Results 41 to 50 of about 2,484 (221)

Relaxin/RXFP1 Signaling in Prostate Cancer Progression [PDF]

Annals of the New York Academy of Sciences, 2009
We found that relaxin peptide expression is significantly elevated in recurrent human prostate cancer. Stimulation with relaxin increased migration, invasiveness, proliferation, and adhesion of LNCaP and PC3 cells in vitro. Opposite effects on cellular phenotype were observed after suppression of endogenous relaxin/RXFP1 expression or signaling.
Shu Feng, Irina U. Agoulnik, Zhen Li, Hee Dong Han, Gabriel Lopez‐Berestein, Anil K. Sood, Michael Ittmann, Alexander I. Agoulnik   +7 more
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Analgesic effect of central relaxin receptor activation on persistent inflammatory pain in mice: behavioral and neurochemical data

PAIN Reports, 2021
. Introduction:. The relaxin peptide signaling system is involved in diverse physiological processes, but its possible roles in the brain, including nociception, are largely unexplored. Objective:.
Cynthia Abboud, Louison Brochoire, Adèle Drouet, M. Akhter Hossain, Walid Hleihel, Andrew L. Gundlach, Marc Landry   +6 more
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Novel CTRP8‐RXFP1‐JAK3‐STAT3 axis promotes Cdc42‐dependent actin remodeling for enhanced filopodia formation and motility in human glioblastoma cells

Molecular Oncology, 2022
C1q tumor necrosis factor‐related peptide 8 (CTRP8) is the least studied member of the C1Q‐TNF‐related peptide family. We identified CTRP8 as a ligand of the G protein‐coupled receptor relaxin family peptide receptor 1 (RXFP1) in glioblastoma multiforme (
Aleksandra Glogowska, Thatchawan Thanasupawat, Jason Beiko, Marshall Pitz, Sabine Hombach‐Klonisch, Thomas Klonisch   +5 more
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Characterization and developmental expression pattern of the relaxin receptor rxfp1 gene in zebrafish [PDF]

Development, Growth & Differentiation, 2010
We report the gene characterization, the cDNA cloning and the temporal and spatial expression pattern of the relaxin receptor rxfp1 gene in the zebrafish Danio rerio. The zebrafish rxfp1 gene has the same syntenic genomic organization, and a similar exon‐intron structure to the homologue human gene. Furthermore, the deduced Rxfp1 protein sequence shows
Aldo Donizetti, Marcella Fiengo, Rosanna del Gaudio, Rossella Di Giaimo, Sergio Minucci, Francesco Aniello   +5 more
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Emerging roles for the RXFP1 in myeloid series leukemia

International Journal of Medical Science and Clinical Invention
Purpose: The study investigates the role of Relaxin Family Peptide Receptor 1 (RXFP1) in myeloid leukemia cell function. It found that RXFP1 has been associated with cAMP, PI3K/Akt, NO/cGMP, MAPK and ERK1/2 signaling. High RXFP1 expression was associated with shorter cancer-specific survival RXFP1 mutated leukemia patients.
Ayriana Safari Baesmat, Berna Bayrakdar
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Human relaxins (RLNH1, RLNH2), their receptor (RXFP1) and fetoplacental growth [PDF]

Reproduction, 2017
Abstract Relaxin, a systemic and placental hormone, has potential roles in fetoplacental growth. Human placenta expresses two RLN genes, RLNH1 and RLNH2. Maternal obesity is common and is associated with abnormal fetal growth. Our aims were to relate systemic and cord blood RLNH2, placental RLNs and their receptor (RXFP1) with ...
Kelly Yamasato, Pai-Jong Stacy Tsai, James W. Davis, Sandra Y. Yamamoto, Gillian D. Bryant‐Greenwood   +4 more
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The effect of high intensity interval training on CTGF and RXFP1 genes expression of heart tissue and SGPT liver enzyme in rats with fatty liver [PDF]

Journal of Exercise & Organ Cross Talk, 2022
This study investigated the effect of high intensity interval training on CTGF and RXFP1 genes expression of heart tissue and SGPT liver enzyme in rats with fatty liver.
Masoud Hamzehloo, Mania Roozbayani
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Characterization of Relaxin Receptor (RXFP1) Desensitization and Internalization in Primary Human Decidual Cells and RXFP1-Transfected HEK293 Cells [PDF]

Endocrinology, 2008
We report here the desensitization and internalization of the relaxin receptor (RXFP1) after agonist activation in both primary human decidual cells and HEK293 cells stably transfected with RXFP1. The importance of beta-arrestin 2 in these processes has also been demonstrated.
András, Kern, Gillian D, Bryant-Greenwood   +1 more
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Rh-relaxin-2 attenuates degranulation of mast cells by inhibiting NF-κB through PI3K-AKT/TNFAIP3 pathway in an experimental germinal matrix hemorrhage rat model

Journal of Neuroinflammation, 2020
Background Mast cells play an important role in early immune reactions in the brain by degranulation and the consequent inflammatory response. Our aim of the study is to investigate the effects of rh-relaxin-2 on mast cells and the underlying mechanisms ...
Peng Li, Gang Zhao, Fanfan Chen, Yan Ding, Tianyi Wang, Shengpeng Liu, Weitian Lu, Weilin Xu, Jerry Flores, Umut Ocak, Tongyu Zhang, John H. Zhang, Jiping Tang   +12 more
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Development of human cells with RXFP1 knockdown using retroviral delivery of microRNA against human RXFP1

Italian Journal of Anatomy and Embryology, 2014
To study the specifi c actions of relaxin through RXFP1 in human cells, it would be advantageous to develop cell populations with permanent RXFP1 knockdown (KD). We have developed and assessed four microRNA against human RXFP1. One of the four designed microRNA displayed signifi cant RXFP1 KD as assessed by reduced relaxin binding when co-transfected ...
Kelvin J. Yong, Gabrielle E. Callander, Rebecca J. Bergin, Chrishan S. Samuel, Ross A. D. Bathgate   +4 more
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