Results 31 to 40 of about 1,276 (166)
Reproductive Biology and Endocrinology, 2007 Background Relaxin is the endogenous ligand of the G-protein coupled receptor RXFP1, previously known as LGR7. In humans relaxin can also activate, but with lower affinity, the closely related receptor for the insulin-like peptide from Leydig cells ...
Porto Catarina S +6 more
doaj +1 more source
Multi-Component Mechanism of H2 Relaxin Binding to RXFP1 through NanoBRET Kinetic Analysis
iScience, 2019 Summary: The peptide hormone H2 relaxin has demonstrated promise as a therapeutic, but mimetic development has been hindered by the poorly understood relaxin receptor RXFP1 activation mechanism.
Bradley L. Hoare +8 more
doaj +1 more source
Changes in Knee Laxity and Relaxin Receptor Isoforms Expression (RXFP1/RXFP2) in the Knee throughout Estrous Cycle Phases in Rodents. [PDF]
PLoS ONE, 2016 The changes in knee laxity and relaxin receptor expression at different phases of rodent estrous cycle are not known. Here, changes in the parameter were investigated in rats at different phases of the estrous cycle. Estrous cycle phases of intact female
Firouzeh Dehghan +6 more
doaj +1 more source
Relaxin-Family Peptide Receptors 1 and 2 Are Fully Functional in the Bovine
Frontiers in Physiology, 2017 In most mammals the peptide hormone relaxin is a key physiological component regulating early pregnancy and birth. However, synteny analysis shows that the gene encoding ovarian relaxin-2 is deleted in cows and sheep.
Yanzhenzi Dai +8 more
doaj +1 more source
Frontiers in Physiology, 2022 Mammalian relaxin (RLN) family peptides binding their receptors (RXFPs) play a variety of roles in many physiological processes, such as reproduction, stress, appetite regulation, and energy balance.
Can Lv +13 more
doaj +1 more source
C1q/TNF‐related peptide 8 (CTRP8) promotes temozolomide resistance in human glioblastoma
Molecular Oncology, 2018 The C1q/TNF‐related peptide 8 (CTRP8) has recently emerged as a novel ligand of the G protein‐coupled receptor RXFP1 in the fatal brain tumor glioblastoma (GBM). We previously demonstrated that the CTRP8‐RXFP1 ligand–receptor system promotes motility and
Thatchawan Thanasupawat +8 more
doaj +1 more source
Frontiers in Endocrinology, 2013 Relaxin family peptide (RXFP) receptors 1 and 2 are unique G-protein coupled receptors in that they contain an N-terminal low density lipoprotein type A (LDLa) module which is necessary for receptor activation.
Shoni eBruell +14 more
doaj +1 more source
Disturbed relaxin signaling pathway and testicular dysfunction in mouse offspring upon maternal exposure to simazine. [PDF]
PLoS ONE, 2012 Simazine is a triazine herbicide that is being widely applied worldwide and commonly detected in surface and groundwater. Despite its popular use in controlling weeds and algae, very limited information is available regarding its toxicity. In the present
Ho-Oak Park, Jeehyeon Bae
doaj +1 more source
Pathology and Oncology Research, 2022 Purpose: Lung adenocarcinoma is one of the most common malignancies. Though some historic breakthroughs have been made in lung adenocarcinoma, its molecular mechanisms of development remain elusive.
Yuning Xie +8 more
doaj +1 more source
RXFP1 is targeted by complement C1q Tumor Necrosis Factor-related factor 8 (CTRP8) in brain cancer
Frontiers in Endocrinology, 2015 The relaxin-like - RXFP1 ligand-receptor system has important functions in tumor growth and tissue invasion. Recently, we have identified the secreted protein, CTRP8, a member of the C1q/ Tumor Necrosis Factor-related protein (CTRP) family, as a novel ...
Thatchawan eThanasupawat +6 more
doaj +1 more source