Results 131 to 140 of about 1,276 (166)
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Mechanisms of Relaxin Receptor (LGR7/RXFP1) Expression and Function
Annals of the New York Academy of Sciences, 2009The LGR7/RXFP1 and LGR8/RXFP2 receptors are unique receptors among the G‐protein‐coupled receptors (GPCRs) in having a low‐density lipoprotein class A (LDL‐A) module. Their complex gene organization, among the intron‐richest of the GPCRs, suggests that alternative splicing is a common occurrence.
András, Kern +1 more
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Expression of RXFP1 in skin of scleroderma patients and control subjects
Scandinavian Journal of Rheumatology, 2012Relaxin (RLX) is involved in extracellular matrix and collagen remodelling. The therapeutic role of the circulating isoform RLX-2 as an anti-fibrotic factor in systemic sclerosis (SSc) has been investigated. Several RLX family peptide receptors (RXFPs) are recognized in humans: RLX-2 is a ligand for RXFP1/LGR7 and RXFP2/LGR8.
Giordano, N. +14 more
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Resolving the Unconventional Mechanisms Underlying RXFP1 and RXFP2 Receptor Function
Annals of the New York Academy of Sciences, 2009The receptors for relaxin and insulin‐like peptide 3 (INSL3) are now well‐characterized as the relaxin family peptide (RXFP) receptors RXFP1 and RXFP2, respectively. They are G‐protein‐coupled receptors (GPCRs) with closest similarity to the glycoprotein hormone receptors, with both containing large ectodomains with 10 leucine‐rich repeats (LRRs ...
Ross Bathgate +2 more
exaly +3 more sources
Italian Journal of Anatomy and Embryology - contenuto non piu disponibile
Italian Journal of Anatomy and Embryology, Vol 118, No 1 (Supplement ...Yong, K.J. +4 more
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H3 Relaxin Demonstrates Antifibrotic Properties via the RXFP1 Receptor
Biochemistry, 2011Human gene 3 (H3) relaxin is the most recently discovered member of the relaxin peptide family and can potentially bind all of the defined relaxin family peptide receptors (RXFP1-4). While its effects as a neuromodulator are being increasingly studied through its primary receptor, RXFP3, its actions via other RXFPs are poorly understood.
Mohammed Akhter, Hossain +6 more
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Recombinant RXFP1-LDL-A module does not form dimers
Italian Journal of Anatomy and Embryology, 2014The Relaxin receptor, RXFP1, is a complex G-protein coupled receptor (GPCR). It has a rhodopsin- like 7 transmembrane helix region and a large ecto-domain containing Leucine-rich repeats and a Low Desnsity Lipoprotein Class-A module at the N-terminus. RXFP1 and the closely related receptor for INSL3, RXFP2 are the only mammalian GPCRs to contain an LDL-
Petrie, Emma J. +3 more
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Targeting RXFP1 by Ligustilide: A novel therapeutic approach for alcoholic hepatic steatosis
International ImmunopharmacologyLigustilide (Lig) is the main active ingredient of Umbelliferae Angelicae Sinensis Radix (Chinese Angelica) and Chuanxiong Rhizoma (Sichuan lovase rhizome). Lig possesses various pharmacological properties and could treat obesity by regulating energy metabolism.
Hong-Xu, Yang +5 more
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The Discovery of C7-Substituted Norbornyl Bisamides as RXFP1 Small Molecule Agonists
Journal of Medicinal ChemistryHuman relaxin-2 (relaxin, H2-RLX, RLN2), an endogenous hormone associated with mammalian pregnancy, and its cognate receptor relaxin family peptide receptor 1 (RXFP1) have been implicated as important modulators of cardiovascular function and agonism of RXFP1 may potentially be utilized for the treatment of heart failure.
Shun Su +21 more
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Ligand-activated RXFP1 gene therapy ameliorates pressure overload-induced cardiac dysfunction
Molecular Therapy, 2021Constanze Schmidt +2 more
exaly