Results 71 to 80 of about 2,484 (221)
Single-cell transcriptomics uncovers distinct molecular signatures of stem cells in chronic myeloid leukemia [PDF]
, 2017 Recent advances in single-cell transcriptomics are ideally placed to unravel intratumoral heterogeneity and selective resistance of cancer stem cell (SC) subpopulations to molecularly targeted cancer therapies. However, current single-cell RNA-sequencing
Anderson, K +19 more
core +2 more sources
C1q/TNF‐related peptide 8 (CTRP8) promotes temozolomide resistance in human glioblastoma
Molecular Oncology, 2018 The C1q/TNF‐related peptide 8 (CTRP8) has recently emerged as a novel ligand of the G protein‐coupled receptor RXFP1 in the fatal brain tumor glioblastoma (GBM). We previously demonstrated that the CTRP8‐RXFP1 ligand–receptor system promotes motility and
Thatchawan Thanasupawat +8 more
doaj +1 more source
Frontiers in Endocrinology, 2013 Relaxin family peptide (RXFP) receptors 1 and 2 are unique G-protein coupled receptors in that they contain an N-terminal low density lipoprotein type A (LDLa) module which is necessary for receptor activation.
Shoni eBruell +14 more
doaj +1 more source
Disturbed relaxin signaling pathway and testicular dysfunction in mouse offspring upon maternal exposure to simazine. [PDF]
PLoS ONE, 2012 Simazine is a triazine herbicide that is being widely applied worldwide and commonly detected in surface and groundwater. Despite its popular use in controlling weeds and algae, very limited information is available regarding its toxicity. In the present
Ho-Oak Park, Jeehyeon Bae
doaj +1 more source
Frontiers in Physiology, 2022 Mammalian relaxin (RLN) family peptides binding their receptors (RXFPs) play a variety of roles in many physiological processes, such as reproduction, stress, appetite regulation, and energy balance.
Can Lv +13 more
doaj +1 more source
Unique transcriptomic landscapes identified in idiopathic spontaneous and infection related preterm births compared to normal term births. [PDF]
, 2019 Preterm birth (PTB) is leading contributor to infant death in the United States and globally, yet the underlying mechanistic causes are not well understood.
Ackerman, William E +6 more
core +3 more sources
In search of a small molecule agonist of the relaxin receptor RXFP1 for the treatment of liver fibrosis [PDF]
Scientific Reports, 2017 AbstractThe peptide hormone human relaxin-2 (H2-RLX) has emerged as a potential therapy for cardiovascular and fibrotic diseases, but its short in vivo half-life is an obstacle to long-term administration. The discovery of ML290 demonstrated that it is possible to identify small molecule agonists of the cognate G-protein coupled receptor for H2-RLX ...
Andrew McBride +14 more
openalex +5 more sources
Pathology and Oncology Research, 2022 Purpose: Lung adenocarcinoma is one of the most common malignancies. Though some historic breakthroughs have been made in lung adenocarcinoma, its molecular mechanisms of development remain elusive.
Yuning Xie +8 more
doaj +1 more source
Insulin-like Growth Factor 1 Analogs Clicked in the C Domain : Chemical Synthesis and Biological Activities [PDF]
, 2017 Human insulin-like growth factor 1 (IGF-1) is a 70 amino acid protein hormone, with key impact on growth, development, and lifespan. The physiological and clinical importance of IGF-1 prompted challenging chemical and biological trials toward the ...
Andrzej M. Brzozowski +11 more
core +2 more sources
Transcriptional regulation of human NMNAT2: insights from 3D genome sequencing and bioinformatics
The FEBS Journal, Volume 293, Issue 5, Page 1433-1458, March 2026.NMNAT2 is a valuable drug target, as low levels increase the risk of neurodegeneration. We employed 4C‐seq to identify NMNAT2 regulatory regions in the human genome, revealing distinct interactomes of the NMNAT2 promoter in undifferentiated and neuron‐like SH‐SY5Y cells. Additionally, we uncovered NMNAT2‐associated genes and transcription factors. This
Yu Chen Chang +5 more
wiley +1 more source