Results 51 to 60 of about 2,484 (221)

The O-carbamoyl-transferase albis is responsible for the modification of albicidin [PDF]

, 2016
Albicidin is a potent antibiotic and phytotoxin produced by the sugarcane pathogenic bacterium Xanthomonas albilineans which targets the plant and bacterial DNA gyrase.[1] The infection occurs through the xylem vessels of the plants where the pathogen ...
Arasté, Julie, Cociancich, Stéphane, Hempel, Benjamin, Kerwat, Dennis, Marguerettaz, Mélanie, Pesic, Alexander, Petras, Daniel, Royer, Monique, Semsary, Siamak, Süssmuth, Roderich, Von Eckardstein, Leonard   +10 more
core   +1 more source

A novel role for relaxin-2 in the pathogenesis of primary varicosis. [PDF]

PLoS ONE, 2012
BACKGROUND: Varicose veins affect up to 40% of men and up to 51% of women. The pathophysiology of primary varicosis is poorly understood. Theories ranging from incompetence of the venous valves to structural changes in the vein wall have been proposed ...
Julia Adams, Sarah Schott, Arno Bern, Matthias Renz, Kristian Ikenberg, Claus Garbe, Christian Busch   +6 more
doaj   +1 more source

Synthesis of fluorescent analogues of relaxin family peptides and their preliminary in vitro and in vivo characterization

Frontiers in Chemistry, 2013
Relaxin, a heterodimeric polypeptide hormone, is a key regulator of collagen metabolism and multiple vascular control pathways in humans and rodents.
Linda eChan, Linda eChan, Craig eSmith, Craig eSmith, Berenice eChua, Feng eLin, Ross eBathgate, Ross eBathgate, Ross eBathgate, Frances eSeparovic, Andrew eGundlach, Andrew eGundlach, M. Akhter eHossain, M. Akhter eHossain, M. Akhter eHossain, John eWade, John eWade, John eWade   +17 more
doaj   +1 more source

Mesangial Cells Cultured from Pregnant Rats Display Reduced Reactivity to Angiotensin II: the Role of Relaxin, Nitric Oxide and AT2 Receptor [PDF]

, 2012
Background/Aims: Pregnancy is characterized by vasodilatation and increased glomerular filtration rate (GFR), despite overstimulation of the renin angiotensin system (RAS).
Boim, Mirian Aparecida, Carvalho, Lucimeire Nova de, Cristovam, Priscila Cardoso, Passos, Clévia dos Santos   +3 more
core   +1 more source

Regulation of the reproductive cycle and early pregnancy by relaxin family peptides [PDF]

, 2014
The relaxin family of peptide hormones are structurally closely related to one another sharing a heterodimeric A–B structure, like that of insulin. They may also be active as unprocessed B–C–A pro-forms.
Adham, Amory, Anand-Ivell, Anand-Ivell, Anand-Ivell, Anand-Ivell, Anumba, Arroyo, Balvers, Bamberger, Bartsch, Bartsch, Bathgate, Bathgate, Bathgate, Bell, Blankenship, Bogatcheva, Braun, Brännström, Burnicka-Turek, Burnicka-Turek, Büllesbach, Conrad, Einspanier, Einspanier, Ferlin, Ferlin, Feugang, Feugang, Gambineri, Gellersen, Ghattas, Glister, Goldsmith, Granot, Guo, Halls, Halls, Hanna, Hansell, Havelock, Hayes, Heng, Hossain, Hsu, Hughes, Hwang, Irving-Rodgers, Ivell, Ivell, Ivell, Ivell, Ivell, Ivell, Jauniaux, Johnson, Kamat, Kawamura, Kim, Klonisch, Laurent, Lok, Luu, MacLennan, Maseelall, McGowan, McGuane, McMillen, Millar, Minagawa, Mita, Monk, Nef, Nguyen, Ohleth, Parry, Piccinni, Piccinni, Pusch, Ramathal, Ravinder Anand-Ivell, Richard Ivell, Rogers, Satchell, Segal, Sherwood, Shirota, Shirota, Silvertown, Siqin, Smith, Spanel-Borowski, Stewart, Stewart, Tang, Unemori, Unemori, Van Hiel, Vandevoort, Wathes, Wilson, Zimmermann   +102 more
core   +1 more source

The Discoveryof C7-Substituted Norbornyl Bisamidesas RXFP1 Small Molecule Agonists

Journal of Medicinal Chemistry
Human relaxin-2 (relaxin, H2-RLX, RLN2), an endogenous hormone associated with mammalian pregnancy, and its cognate receptor relaxin family peptide receptor 1 (RXFP1) have been implicated as important modulators of cardiovascular function and agonism of RXFP1 may potentially be utilized for the treatment of heart failure.
Shun Su (1341414), Michael C. Myers (243226), Donna M. Bilder (1834252), Adam Clarke (6933956), Todd Friends (21438331), Thomas V. Petrone (21438334), Carol Ryan (8436033), Carol M. Krause (1399357), Ruihua Chen (601853), Yi-xin Li (21214235), Matthew Fronheiser (15027146), Michael A. Galella (2065051), Anne V. Rose (1622320), Claudia N. Generaux (11596149), Lei Zhao (144153), Jeff Bostwick (21438337), Jianqing Li (523126), Arvind Mathur (144120), Franck Duclos (451361), Cort S. Madsen (21438340), Ruth R. Wexler (1550446), R. Michael Lawrence (2065054)   +21 more
  +5 more sources

The G protein-coupled receptor heterodimer network (GPCR-HetNet) and its hub components [PDF]

, 2014
G protein-coupled receptors (GPCRs) oligomerization has emerged as a vital characteristic of receptor structure. Substantial experimental evidence supports the existence of GPCR-GPCR interactions in a coordinated and cooperative manner.
Agnati, Luigi F, Borroto-Escuela, Dasiel O, Brito, Ismel, Di Palma, Michael, Duchou, Jolien, Fuxe, Kjell, Guidolin, Diego, Oflijan, Julia, Rivera, Alicia, Romero-Fernandez, Wilber, Skieterska, Kamila, Suárez-Boomgaard, Diana, Van Craenenbroeck, Kathleen   +12 more
core   +4 more sources

Male seminal relaxin contributes to induction of the post-mating cytokine response in the female mouse uterus [PDF]

, 2017
The hormone relaxin is important in female reproduction for embryo implantation, cardiovascular function, and during labor and lactation. Relaxin is also synthesized in males by organs of the male tract.
Almeida, Anand-Ivell, Anand-Ivell, Bartsch, Bartsch, Bathgate, Brannström, Bromfield, Bryant-Greenwood, Carrell, Conrad, Downing, Einspanier, Esche, Ferlin, Feugang, Figueiredo, Ganesan, Goldsmith, Gunnersen, Heng, Horton, Horton, Ivell, Ivell, Johansson, Kachkache, Kohsaka, Laird, Lee, MacLennan, McMaster, Miah, Millar, Moldenhauer, Muller, Orsi, Parry, Parsell, Piccinni, Piccinni, Pillai, Plaks, Ponikowski, Robertson, Robertson, Robertson, Robertson, Robertson, Robertson, Robertson, Robertson, Rodríguez-Martínez Kvist, Rogers, Samuel, Samuel, Schjenken, Scott, Sharkey, Sharkey, Sherwood, Siebel, Snell, Stults, Taylor, Wira, Wood, Zhao   +67 more
core   +2 more sources

Expansion of specialized epidermis induced by hormonal state and mechanical strain [PDF]

, 2015
In mammals, some sites of specialized skin such as the palms, soles, and lips grow proportionally with the animal. However, other types of specialized skin such as the nipple and anal/genital region are dramatically altered with changes of reproductive ...
Easwaran, Teresa, Elgar, Richard Levi, Foley, John, Koyama, Sachiko, Offutt, Carlos D., Spandau, Dan F., Wu, Hsin-Jung   +6 more
core   +1 more source

Sphingosine 1-phosphate receptors: do they have a therapeutic potential in cardiac fibrosis? [PDF]

, 2017
Sphingosine 1-phosphate (S1P) is a bioactive lipid that is characterized by a peculiar mechanism of action. In fact, S1P, which is produced inside the cell, can act as an intracellular mediator, whereas after its export outside the cell, it can act as ...
Frati, Alessia, Meacci, Elisabetta, Monaco, Lucia, Pierucci, Federica, Vestri, Ambra   +4 more
core   +2 more sources