Results 11 to 20 of about 1,025 (152)

Therian origin of INSL3/RXFP2-driven testicular descent in mammals [PDF]

Frontiers in Cell and Developmental Biology
Introduction: During early development in most male mammals the testes move from a position near the kidneys through the abdomen to eventually reside in the scrotum.
Brandon R. Menzies, Gerard A. Tarulli, Stephen R. Frankenberg, Andrew J. Pask   +3 more
doaj   +5 more sources

Author Correction: Discovery of RXFP2 genetic association in resistant hypertensive men and RXFP2 antagonists for the treatment of resistant hypertension [PDF]

Scientific Reports
Shan-Shan Zhang, Lance Larrabee, Andrew H. Chang, Sapna Desai, Lisa Sloan, Xin Wang, Yixuan Wu, Nazia Parvez, Karen Amaratunga, Allison C. Hartman, Abby Whitnall, Joseph Mason, Nicholas P. Barton, Audrey Y. Chu, Jonathan M. Davitte, Adam J. Csakai, Caitlin Vestal Tibbetts, Audrey E. Tolbert, Heather O’Keefe, Jessie Polanco, Joseph Foley, Casey Kmett, Jonathan Kehler, Gabriela Kozejova, Feng Wang, Andrew P. Mayer, Patrick Koenig, Davide Foletti, Steven J. Pitts, Christine G. Schnackenberg   +29 more
doaj   +3 more sources

Revealing the endocrine landscape of INSL3/RXFP2 signaling in hamster [PDF]

PLoS ONE
In mammals, insulin-like peptide 3 (INSL3) and its cognate receptor (RXFP2) are reported to be essential regulators of male reproductive physiology. It is also believed that INSL3/RXFP2 signaling has a role in female ovarian function and follicle development, although its exact mechanisms and functions are still being studied.
Aidet Ruiz, Luis Ramos
doaj   +5 more sources

The fate of spermatogonial stem cells in the cryptorchid testes of RXFP2 deficient mice. [PDF]

PLoS ONE, 2013
The environmental niche of the spermatogonial stem cell pool is critical to ensure the continued generation of the germ cell population. To study the consequences of an aberrant testicular environment in cryptorchidism we used a mouse model with a ...
Lydia Ferguson, Javier J How, Alexander I Agoulnik   +2 more
doaj   +5 more sources

Genome-wide association study for polledness, horn shape, and wool traits in Original Valachian sheep [PDF]

Archives Animal Breeding
The Original Valachian sheep is an endangered Slovak national breed that is well adapted to high-altitude pastures. The sheep can be horned with various shapes and can have multi-coloured or completely white or black wool.
M. Mészárosová, G. Mészáros, N. Moravčíková, I. Pavlík, M. Margetín, R. Kasarda   +5 more
doaj   +2 more sources

Insulin-like peptide 3 is not a biomarker for pancreatic ductal adenocarcinoma [PDF]

Frontiers in Endocrinology
Pancreatic ductal carcinoma (PDAC) is a rapidly growing cancer with a very poor prognosis. It is, therefore, important to develop novel, specific biomarkers to identify such cancers as early as possible.
Ravinder Anand-Ivell, Xinyuan Yang, Ruediger Braun, Hendrik Ungefroren, Richard Ivell, Richard Ivell   +5 more
doaj   +2 more sources

Relaxin-2: Shaping the Proteomic Landscape of Skeletal Muscle Physiology, Glucose Trafficking, and Mitochondrial Function in Rat. [PDF]

FASEB J
Cardioprotective hormone relaxin‐2 showed relevant effects on rat skeletal muscle by altering proteins linked to muscle function, regeneration, differentiation, mitochondrial function, glucose metabolism, and structural integrity and organization. Specifically, relaxin‐2 reduced the expression of 95 proteins, increased 32, and elicited unique proteins ...
Vázquez-Abuín X, Gómez-Cibeira L, García-Seara J, de la Fuente-López P, Minguito-Carazo C, Bravo SB, Otero-Santiago M, Gualillo O, González-Juanatey JR, Lago F, Feijóo-Bandín S, Aragón-Herrera A.   +11 more
europepmc   +2 more sources

The impact of breast milk relaxin 2, oxytocin, and insulin-like peptide 3 on neonatal growth parameters in early life. [PDF]

J Pediatr Gastroenterol Nutr
Abstract Objectives This study aims to quantify the levels of relaxin 2 (RLX2), oxytocin (OXT), and insulin‐like peptide 3 (INSL3) in colostrum (postpartum days 1–5, Visit 1) and mature breast milk (postpartum days 21–35, Visit 2), and to evaluate their associations with neonatal growth outcomes.
Doneray H, Ozden A, Tavlas G, Ozkan HI.
europepmc   +2 more sources

Genomic Insights into the Origin, High Fecundity and Environmental Adaptation of Hu Sheep. [PDF]

Adv Sci (Weinh)
The Hu sheep diverged from the Small‐tailed Han sheep ≈1330 years ago, and subsequently migrated from northern to warm and humid southern regions. The genes BMPR1B, UNC5C, and GRID2 play a synergistic role in the superior reproductive traits of Hu sheep.
Liu Z, Zhang N, Wen Z, Wang H, Li T, Ma R, Li M, Wang D, Shu H, Huang X, Han J, Zhao Y, Liu Q.   +12 more
europepmc   +2 more sources

Achieving an optimal pregnancy outcome through the combined utilization of micro-TESE and ICSI in cryptorchidism associated with a non-canonical splicing variant in RXFP2 [PDF]

Journal of Assisted Reproduction and Genetics
Mingrong Lv, Dongdong Tang, Kuokuo Li
exaly   +2 more sources