Results 61 to 70 of about 1,276 (166)
Recent advances of nanomaterials in imaging liver fibrosis
BMEMat, Volume 3, Issue 2, June 2025.Schematic summary on the latest strategies of liver fibrosis imaging based on various nanomaterials. Abstract Liver fibrosis is a pathological process resulting from prolonged exposure to various injury factors. It is characterized by the abnormal proliferation and activation of hepatic stellate cells and excessive deposition of extracellular matrix ...
Jin Cui +11 more
wiley +1 more source
ESC Heart Failure, Volume 12, Issue 3, Page 1956-1964, June 2025.Abstract Aims Despite receiving guideline‐directed medical heart failure (HF) therapy, patients with pulmonary hypertension associated with left heart disease (PH‐LHD) experience higher mortality and hospitalization rates than the general HF population.
Marcin Ufnal +17 more
wiley +1 more source
The Different Ligand-Binding Modes of Relaxin Family Peptide Receptors RXFP1 and RXFP2 [PDF]
Molecular Endocrinology, 2012 Relaxin and insulin-like peptide 3 (INSL3) are peptide hormones with a number of important physiological roles in reproduction, regulation of extracellular matrix turnover, and cardiovascular function. Relaxin and INSL3 mediate their actions through the closely related G-protein coupled receptors, relaxin family peptide receptors 1 and 2 (RXFP1 and ...
Scott, Daniel J. +2 more
openaire +5 more sources
Genes, Brain and Behavior, Volume 24, Issue 3, June 2025.Enriched environment housing reverses memory deficits in middle‐aged WMI females and attenuates deficits in WMI males. Plasma levels of estradiol and hippocampal gene expression followed the same pattern as memory in WMI females following environmental enrichment and may be involved in reversing the effects of aging on cognitive decline.
Michelle T. Ji +9 more
wiley +1 more source
Hormone receptor expression in human fascial tissue
European Journal of Histochemistry, 2016 Many epidemiologic, clinical, and experimental findings point to sex differences in myofascial pain in view of the fact that adult women tend to have more myofascial problems with respect to men. It is possible that one of the stimuli to sensitization of
C. Fede +6 more
doaj +1 more source
Robust Spatial Cell‐Type Deconvolution with Qualitative Reference for Spatial Transcriptomics
Small Methods, Volume 9, Issue 5, May 17, 2025.QR‐SIDE is a robust method to integrate cell‐type deconvolution and domain detection for spatial transcriptomics. By leveraging marker genes and spatial information, it uncovers tissue architecture and cell‐type compositions. Its adaptive modeling ensures resilience to noisy markers, and its flexibility supports applications across resolutions ...
Qishi Dong +5 more
wiley +1 more source
The Clinical Respiratory Journal, Volume 19, Issue 5, May 2025.This integrated analysis demonstrates the involvements of G protein‐coupled receptors (GPCRs) in lung adenocarcinoma developments and proves the potential of five key GPCRs as prognostic biomarkers and targets in lung adenocarcinoma. ABSTRACT Background G protein‐coupled receptors (GPCRs), the largest family of cell‐surface molecules involve in various
Feiyan Yang +3 more
wiley +1 more source
Population Genetic Analysis of Ten Geographically Isolated Tibetan Pig Populations
Animals, 2020 Several geographically isolated populations of Tibetan pigs inhabit the high-altitude environment of the Tibetan Plateau. Their genetic relationships, contribution to the pool of genetic diversity, and their origin of domestication are unclear.
Peng Shang +6 more
doaj +1 more source
Journal of Biomedical Materials Research Part B: Applied Biomaterials, Volume 113, Issue 3, March 2025.ABSTRACT Despite advances in the design and protocols for maintaining the skin/device interface around percutaneous devices (PDs), no current strategy ensures the permanent attachment of peri‐implant epithelial tissue to the device surface. Based on preliminary data, we hypothesized that PDs coated with keratin nanomaterials, resembling the fingernail ...
Andrew Miller +6 more
wiley +1 more source
Targeting Fibrosis: From Molecular Mechanisms to Advanced Therapies
Advanced Science, Volume 12, Issue 3, January 20, 2025.This review comprehensively summarizes the advances in research for fibrosis. It emphasizes organ‐specific profibrotic cell types and molecular mechanisms of fibrosis, especially in the kidney, liver, lung, and heart. The authors highlight the advanced antifibrotic small molecule drugs and cellular therapies for fibrosis.
Xingpeng Di +4 more
wiley +1 more source