Results 101 to 110 of about 2,484 (221)

Early Onset Memory Deficit of WMI Rats Compared to Their Nearly Isogenic WLIs Is Reversed by Enriched Environment in Females

Genes, Brain and Behavior, Volume 24, Issue 3, June 2025.
Enriched environment housing reverses memory deficits in middle‐aged WMI females and attenuates deficits in WMI males. Plasma levels of estradiol and hippocampal gene expression followed the same pattern as memory in WMI females following environmental enrichment and may be involved in reversing the effects of aging on cognitive decline.
Michelle T. Ji, Katherine J. Przybyl, Aspen M. Harter, Mariya Nemesh, Sophia T. Jenz, Anna Yamazaki, Chris Kim, Megan K. Mulligan, Hao Chen, Eva E. Redei   +9 more
wiley   +1 more source

Robust Spatial Cell‐Type Deconvolution with Qualitative Reference for Spatial Transcriptomics

Small Methods, Volume 9, Issue 5, May 17, 2025.
QR‐SIDE is a robust method to integrate cell‐type deconvolution and domain detection for spatial transcriptomics. By leveraging marker genes and spatial information, it uncovers tissue architecture and cell‐type compositions. Its adaptive modeling ensures resilience to noisy markers, and its flexibility supports applications across resolutions ...
Qishi Dong, Yi Yang, Ziye Luo, Haipeng Shen, Xingjie Shi, Jin Liu   +5 more
wiley   +1 more source

The transcription factor GTF2IRD1 regulates the topology and function of photoreceptors by modulating photoreceptor gene expression across the retina [PDF]

, 2014
The mechanisms that specify photoreceptor cell-fate determination, especially as regards to short-wave-sensitive (S) versus medium-wave-sensitive (M) cone identity, and maintain their nature and function, are not fully understood.
Berlinicke, Cindy, Bush, Ronald, Chen, Shiming, Conner, Elizabeth A, Kjellstrom, Sten, Masuda, Tomohiro, Swaroop, Anand, Thorgeirsson, Snorri S, Wan, Jun, Yerrabelli, Anitha, Zack, Donald J, Zhang, Xiaodong   +11 more
core   +2 more sources

Therapeutic and Prognostic Potential of G Protein‐Coupled Receptors in Lung Adenocarcinoma: Evidence From Transcriptome Data and In Vitro Experiments

The Clinical Respiratory Journal, Volume 19, Issue 5, May 2025.
This integrated analysis demonstrates the involvements of G protein‐coupled receptors (GPCRs) in lung adenocarcinoma developments and proves the potential of five key GPCRs as prognostic biomarkers and targets in lung adenocarcinoma. ABSTRACT Background G protein‐coupled receptors (GPCRs), the largest family of cell‐surface molecules involve in various
Feiyan Yang, Jianye Yang, Guobiao Yang, Ya Zhang   +3 more
wiley   +1 more source

Utilization of Bulk RNA Sequencing for the Evaluation of Keratin Nanomaterials as a Coating for Percutaneous Devices

Journal of Biomedical Materials Research Part B: Applied Biomaterials, Volume 113, Issue 3, March 2025.
ABSTRACT Despite advances in the design and protocols for maintaining the skin/device interface around percutaneous devices (PDs), no current strategy ensures the permanent attachment of peri‐implant epithelial tissue to the device surface. Based on preliminary data, we hypothesized that PDs coated with keratin nanomaterials, resembling the fingernail ...
Andrew Miller, James Peter Beck, Alexis White, Jayant Agarwal, Kent N. Bachus, Sujee Jeyapalina, Mark Van Dyke   +6 more
wiley   +1 more source

Comparative Distribution of Relaxin-3 Inputs and Calcium-Binding Protein-Positive Neurons in Rat Amygdala [PDF]

, 2016
The neural circuits involved in mediating complex behaviors are being rapidly elucidated using various newly developed and powerful anatomical and molecular techniques, providing insights into the neural basis for anxiety disorders, depression, addiction,
Ana M Sanchez-perez, Andrew L Gundlach, Andrew L Gundlach, Celia W Pereira, Fabio N Santos, Francisco E Olucha-Bordonau, Marcos eOtero, Sherie K Ma   +7 more
core   +2 more sources

Targeting Fibrosis: From Molecular Mechanisms to Advanced Therapies

Advanced Science, Volume 12, Issue 3, January 20, 2025.
This review comprehensively summarizes the advances in research for fibrosis. It emphasizes organ‐specific profibrotic cell types and molecular mechanisms of fibrosis, especially in the kidney, liver, lung, and heart. The authors highlight the advanced antifibrotic small molecule drugs and cellular therapies for fibrosis.
Xingpeng Di, Ya Li, Jingwen Wei, Tianyue Li, Banghua Liao   +4 more
wiley   +1 more source

A de novo evolved gene in the house mouse regulates female pregnancy cycles

, 2019
The de novo emergence of new genes has been well documented through genomic analyses. However, a functional analysis, especially of very young protein-coding genes, is still largely lacking.
Bekpen, C., Keshavarz, M., Krebs-Wheaton, R., Künzel, S., Skrabar, N., Tautz, D., Ullrich, K., Xie, C.   +7 more
core   +1 more source

Identification of key residues essential for the structural fold and receptor selectivity within the A-chain of human gene-2 (H2) relaxin [PDF]

, 2012
Human gene-2 (H2) relaxin is currently in Phase III clinical trials for the treatment of acute heart failure. It is a 53-amino acid insulin-like peptide comprising two chains and three disulfide bonds. It interacts with two of the relaxin family peptide (
Akhter Hossain, Bathgate, Bathgate, Bathgate, Brooks, Bryant-Greenwood, Büllesbach, Büllesbach, Büllesbach, Chan, Chen, Du, Hahn, Hartley, Haugaard-Kedström, Heeg, Hewitson, Hossain, Hossain, Hossain, Hossain, Hossain, Hossain, Hsu, Huang, Keller, Kong, Kumagai, Liu, Liu, Park, Rosengren, Rosengren, Samuel, Samuel, Samuel, Samuel, Scott, Scott, Scott, Shabanpoor, Shabanpoor, Sudo, Teerlink, Unemori, Whittaker, Wishart, Wüthrich, Zhang   +48 more
core   +1 more source

Hormone receptor expression in human fascial tissue

European Journal of Histochemistry, 2016
Many epidemiologic, clinical, and experimental findings point to sex differences in myofascial pain in view of the fact that adult women tend to have more myofascial problems with respect to men. It is possible that one of the stimuli to sensitization of
C. Fede, G. Albertin, L. Petrelli, M.M. Sfriso, C. Biz, R. De Caro, C. Stecco   +6 more
doaj   +1 more source