2,075 (199)

Physiology and evolution of the INSL3/RXFP2 hormone/receptor system in higher vertebrates

General and Comparative Endocrinology, 2020
Although the insulin-like peptide hormone INSL3 and its cognate receptor RXFP2 (relaxin-family peptide receptor 2) have existed throughout chordate evolution, their physiological diversification appears to be linked closely with mammalian emergence and radiation. In contrast, they have been lost in birds and reptiles.
Richard, Ivell, Waleed, Alhujaili, Tetsuya, Kohsaka, Ravinder, Anand-Ivell   +3 more
openaire   +4 more sources

The Different Ligand-Binding Modes of Relaxin Family Peptide Receptors RXFP1 and RXFP2 [PDF]

Molecular Endocrinology, 2012
Relaxin and insulin-like peptide 3 (INSL3) are peptide hormones with a number of important physiological roles in reproduction, regulation of extracellular matrix turnover, and cardiovascular function. Relaxin and INSL3 mediate their actions through the closely related G-protein coupled receptors, relaxin family peptide receptors 1 and 2 (RXFP1 and ...
Scott, Daniel J., Rosengren, K. Johan, Bathgate, Ross A. D.   +2 more
openaire   +6 more sources

Insulin-like factor 3 (INSL3) and the HPG axis in the male [PDF]

Frontiers in Endocrinology, 2014
The HPG (hypothalamo-pituitary-gonadal) axis comprises pulsatile GnRH from the hypothalamus impacting on the anterior pituitary to induce expression and release of both LH and FSH into the circulation.
Richard eIvell, Richard eIvell, Kee eHeng, Ravinder eAnand-Ivell   +3 more
doaj   +5 more sources

Genetic diversity and selection of Tibetan sheep breeds revealed by whole-genome resequencing [PDF]

Animal Bioscience, 2023
Objective This study aimed to elucidate the underlying gene regions responsible for productive, phenotypic or adaptive traits in different ecological types of Tibetan sheep and the discovery of important genes encoding valuable traits.
Dehong Tian, Buying Han, Xue Li, Dehui Liu, Baicheng Zhou, Chunchuan Zhao, Nan Zhang, Lei Wang, Quanbang Pei, Kai Zhao   +9 more
doaj   +2 more sources

Bi-allelic variants inINSL3andRXFP2cause bilateral cryptorchidism and male infertility [PDF]

Human Reproduction, 2023
AbstractSTUDY QUESTIONWhat is the impact of variants in the genes INSL3 (Insulin Like 3) and RXFP2 (Relaxin Family Peptide Receptor 2), respectively, on cryptorchidism and male infertility?SUMMARY ANSWERBi-allelic loss-of-function (LoF) variants in INSL3 and RXFP2 result in bilateral cryptorchidism and male infertility, whereas heterozygous variant ...
Ann-Kristin Dicke, Jakob Albrethsen, Bradley L Hoare, Margot J Wyrwoll, Alexander S Busch, Daniela Fietz, Adrian Pilatz, Clara Bühlmann, Anders Juul, Sabine Kliesch, Jörg Gromoll, Ross A D Bathgate, Frank Tüttelmann, Birgit Stallmeyer   +13 more
openaire   +4 more sources

Screening of molecular markers associated with hornless traits in Qira black sheep [PDF]

BMC Genomics
Hornless trait in sheep is one of the important traits affecting their economic production efficiency. In order to screen the molecular markers related to hornless trait in Qira black sheep, we used Illumina Ovine 50 K SNP chip data of 189 Qira black ...
Wen Zhou, Lijun Zhu, Yuwei Peng, Xiaopeng Li, Xuechen Zhang, Zhipeng Han, Jingping Li, Xinyu Bai, Qifeng Gao, Ruizhi Yang, Tao Jiang, Shudong Liu   +11 more
doaj   +2 more sources

The role of RXFP2 in mediating androgen-induced inguinoscrotal testis descent in LH receptor knockout mice [PDF]

Reproduction, 2010
Abstract LH receptor knockout (LhrKO) male mice exhibit a bilateral cryptorchidism resulting from a developmental defect in the gubernaculum during the inguinoscrotal phase of testis descent, which is corrected by testosterone replacement therapy (TRT).
F P, Yuan, X, Li, J, Lin, C, Schwabe, E E, Büllesbach, C V, Rao, Z M, Lei   +6 more
openaire   +3 more sources

Genome-Wide Association Analyses and Population Verification Highlight the Potential Genetic Basis of Horned Morphology during Polled Selection in Tibetan Sheep [PDF]

Animals
The types and morphology of sheep horns have been extensively researched, yet the genetic foundation underlying the emergence of diverse horn characteristics during the breeding of polled Tibetan sheep has remained elusive.
Dehong Tian, Zian Zhang, Bin Huang, Buying Han, Xue Li, Kai Zhao   +5 more
doaj   +2 more sources

Familial bilateral cryptorchidism is caused by recessive variants in RXFP2 [PDF]

Journal of Medical Genetics, 2019
Background Cryptorchidism or failure of testicular descent is the most common genitourinary birth defect in males. While both the insulin-like peptide 3 (INSL3) and its receptor, relaxin family peptide receptor 2 (RXFP2), have been demonstrated to control testicular descent in mice, their link to human ...
Katie Ayers, Rakesh Kumar, Gorjana Robevska, Shoni Bruell, Katrina Bell, Muneer A Malik, Ross A Bathgate, Andrew Sinclair   +7 more
openaire   +4 more sources

Relaxin Receptor RXFP1 and RXFP2 Expression in Ligament, Tendon, and Shoulder Joint Capsule of Rats [PDF]

Journal of Korean Medical Science, 2016
Numerous musculoskeletal disorders are caused by thickened ligament, tendon stiffness, or fibrosis of joint capsule. Relaxin, a peptide hormone, can exert collagenolytic effect on ligamentous and fibrotic tissues. We hypothesized that local injection of relaxin could be used to treat entrapment neuropathy and adhesive capsulitis.
Jae Hyung Kim, Sang Kwang Lee, Seong Kyu Lee, Joo Heon Kim, Michael Fredericson   +4 more
openaire   +3 more sources