Identification and Characterization of a Distal Enhancer in RXFP1 Gene [PDF]
A62. LUNG FIBROSIS: INSIGHTS FROM THE BENCH, 2020 T.-Y. Chen +8 more
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Spatial-temporal regulation of the prostanoid receptor EP2 co-ordinates PGE2-mediated cAMP signaling in decidualizing human endometrium [PDF]
iScienceSummary: Decidualization denotes the differentiation of endometrial stromal cells into specialized decidual cells, essential for embryo implantation and pregnancy.
Paul J. Brighton +7 more
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The role of relaxins in blood cell modulation: interactions with relaxin family peptide receptor 1 (RXFP1) and glucocorticoid receptor (GR) [PDF]
Clin Sci (Lond)Weronika Broszkiewicz, Kamila Domińska
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The Relaxin Receptor (RXFP1) Utilizes Hydrophobic Moieties on a Signaling Surface of Its N-terminal Low Density Lipoprotein Class A Module to Mediate Receptor Activation [PDF]
Journal of Biological Chemistry, 2013 Biswaranjan Mohanty +2 more
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The complex binding mode of the peptide hormone H2 relaxin to its receptor RXFP1 [PDF]
Nature Communications, 2016 The mechanism by which relaxin activates the relaxin family peptide receptor-1 is poorly understood. Here, Sethi et al.identify a relaxin binding site in an extracellular linker between the LDLa and LRR domains and propose that relaxin binding stabilizes
Ashish Sethi +7 more
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تاثیر پنج هفته تمرین تناوبی شدید بر بیان ژنهای RXFP1 و CTGF بافت قلبی و آنزیم کبدی SGPT در رتهای ویستار نر مبتلا به کبد چرب [PDF]
Majallah-i Dānishkadah-i Pizishkī-i Dānishgāh-i ̒ Ulūm-i Pizishkī-i Mashhad., 2022 زمینه و هدف: در سالهای اخیر مطالعاتی درموردارتباط کبدچرب و آتروسکلروزیس انجام شده است که نتایج این مطالعات، حاکی از ارتباط کبد چرب غیرالکلی با آترواسکلروزیس عروق کرونری می باشد. کبد چرب با افزایش خطر بیماریهای قلبی- عروقی همراهی دارد.
مسعود حمزه لو +2 more
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Novel Relaxin Receptor RXFP1 Agonist AZD3427 in the Treatment of Heart Failure: A Phase 1a/b, First‐in‐Human, Randomized, Single‐Blind, Placebo‐Controlled Study [PDF]
Journal of the American Heart Association: Cardiovascular and Cerebrovascular DiseaseBackground Heart failure mortality remains high despite recent progress in pharmacological treatment. AZD3427 is a selective long‐acting analog of relaxin, a vasodilatory hormone with antifibrotic effects.
Kathleen Connolly +15 more
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The relaxin receptor RXFP1 signals through a mechanism of autoinhibition [PDF]
Nature Chemical Biology, 2022 Abstract The relaxin family peptide receptor 1 (RXFP1) is the receptor for relaxin-2, an important regulator of reproductive and cardiovascular physiology. RXFP1 is a multi-domain G protein-coupled receptor (GPCR) with an ectodomain consisting of an LDLa module and leucine-rich repeats.
Sarah C. Erlandson +10 more
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Development of a scaffold displaying exoloops of RXFP1
Italian Journal of Anatomy and Embryology, 2014 Relaxin family peptide receptor 1 (RXFP1), the cognate receptor for relaxin, is a G-protein coupled receptor (GPCR) possessing a unique extracellular region consisting of a domain of 10 leucine rich repeats (LRRs) linked to an N-terminal low density lipoprotein Class A module.
Natalie Diepenhorst +3 more
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Constitutive formation of an RXFP1‐signalosome: a novel paradigm in GPCR function and regulation [PDF]
British Journal of Pharmacology, 2011 The classical second messenger cAMP is important in diverse physiological processes, where its spatial and temporal compartmentalization allows precise control over multiple cellular events. Within this context, G‐protein‐coupled receptors (GPCRs) govern specialized pools of cAMP, which are functionally specific for the unique cellular effects ...
Michelle L. Halls
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