Results 71 to 80 of about 1,276 (166)

Expression and function of G-protein-coupled receptorsin the male reproductive tract

Anais da Academia Brasileira de Ciências, 2009
This review focuses on the expression and function of muscarinic acetylcholine receptors (mAChRs), α1-adrenoceptors and relaxin receptors in the male reproductive tract.
Maria Christina W. Avellar, Maria Fatima M. Lázari, Catarina S. Porto   +2 more
doaj   +1 more source

In vitro effects of relaxin on gene expression in porcine cumulus-oocyte complexes and developing embryos

Reproductive Biology and Endocrinology, 2011
Background Relaxin hormone peptide is found in porcine follicular and utero-tubal fluids, but its possible actions during early embryo development are still undetermined.
Willard Scott T, Greene Jonathan M, Feugang Jean M, Ryan Peter L   +3 more
doaj   +1 more source

Constitutive formation of an RXFP1‐signalosome: a novel paradigm in GPCR function and regulation [PDF]

British Journal of Pharmacology, 2012
The classical second messenger cAMP is important in diverse physiological processes, where its spatial and temporal compartmentalization allows precise control over multiple cellular events. Within this context, G‐protein‐coupled receptors (GPCRs) govern specialized pools of cAMP, which are functionally specific for the unique cellular effects ...
openaire   +2 more sources

#1437 Renal expression pattern of the relaxin receptor, RXFP1, and effects of the RXFP1 agonist, AZD5462, on renin in non-human primates and humans

Nephrology Dialysis Transplantation
Abstract Background and Aims RXFP1 is a G protein-coupled receptor (GPCR) for the pregnancy hormone, relaxin. While preclinical studies, performed primarily in rodent, describe beneficial effects of this pleiotropic peptide across several organ systems, there has been a disappointing lack of success ...
Mark Lal, Erik Ryberg, Magnus Althage, Fredrik Bergström, Pernille B L Hansen, Daniel Pettersen, Kat Connolly, Jaya Rosenmeier   +7 more
openaire   +1 more source

Emerging roles for the RXFP1 in myeloid series leukemia

International Journal of Medical Science and Clinical Invention
Purpose: The study investigates the role of Relaxin Family Peptide Receptor 1 (RXFP1) in myeloid leukemia cell function. It found that RXFP1 has been associated with cAMP, PI3K/Akt, NO/cGMP, MAPK and ERK1/2 signaling. High RXFP1 expression was associated with shorter cancer-specific survival RXFP1 mutated leukemia patients.
Ayriana Safari Baesmat, Berna Bayrakdar
openaire   +1 more source

Novel Relaxin Receptor RXFP1 Agonist AZD3427 in the Treatment of Heart Failure: A Phase 1a/b, First‐in‐Human, Randomized, Single‐Blind, Placebo‐Controlled Study

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Heart failure mortality remains high despite recent progress in pharmacological treatment. AZD3427 is a selective long‐acting analog of relaxin, a vasodilatory hormone with antifibrotic effects.
Kathleen Connolly, Richard George, Sami Omar, Elin Matsson, Magnus Åstrand, Magnus Althage, Daniel Pettersen, Esha Mohamed, Kelly Fang, Joao A. C. Lima, Mirjana Kujacic, Helena Ödesjö, Michelle Turton, Petra Johannesson, Anders Gabrielsen, Marcin Ufnal   +15 more
doaj   +1 more source

The complex binding mode of the peptide hormone H2 relaxin to its receptor RXFP1

Nature Communications, 2016
The mechanism by which relaxin activates the relaxin family peptide receptor-1 is poorly understood. Here, Sethi et al.identify a relaxin binding site in an extracellular linker between the LDLa and LRR domains and propose that relaxin binding stabilizes
Ashish Sethi, Shoni Bruell, Nitin Patil, Mohammed Akhter Hossain, Daniel J. Scott, Emma J. Petrie, Ross A. D. Bathgate, Paul R. Gooley   +7 more
doaj   +1 more source

Chemical synthesis of H2 relaxin analogue carrying an affinity tag through click chemistry-assisted diaminodiacid strategy

Results in Chemistry
H2 relaxin is an important member of the insulin superfamily, but little is known about how H2-relaxin activates the RXFP1 receptor. Affinity-tag containing peptide probes could separate receptor from cell/tissue lysate through pull-down methods, and the
Yuan Gao, Junjiang Li, Xiaona Han, Ning Wang, Jun Wang, Yi-Ming Li   +5 more
doaj   +1 more source

Identification and Characterization of a Distal Enhancer in RXFP1 Gene [PDF]

A62. LUNG FIBROSIS: INSIGHTS FROM THE BENCH, 2020
T.-Y. Chen, J. Tan, X. Li, C.-H. Hung, D. Totten, T.-K. Hung, H. Bahudhanapati, D. Kass, Y. Zhang   +8 more
openaire   +1 more source

Transcriptomic analysis of the HPT axis in a model of oligoasthenozoospermia induced by Adenine in rats

Experimental and Molecular Pathology
Male infertility is most commonly caused by oligozoospermia, and its pathogenesis is still poorly understood at the molecular level. This study used RNA sequencing (RNA-Seq) technology to identify candidate genes and regulatory pathways that regulate ...
Nan Yang, Xiao-ge Wei, Kaiying Li, Fei Wang, Fei Song, Wenjing Sun, Yan Wang, Zhenning Zhao, Jing Mu, Huisheng Ma   +9 more
doaj   +1 more source