Results 61 to 70 of about 2,484 (221)

RXFP1 expression is activated in the brains of humans with epilepsy.

Mamoor, Shahan
openalex   +3 more sources

Anti-apoptotic and Matrix Remodeling Actions of a Small Molecule Agonist of the Human Relaxin Receptor, ML290 in Mice With Unilateral Ureteral Obstruction

Frontiers in Physiology, 2021
Diseases, such as diabetes and hypertension, often lead to chronic kidney failure. The peptide hormone relaxin has been shown to have therapeutic effects in various organs.
Hooi Hooi Ng, Mariluz Soula, Bryan Rivas, Kenneth J. Wilson, Juan J. Marugan, Alexander I. Agoulnik   +5 more
doaj   +1 more source

Cell surface engineering of renal cell carcinoma with glycosylphosphatidylinositol-anchored TIMP-1 blocks TGF-beta 1 activation and reduces regulatory ID gene expression [PDF]

, 2012
Tissue inhibitor of metalloproteinase 1 (TIMP-1) controls matrix metalloproteinase activity through 1:1 stoichiometric binding. Human TIMP-1 fused to a glycosylphosphatidylinositol (GPI) anchor (TIMP-1-GPI) shifts the activity of TIMP-1 from the ...
Djafarzadeh, Roghieh, Hofstetter, Monika, Jaeckel, Carsten, Nelson, Peter J., Notohamiprodjo, Susan, Rieth, Nicole   +5 more
core   +2 more sources

Novel Insights into the Bovine Polled Phenotype and Horn Ontogenesis in Bovidae [PDF]

, 2013
Despite massive research efforts, the molecular etiology of bovine polledness and the developmental pathways involved in horn ontogenesis are still poorly understood.
Allais-Bonnet, Aurélie, Barbey, Sarah, Baur, Aurélia, Bernard-Capel, Carine, Blum, Helmut, Boichard, Didier, Bouet, Stéphan, Boussaha, Mekki, Capitan, Aurélien, Catros, Olivier, Clément, Laetitia, Cobo, Emilie, Djari, Anis, Dozias, Dominique, Eggen, André, Elín Hreiðarsdóttir, Gunnfríður, Esquerré, Diane, Fouchet, Michel, Fouilloux, Marie-Noëlle, Fritz, Sébastien, Gallard, Yves, Graf, Alexander, Grohs, Cécile, Hoze, Chris, Journaux, Laurent, Klopp, Christophe, Krebs, Stefan, Le Bourhis, Daniel, Marchand, Jean-Luc, Marquant-Leguienne, Brigitte, Medugorac, Ivica, Pailhoux, Eric, Pannetier, Maëlle, Phocas, Florence, Ponsart, Claire, Reverse, Patrick, Rocha, Dominique, Rossignol, Marie-Noëlle, Rothammer, Sophie, Roy, Pierre, Russ, Ingolf, Salas-Cortes, Laura, Seichter, Doris, Soulas, Pascal, Thépot, Dominique, van Marle-Köster, Este, Venot, Eric, Wahlberg, Per, Weiss, Bernard   +48 more
core   +7 more sources

Relaxin family peptide receptors Rxfp1 and Rxfp2: mapping of the mRNA and protein distribution in the reproductive tract of the male rat

Reproductive Biology and Endocrinology, 2007
Background Relaxin is the endogenous ligand of the G-protein coupled receptor RXFP1, previously known as LGR7. In humans relaxin can also activate, but with lower affinity, the closely related receptor for the insulin-like peptide from Leydig cells ...
Porto Catarina S, Avellar Maria CW, Queiróz Daniel BC, Pimenta Maristela T, Cardoso Laís C, Filonzi Marcelo, Lazari Maria FM   +6 more
doaj   +1 more source

Chitosan and its derivatives as nanocarriers for siRNA delivery [PDF]

, 2012
The ability to specifically silence genes using siRNA has enormous potential for treating genetic diseases. However, siRNA instability and biodistribution issues still need to be overcome, and adequate delivery vehicles have proven indispensable in ...
Agnihotri, Alves, Amidi, Andersen, Aneja, Baker, Bernkop-Schnürch, Blau, Borchard, Bragonzi, Cai, Cheong, Choi, de la Fuente, de Martimprey, de Martimprey, Dehousse, Dehousse, Dreyer, Duan, Duceppe, El-Sharif, Fattal, Fattal, Feng, Fire, Fyrberg, Gao, Gary, Ghosn, Glud, Guo, Haasnoot, Han, Han, Hassani, Hess, Hirano, Howard, Howard, Huang, Huang, Huh, Hwang, Issa, Jeong, Jere, Ji, Jiang, Juliano, Katas, Katas, Kedmi, Kiang, Kim, Kim, Kim, Kim, Kong, Krebs, Köping-Höggård, Lai, Lam, Laroui, Lee, Lee, Lehr, Leng, Liao, Liu, Malhotra, Maslov, Meng, Meng, Mittnacht, Moreira, Mumper, Nawroth, Nielsen, Nishimura, Noh, Oh, Pardridge, Park, Park, Pavan, Pillé, Prabaharan, Pushparaj, Rahbek, Raviña, Rojanarata, Rudzinski, Salva, Saranya, Singh, Sioud, Strand, Tahara, Tahara, Tan, Tarapore, Techaarpornkul, Tokatlian, Uchida, Valentine, Varkouhi, Varkouhi, Varshosaz, Veiseh, Verheul, Walton, Wang, Wang, Wesche-Soldato, Xu, Yang, Ye, Yuan, Yuan, Yuan, Zhang, Zhang, Zhang   +123 more
core   +1 more source

Changes in Knee Laxity and Relaxin Receptor Isoforms Expression (RXFP1/RXFP2) in the Knee throughout Estrous Cycle Phases in Rodents. [PDF]

PLoS ONE, 2016
The changes in knee laxity and relaxin receptor expression at different phases of rodent estrous cycle are not known. Here, changes in the parameter were investigated in rats at different phases of the estrous cycle. Estrous cycle phases of intact female
Firouzeh Dehghan, Rahman Soori, Parvin Dehghan, Khadijeh Gholami, Sekaran Muniandy, Mohammad Ali Azarbayjani, Ashril Yusof   +6 more
doaj   +1 more source

Suppression of relaxin receptor RXFP1 decreases prostate cancer growth and metastasis [PDF]

Endocrine-Related Cancer, 2010
Relaxin (RLN) is a small peptide hormone expressed in several cancers of reproductive and endocrine organs. Increased expression of RLN in prostate cancer correlates with aggressive cancer. RLN G-protein-coupled receptor (RLN family peptide receptor 1, RXFP1) is expressed in both androgen receptor (AR)-positive and -negative prostate cancers as well as
Shu, Feng, Irina U, Agoulnik, Anne, Truong, Zhen, Li, Chad J, Creighton, Elena M, Kaftanovskaya, Rhea, Pereira, Hee Dong, Han, Gabriel, Lopez-Berestein, Thomas, Klonisch, Michael M, Ittmann, Anil K, Sood, Alexander I, Agoulnik   +12 more
openaire   +2 more sources

Interactions between inflammatory signals and the progesterone receptor in regulating gene expression in pregnant human uterine myocytes [PDF]

, 2012
The absence of a fall in circulating progesterone levels has led to the concept that human labour is associated with ‘functional progesterone withdrawal’ caused through changes in the expression or function of progesterone receptor (PR).
Barton, Geraint, Bennett, Phillip R., Brosens, Jan J., Christian, Mark, Huhtinen, Kaisa, Johnson, Mark R., Lee, Yun, Poutanen, Matti, Sooranna, Suren R., Terzidou, Vasso   +9 more
core   +2 more sources

Relaxin-Family Peptide Receptors 1 and 2 Are Fully Functional in the Bovine

Frontiers in Physiology, 2017
In most mammals the peptide hormone relaxin is a key physiological component regulating early pregnancy and birth. However, synteny analysis shows that the gene encoding ovarian relaxin-2 is deleted in cows and sheep.
Yanzhenzi Dai, Yanzhenzi Dai, Richard Ivell, Richard Ivell, Richard Ivell, Xuan Liu, Dana Janowski, Ravinder Anand-Ivell, Ravinder Anand-Ivell   +8 more
doaj   +1 more source