Therian origin of INSL3/RXFP2-driven testicular descent in mammals [PDF]
Frontiers in Cell and Developmental BiologyIntroduction: During early development in most male mammals the testes move from a position near the kidneys through the abdomen to eventually reside in the scrotum.
Brandon R. Menzies +3 more
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Author Correction: Discovery of RXFP2 genetic association in resistant hypertensive men and RXFP2 antagonists for the treatment of resistant hypertension [PDF]
Scientific ReportsShan-Shan Zhang +29 more
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Revealing the endocrine landscape of INSL3/RXFP2 signaling in hamster [PDF]
PLoS ONEIn mammals, insulin-like peptide 3 (INSL3) and its cognate receptor (RXFP2) are reported to be essential regulators of male reproductive physiology. It is also believed that INSL3/RXFP2 signaling has a role in female ovarian function and follicle development, although its exact mechanisms and functions are still being studied.
Aidet Ruiz, Luis Ramos
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The RXFP2-PLC/PKC signaling pathway mediates INSL3-induced regulation of the proliferation, migration and apoptosis of mouse gubernacular cells [PDF]
Cellular & Molecular Biology Letters, 2023 Background Testicular hypoplasia can affect the sexual and reproductive ability in adulthood, and even increase the risk of cancer. Abnormal development of the gubernaculum is one of the important factors of testicular hypoplasia.
Shouxing Duan +12 more
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RXFP2-positive mesenchymal stem cells in the antlerogenic periosteum contribute to postnatal development of deer antlers [PDF]
Communications BiologyThe postnatal development of secondary sexual characteristics is a highly complex process governed by diverse molecular signals and serves as a key marker of sexual maturity.
Hengxing Ba +8 more
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The fate of spermatogonial stem cells in the cryptorchid testes of RXFP2 deficient mice. [PDF]
PLoS ONE, 2013 The environmental niche of the spermatogonial stem cell pool is critical to ensure the continued generation of the germ cell population. To study the consequences of an aberrant testicular environment in cryptorchidism we used a mouse model with a ...
Lydia Ferguson +2 more
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Achieving an optimal pregnancy outcome through the combined utilization of micro-TESE and ICSI in cryptorchidism associated with a non-canonical splicing variant in RXFP2 [PDF]
Journal of Assisted Reproduction and GeneticsKuokuo Li, Mingrong Lv, Dongdong Tang
exaly +4 more sources
Structural insights into the modes of relaxin-binding and tethered-agonist activation of RXFP1 and RXFP2 [PDF]
Journal of Molecular Biology, 2021 Abstract Our poor understanding of the mechanism by which the peptide-hormone H2 relaxin activates its G protein coupled receptor, RXFP1 and the related receptor RXFP2, has hindered progress in its therapeutic development. Both receptors possess large ectodomains, which bind H2 relaxin, and contain an N-terminal LDLa module that is ...
Ashish Sethi +14 more
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Indian Journal of Animal Sciences, 2019 The polymorphism in ovine relaxin family peptide receptor 2 gene and the relevance of earlier established human and mice cryptorchidism associated SNP’s in Mandya and Hassan Sheep was studied. Genomic DNA was extracted from 60 cryptorchid and 80 normal
G S NAVEEN KUMAR +4 more
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In a Class of Their Own – RXFP1 and RXFP2 are Unique Members of the LGR Family [PDF]
Frontiers in Endocrinology, 2015 The leucine-rich repeat-containing G protein-coupled receptors (LGRs) family consists of three groups: types A, B, and C and all contain a large extracellular domain (ECD) made up of the structural motif - the leucine-rich repeat (LRR). In the LGRs, the ECD binds the hormone or ligand, usually through the LRRs, that ultimately results in activation and
Emma June Petrie +9 more
openaire +5 more sources