Results 121 to 130 of about 1,276 (166)

RXFP1 expression is activated in the brains of humans with epilepsy.

openaire   +2 more sources

Essential function of Nr4a2 in subicular development and social novelty. [PDF]

J Adv Res
Liu XY, Tao YC, Zhang Q, Liu WT, Zhao L, Hu ZB, Zhou BY, Li ZX, Qi CC, Zhang L, Chen JY, Song NN, Ding YQ.   +12 more
europepmc   +1 more source

Neurobiology of the trigeminal ganglion in comparison to the dorsal root ganglion. [PDF]

Pain
Su S, Kim M, Liedtke W, Chen Y.
europepmc   +1 more source

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Emerging roles for the relaxin/RXFP1 system in cancer therapy

Molecular and Cellular Endocrinology, 2019
A role for the hormone relaxin in cancer was described well before the receptor was identified. Relaxin predominantly increases the growth and invasive potential in cancers of different origins. However, relaxin was also shown to promote cell differentiation and to act in a dose-and time-dependent manner in different cancer cell models used.
Sabine Hombach-Klonisch, Thomas Klonisch, Aleksandra Glogowska   +2 more
exaly   +3 more sources

RXFP1, the relaxin receptor: Lost and found in translation

Drug Discovery Today
Relaxin, historically recognized as a pregnancy hormone, is today characterized as a circulating protein possessing several cardiovascular modulating and anti-fibrotic properties of high clinical interest. Although it has long been recognized that there exists remarkable species diversity regarding the tissue sources and physiological effects of ...
Sean Eddy, Mark Lal, Jeffrey Hodgin
exaly   +3 more sources

Modeling the Primary Hormone-Binding Site of RXFP1 and RXFP2

Annals of the New York Academy of Sciences, 2009
The primary binding sites of the relaxin and insulin‐like peptide 3 (INSL3) receptors, RXFP1 and RXFP2, are found within the leucine‐rich repeats (LRRs) of the ectodomains. Specific B‐chain residues in the peptides interact with residues in the inner β‐sheets of the LRRs of the receptors.
Ross Bathgate, Daniel J. Scott, Geoffrey W Tregear   +2 more
exaly   +3 more sources

Development of human cells with RXFP1 knockdown using retroviral delivery of microRNA against human RXFP1

Italian Journal of Anatomy and Embryology, 2014
To study the specifi c actions of relaxin through RXFP1 in human cells, it would be advantageous to develop cell populations with permanent RXFP1 knockdown (KD). We have developed and assessed four microRNA against human RXFP1. One of the four designed microRNA displayed signifi cant RXFP1 KD as assessed by reduced relaxin binding when co-transfected ...
Yong, K.J., Callander, G.E., Bergin, R., Samuel, C.S., Bathgate, Ross A.D.   +4 more
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Relaxin Receptor LGR7 (RXFP1) Is Regulated by Estrogen

Annals of the New York Academy of Sciences, 2009
Estrogen regulates LGR7 (RXFP1) mRNA expression in an in vitro model of human term pregnancy cervix that utilizes lower uterine segment fibroblasts. LGR7 mRNA levels were increased by estradiol to mean levels of 152%± 5.9% above those in untreated control cells. Therefore, estradiol may amplify relaxin's actions in the cervix.
Priya, Maseelall, Jeff, Gardner, Andrea, Wojtczuk, Gerson, Weiss, Laura T, Goldsmith   +4 more
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Development of a scaffold displaying exoloops of RXFP1

Italian Journal of Anatomy and Embryology, 2014
Relaxin family peptide receptor 1 (RXFP1), the cognate receptor for relaxin, is a G-protein coupled receptor (GPCR) possessing a unique extracellular region consisting of a domain of 10 leucine rich repeats (LRRs) linked to an N-terminal low density lipoprotein Class A module.
Diepenhorst, Natalie A., Gooley, Paul R., Stone, Martin J., Bathgate, Ross A.D.   +3 more
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Proteomic and cytokine profiling of a CTRP8-RXFP1 glioma mouse model

Biochemical Pharmacology
Glioblastoma (GB) is the most prevalent and aggressive primary brain tumor with fatal outcome due to a lack of effective treatments. We previously identified C1q-tumor necrosis factor-related protein 8 (CTRP8), a new member of the adiponectin family, as a novel agonist of the relaxin family peptide receptor 1 (RXFP1) and showed that the CTRP8-RXFP1 ...
Aleksandra Glogowska, Thatchawan Thanasupawat, Farhana Begum   +2 more
exaly   +3 more sources