Results 81 to 90 of about 2,484 (221)
Examination of relaxin and its receptors expression in pig gametes and embryos
Reproductive Biology and Endocrinology, 2011 Background Relaxin is a small peptide also known as pregnancy hormone in many mammals. It is synthesized by both male and female tissues, and its secretions are found in various body fluids such as plasma serum, ovarian follicular fluid, utero-oviduct ...
Bathgate Ross A +4 more
doaj +1 more source
Luteal and hypophyseal expression of the canine relaxin (RLN) system during pregnancy: Implications for luteotropic function. [PDF]
PLoS ONE, 2018 By acting through its receptors (RXFP1, RXFP2), relaxin (RLN) exerts species-specific effects during pregnancy; possible luteotropic effects through stimulation of prolactin (PRL) release have been suggested.
Marta Nowak +2 more
doaj +1 more source
Transcriptional up-regulation of relaxin-3 by Nur77 attenuates β-adrenergic agonist-induced apoptosis in cardiomyocytes. [PDF]
, 2018 The relaxin family peptides have been shown to exert several beneficial effects on the heart, including anti-apoptosis, anti-fibrosis, and anti-hypertrophy activity.
Cheng, Fang +10 more
core +1 more source
Central relaxin-3 receptor (RXFP3) activation increases ERK phosphorylation in septal cholinergic neurons and impairs spatial working memory. [PDF]
, 2016 The medial septum/diagonal band (MS/DB) is a relay region connecting the hypothalamus and brainstem with the hippocampus, and both the MS/DB and dorsal/ventral hippocampus receive strong topographic GABA/peptidergic projections from the nucleus incertus ...
Albert Gasco, Hector +6 more
core +2 more sources
Advanced Science, Volume 13, Issue 1, 5 January 2026.Single‐nucleus RNA sequencing of mid‐gestation brains from fetuses with nonsyndromic cleft lip and palate reveals major disruptions in cell composition, cell‐to‐cell signaling, and gene regulation. The transcription factor MEF2C is identified as a central regulator of these changes and shows that lowering MEF2C impairs synapse formation, linking cleft ...
Liu‐Lin Xiong +19 more
wiley +1 more source
The Different Ligand-Binding Modes of Relaxin Family Peptide Receptors RXFP1 and RXFP2 [PDF]
Molecular Endocrinology, 2012 Relaxin and insulin-like peptide 3 (INSL3) are peptide hormones with a number of important physiological roles in reproduction, regulation of extracellular matrix turnover, and cardiovascular function. Relaxin and INSL3 mediate their actions through the closely related G-protein coupled receptors, relaxin family peptide receptors 1 and 2 (RXFP1 and ...
Scott, Daniel J. +2 more
openaire +5 more sources
Allergy, Volume 81, Issue 1, Page 170-184, January 2026.This study investigates airway remodeling in acute and chronic experimental asthma models induced by house dust mite extract to elucidate inflammatory and structural changes. Two acute T2‐low models demonstrated pronounced airway inflammation characterized by goblet cell hyperplasia, collagen deposition, and significant upregulation of extracellular ...
Marlena Tynecka +17 more
wiley +1 more source
Insulin-like factor 3 and the HPG axis in the male [PDF]
, 2014 The hypothalamic–pituitary–gonadal (HPG) axis comprises pulsatile GnRH from the hypothalamus impacting on the anterior pituitary to induce expression and release of both LH and FSH into the circulation.
Anand-Ivell, Ravinder +2 more
core +3 more sources
BMC Urology, 2020 Background Relaxin is an endogenous protein that has been shown to have antifibrotic properties in various organ systems. There has been no characterization of relaxin’s role in the human bladder.
Edward C. Diaz +7 more
doaj +1 more source
New perspectives in signaling mediated by receptors coupled to stimulatory G protein: the emerging significance of cAMP efflux and extracellular cAMP-adenosine pathway [PDF]
, 2015 G protein coupled receptors (GPCRs) linked to stimulatory G (Gs) proteins (GsPCRs) mediate increases in intracellular cyclic AMP as consequence of activation of nine adenylyl cyclases, which differ considerably in their cellular distribution and ...
Duarte, Thiago +2 more
core +2 more sources