Expression of Relaxin Family Peptide Receptors 1 and 3 in the Ovarian Follicle of Japanese Quail [PDF]
The Journal of Poultry ScienceIn our previous studies, we demonstrated that the primary source of relaxin 3 (RLN3) in Japanese quail is ovarian granulosa cells. Although several relaxin family peptide (RXFP) receptors have been sequenced, the intricacies of these receptors in avian ...
Khoi X. Hoang +3 more
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Rh-relaxin-2 attenuates oxidative stress and neuronal apoptosis via ERK-nNOS-NO pathway after germinal matrix hemorrhage in rats [PDF]
Fluids and Barriers of the CNSOxidative stress and neuronal apoptosis could be an important factor leading to post-hemorrhagic consequences after germinal matrix hemorrhage (GMH). Previously study have indicated that relaxin 2 receptor activation initiates anti-oxidative stress and ...
Jun Liu +13 more
doaj +2 more sources
Immune cell uptake of glycinated nanoparticles conjugated to anti-fibrotic peptides enables their prolonged activity and oral administration [PDF]
Journal of Biomedical ScienceBackground Fibrosis is a hallmark of various chronic diseases, for which there is no effective cure. Whilst the recombinant form of the human peptide hormone, relaxin (RLX), is being clinically evaluated for its cardioprotective including anti-fibrotic ...
Deidree V. N. Somanader-Livera +9 more
doaj +2 more sources
Re‐PERFUSE: Phase 1b study of AZD3427, a novel relaxin receptor agonist, on renal perfusion in HFrEF patients [PDF]
ESC Heart Failure, Volume 12, Issue 6, Page 4495-4502, December 2025.Abstract Aims Renal impairment frequently coexists with heart failure (HF) and is associated with increased risk of poor clinical outcomes. This highlights the urgent need for therapies targeting both cardiac and renal dysfunction. AZD3427, a long‐acting recombinant fusion protein and relaxin analogue that selectively activates the relaxin family ...
Marcin Ufnal +9 more
wiley +2 more sources
Correction: Sun et al. Engineered Adipose-Derived Stem Cells Overexpressing RXFP1 via CRISPR Activation Ameliorate Erectile Dysfunction in Diabetic Rats. Antioxidants 2023, 12, 171 [PDF]
Antioxidants (Basel)Taotao Sun +6 more
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MicroRNA-144-3p targets relaxin/insulin-like family peptide receptor 1 (RXFP1) expression in lung fibroblasts from patients with idiopathic pulmonary fibrosis [PDF]
Journal of Biological Chemistry, 2019 Justin A Dutta +2 more
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In a Class of their own – RXFP1 and RXFP2 are unique members of the LGR family [PDF]
Frontiers in Endocrinology, 2015 The leucine-rich repeat-containing G protein-coupled receptors (LGRs) family consists of three groups: type A, B and C and all contain a large extracellular domain made up of the structural motif – the leucine rich repeat.
Emma June Petrie +9 more
doaj +4 more sources
Description of a Large Family with Periodic Fever Carrying a Variant in RXFP1 Gene: A Possible Novel Modulator of Inflammation in Autoinflammatory Diseases [PDF]
Int J Mol SciMarianna Buttarelli +5 more
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Whole genome methylation sequencing in blood identifies extensive differential DNA methylation in mild cognitive impairment (MCI) [PDF]
Alzheimer's &Dementia, Volume 20, Issue S2, December 2024.Abstract Background Whole genome methylation sequencing (WGMS) in blood identifies extensive differential DNA methylation between persons who are cognitively unimpaired (CU) and those with late‐onset dementia due to Alzheimer’s disease (AD). Here we investigate differentially methylated positions (DMPs) in persons with mild cognitive impairment (MCI ...
Andy Madrid +8 more
wiley +2 more sources
Ligand-activated RXFP1 gene therapy ameliorates pressure overload-induced cardiac dysfunction [PDF]
Molecular Therapy, 2021 Constanze Schmidt +2 more
exaly +2 more sources