Results 21 to 30 of about 1,025 (152)
Profiling insulin like factor 3 (INSL3) signaling in human osteoblasts. [PDF]
PLoS ONE, 2011 BACKGROUND: Young men with mutations in the gene for the INSL3 receptor (Relaxin family peptide 2, RXFP2) are at risk of reduced bone mass and osteoporosis.
Alberto Ferlin +4 more
doaj +1 more source
Genetic diversity and selection of Tibetan sheep breeds revealed by whole-genome resequencing [PDF]
Animal Bioscience, 2023 Objective This study aimed to elucidate the underlying gene regions responsible for productive, phenotypic or adaptive traits in different ecological types of Tibetan sheep and the discovery of important genes encoding valuable traits.
Dehong Tian +9 more
doaj +1 more source
Familial bilateral cryptorchidism is caused by recessive variants in RXFP2 [PDF]
Journal of Medical Genetics, 2019 Background Cryptorchidism or failure of testicular descent is the most common genitourinary birth defect in males. While both the insulin-like peptide 3 (INSL3) and its receptor, relaxin family peptide receptor 2 (RXFP2), have been demonstrated to control testicular descent in mice, their link to human ...
Katie Ayers +7 more
openaire +3 more sources
Structural insights into the modes of relaxin-binding and tethered-agonist activation of RXFP1 and RXFP2 [PDF]
Journal of Molecular Biology, 2021 Abstract Our poor understanding of the mechanism by which the peptide-hormone H2 relaxin activates its G protein coupled receptor, RXFP1 and the related receptor RXFP2, has hindered progress in its therapeutic development. Both receptors possess large ectodomains, which bind H2 relaxin, and contain an N-terminal LDLa module that is ...
Ashish Sethi +14 more
openaire +3 more sources
Discovery of small molecule agonists of the Relaxin Family Peptide Receptor 2
Communications Biology, 2022 Specific small molecule RXFP2 agonists with favorable pharmacokinetic properties induce gubernacular invagination in mouse embryos, increase mineralization activity in human osteoblasts in vitro, and improve bone trabecular parameters in adult mice.
Maria Esteban-Lopez +17 more
doaj +1 more source
Frontiers in Endocrinology, 2013 Relaxin family peptide (RXFP) receptors 1 and 2 are unique G-protein coupled receptors in that they contain an N-terminal low density lipoprotein type A (LDLa) module which is necessary for receptor activation.
Shoni eBruell +14 more
doaj +1 more source
Luteal and hypophyseal expression of the canine relaxin (RLN) system during pregnancy: Implications for luteotropic function. [PDF]
PLoS ONE, 2018 By acting through its receptors (RXFP1, RXFP2), relaxin (RLN) exerts species-specific effects during pregnancy; possible luteotropic effects through stimulation of prolactin (PRL) release have been suggested.
Marta Nowak +2 more
doaj +1 more source
In a Class of Their Own – RXFP1 and RXFP2 are Unique Members of the LGR Family [PDF]
Frontiers in Endocrinology, 2015 The leucine-rich repeat-containing G protein-coupled receptors (LGRs) family consists of three groups: types A, B, and C and all contain a large extracellular domain (ECD) made up of the structural motif - the leucine-rich repeat (LRR). In the LGRs, the ECD binds the hormone or ligand, usually through the LRRs, that ultimately results in activation and
Emma June Petrie +9 more
openaire +4 more sources
Frontiers in Physiology, 2022 Mammalian relaxin (RLN) family peptides binding their receptors (RXFPs) play a variety of roles in many physiological processes, such as reproduction, stress, appetite regulation, and energy balance.
Can Lv +13 more
doaj +1 more source
Protective Role of Testicular Hormone INSL3 From Atrophy and Weakness in Skeletal Muscle
Frontiers in Endocrinology, 2018 Androgens are primarily involved in muscle growth, whilst disease-driven muscle wasting is frequently associated with hypogonadism. The Leydig cells of the testes also produce the peptide-hormone Insulin-like peptide 3 (INSL3).
Alberto Ferlin +9 more
doaj +1 more source