Results 111 to 120 of about 2,484 (221)

Glucagon-Like Peptide-1 Excites Firing and Increases GABAergic Miniature Postsynaptic Currents (mPSCs) in Gonadotropin-Releasing Hormone (GnRH) Neurons of the Male Mice via Activation of Nitric Oxide (NO) and Suppression of Endocannabinoid Signaling Pathways [PDF]

, 2016
Glucagon-like peptide-1 (GLP-1), a metabolic signal molecule, regulates reproduction, although, the involved molecular mechanisms have not been elucidated, yet.
Csaba Fekete, Csaba Vastagh, Erik Hrabovszky, Erzsébet Farkas, Flóra Bálint, Imre Farkas, Katalin Skrapits, Zsolt Liposits   +7 more
core   +1 more source

Functional crosstalk between angiotensin receptors (types 1 and 2) and relaxin family peptide receptor 1 (RXFP1): Implications for the therapeutic targeting of fibrosis

British Journal of Pharmacology, Volume 181, Issue 14, Page 2302-2318, July 2024.
Class A, rhodopsin‐like, G‐protein‐coupled receptors (GPCRs) are by far the largest class of GPCRs and are integral membrane proteins used by various cells to convert extracellular signals into intracellular responses. Initially, class A GPCRs were believed to function as monomers, but a growing body of evidence has emerged to suggest that these ...
Chrishan S. Samuel, Yifang Li, Yan Wang, Robert E. Widdop   +3 more
wiley   +1 more source

Population Genetic Analysis of Ten Geographically Isolated Tibetan Pig Populations

Animals, 2020
Several geographically isolated populations of Tibetan pigs inhabit the high-altitude environment of the Tibetan Plateau. Their genetic relationships, contribution to the pool of genetic diversity, and their origin of domestication are unclear.
Peng Shang, Wenting Li, Zhankun Tan, Jian Zhang, Shixiong Dong, Kejun Wang, Yangzom Chamba   +6 more
doaj   +1 more source

Targeting G protein‐coupled receptors for heart failure treatment

British Journal of Pharmacology, Volume 181, Issue 14, Page 2270-2286, July 2024.
Heart failure remains a leading cause of morbidity and mortality worldwide. Current treatment for patients with heart failure include drugs targeting G protein‐coupled receptors such as β‐adrenoceptor antagonists (β‐blockers) and angiotensin II type 1 receptor antagonists (or angiotensin II receptor blockers).
Bui San Thai, Ling Yeong Chia, Anh T. N. Nguyen, Chengxue Qin, Rebecca H. Ritchie, Dana S. Hutchinson, Andrew Kompa, Paul J. White, Lauren T. May   +8 more
wiley   +1 more source

Total Chemical Synthesis of Aggregation‐Prone Disulfide‐Rich Starfish Peptides

Chemistry – A European Journal, Volume 30, Issue 33, June 12, 2024.
This work presents a comprehensive synthetic strategy for creating relaxin‐like peptides characterized by a two‐chain structure linked by three disulfide bonds. Utilizing Fmoc solid‐phase peptide synthesis, the A‐ and B‐chains are independently assembled with orthogonal cysteine protecting groups (tBu, Acm, Trt) to facilitate the controlled formation ...
Hongkang Wu, Praveen Praveen, Thomas N. G. Handley, Chaitra Chandrashekar, Scott F. Cummins, Ross A. D. Bathgate, Mohammed Akhter Hossain   +6 more
wiley   +1 more source

Comprehensive analysis of lncRNA‐associated ceRNA network reveals novel potential prognostic regulatory axes in glioblastoma multiforme

Journal of Cellular and Molecular Medicine, Volume 28, Issue 11, June 2024.
Abstract Deciphering the lncRNA‐associated competitive endogenous RNA (ceRNA) network is essential in decoding glioblastoma multiforme (GBM) pathogenesis by regulating miRNA availability and controlling mRNA stability. This study aimed to explore novel biomarkers for GBM by constructing a lncRNA‐miRNA‐mRNA network.
Maryam Bazrgar, Seyed Amir Mirmotalebisohi, Mohsen Ahmadi, Parisa Azimi, Leila Dargahi, Hakimeh Zali, Abolhassan Ahmadiani   +6 more
wiley   +1 more source

Relaxin family peptide receptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database [PDF]

, 2019
Relaxin family peptide receptors (RXFP, nomenclature as agreed by the NC-IUPHAR Subcommittee on Relaxin family peptide receptors [18, 75]) may be divided into two pairs, RXFP1/2 and RXFP3/4.
Bathgate, Ross, Dschietzig, Thomas, Gundlach, Andrew L., Halls, Michelle, Summers, Roger   +4 more
core   +2 more sources

#1437 Renal expression pattern of the relaxin receptor, RXFP1, and effects of the RXFP1 agonist, AZD5462, on renin in non-human primates and humans

Nephrology Dialysis Transplantation
Abstract Background and Aims RXFP1 is a G protein-coupled receptor (GPCR) for the pregnancy hormone, relaxin. While preclinical studies, performed primarily in rodent, describe beneficial effects of this pleiotropic peptide across several organ systems, there has been a disappointing lack of success ...
Mark Lal, Erik Ryberg, Magnus Althage, Fredrik Bergström, Pernille B L Hansen, Daniel Pettersen, Kat Connolly, Jaya Rosenmeier   +7 more
openaire   +1 more source

In vitro effects of relaxin on gene expression in porcine cumulus-oocyte complexes and developing embryos

Reproductive Biology and Endocrinology, 2011
Background Relaxin hormone peptide is found in porcine follicular and utero-tubal fluids, but its possible actions during early embryo development are still undetermined.
Willard Scott T, Greene Jonathan M, Feugang Jean M, Ryan Peter L   +3 more
doaj   +1 more source

Sustained microglial depletion with CSF1R inhibitor impairs parenchymal plaque development in an Alzheimer's disease model. [PDF]

, 2019
Many risk genes for the development of Alzheimer's disease (AD) are exclusively or highly expressed in myeloid cells. Microglia are dependent on colony-stimulating factor 1 receptor (CSF1R) signaling for their survival.
Bollag, Gideon, Broome, Stephanie, Burton, Elizabeth A, Crapser, Joshua, Green, Kim N, Habets, Gaston, Hohsfield, Lindsay A, Ibrahim, Prabha, Lin, Jack, Nespi, Marika, Phan, Nicole Y, Rymar, Andrey, Severson, Paul L, Singh, Parmveer, Spangenberg, Elizabeth, Spevak, Wayne, Tsang, Garson, Walters, Jason, West, Brian L, Zhang, Chao, Zhang, Jiazhong, Zhang, Ying   +21 more
core