Identification of Small-Molecule Agonists of Human Relaxin Family Receptor 1 (RXFP1) by Using a Homogenous Cell-Based cAMP Assay [PDF]
, 2012 Catherine Z. Chen +10 more
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Frontiers of antifibrotic therapy in systemic sclerosis [PDF]
, 2017 Although fibrosis is becoming increasingly recognized as a major cause of morbidity and mortality in modern societies, targeted anti-fibrotic therapies are still not approved for most fibrotic disorders. However, intense research over the last decade has
Abraham, DJ +5 more
core
Structural insights into the modes of relaxin-binding and tethered-agonist activation of RXFP1 and RXFP2 [PDF]
, 2021 Ashish Sethi +14 more
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Relaxin Receptor RXFP1 and RXFP2 Expression in Ligament, Tendon, and Shoulder Joint Capsule of Rats
Journal of Korean Medical Science, 2016 Numerous musculoskeletal disorders are caused by thickened ligament, tendon stiffness, or fibrosis of joint capsule. Relaxin, a peptide hormone, can exert collagenolytic effect on ligamentous and fibrotic tissues. We hypothesized that local injection of relaxin could be used to treat entrapment neuropathy and adhesive capsulitis.
Jae Hyung Kim +4 more
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RXFP1 expression is regulated by miR-144-3p in Fibroblasts from Patients with Idiopathic Pulmonary Fibrosis [PDF]
, 2017 Harinath Bahudhanapati +5 more
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Fluorescence correlation spectroscopy, combined with bimolecular fluorescence complementation, reveals the effects of β-arrestin complexes and endocytic targeting on the membrane mobility of neuropeptide Y receptors [PDF]
, 2012 Fluorescence correlation spectroscopy (FCS) and photon counting histogram (PCH) analysis are powerful ways to study mobility and stoichiometry of G protein coupled receptor complexes, within microdomains of single living cells.
Briddon, Stephen J. +2 more
core
LncRNA NKILA integrates RXFP1/AKT and NF‐κB signalling to regulate osteogenesis of mesenchymal stem cells [PDF]
, 2019 Ying Zhang +8 more
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Results in ChemistryH2 relaxin is an important member of the insulin superfamily, but little is known about how H2-relaxin activates the RXFP1 receptor. Affinity-tag containing peptide probes could separate receptor from cell/tissue lysate through pull-down methods, and the
Yuan Gao +5 more
doaj +1 more source
Cardiomyocyte-specific RXFP1 overexpression protects against pressure overload-induced cardiac dysfunction independently of Relaxin [PDF]
Heart failure (HF) prevalence is rising due to reduced early mortality and demographic change. Relaxin (RLN) mediates protective effects in the cardiovascular system through Relaxin-receptor 1 (RXFP1).
de la Torre, C. +11 more
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PS2 - 209 RXFP1 Promotes Temozolomide Chemoresistance by STAT3 Signaling Pathway Activation [PDF]
, 2016 Thatchawan Thanasupawat +7 more
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