Results 21 to 30 of about 1,276 (166)

Rh-relaxin-2 attenuates degranulation of mast cells by inhibiting NF-κB through PI3K-AKT/TNFAIP3 pathway in an experimental germinal matrix hemorrhage rat model

Journal of Neuroinflammation, 2020
Background Mast cells play an important role in early immune reactions in the brain by degranulation and the consequent inflammatory response. Our aim of the study is to investigate the effects of rh-relaxin-2 on mast cells and the underlying mechanisms ...
Peng Li, Gang Zhao, Fanfan Chen, Yan Ding, Tianyi Wang, Shengpeng Liu, Weitian Lu, Weilin Xu, Jerry Flores, Umut Ocak, Tongyu Zhang, John H. Zhang, Jiping Tang   +12 more
doaj   +1 more source

Synthetic short-chain peptide analogues of H1 relaxin lack affinity for the RXFP1 receptor and relaxin-like bioactivity. Clues to a better understanding of relaxin agonist design

Frontiers in Pharmacology, 2022
The peptide hormone relaxin (RLX), also available as clinical-grade recombinant protein (serelaxin), holds great promise as a cardiovascular and anti-fibrotic agent but is limited by the pharmacokinetic issues common to all peptide drugs.
Annunziata D'Ercole, Annunziata D'Ercole, Silvia Nistri, Lorenzo Pacini, Lorenzo Pacini, Alfonso Carotenuto, Federica Santoro, Anna Maria Papini, Anna Maria Papini, Ross A. D. Bathgate, Daniele Bani, Paolo Rovero, Paolo Rovero   +12 more
doaj   +1 more source

Characterization of Relaxin Receptor (RXFP1) Desensitization and Internalization in Primary Human Decidual Cells and RXFP1-Transfected HEK293 Cells [PDF]

Endocrinology, 2008
We report here the desensitization and internalization of the relaxin receptor (RXFP1) after agonist activation in both primary human decidual cells and HEK293 cells stably transfected with RXFP1. The importance of beta-arrestin 2 in these processes has also been demonstrated.
András, Kern, Gillian D, Bryant-Greenwood   +1 more
openaire   +2 more sources

A novel role for relaxin-2 in the pathogenesis of primary varicosis. [PDF]

PLoS ONE, 2012
BACKGROUND: Varicose veins affect up to 40% of men and up to 51% of women. The pathophysiology of primary varicosis is poorly understood. Theories ranging from incompetence of the venous valves to structural changes in the vein wall have been proposed ...
Julia Adams, Sarah Schott, Arno Bern, Matthias Renz, Kristian Ikenberg, Claus Garbe, Christian Busch   +6 more
doaj   +1 more source

Relaxin-2 improves type I diabetes mellitus-induced erectile dysfunction in rats by protecting cavernous endothelial and smooth muscle function, and inhibiting penile fibrosis and apoptosis. [PDF]

Andrology
Abstract Background Diabetes mellitus‐induced erectile dysfunction (DMED) responds poorly to first‐line treatments, necessitating the development of new therapeutic strategies. Relaxin‐2 (RLX‐2) plays a crucial role in protecting vascular endothelium, vasodilatation, and antifibrosis in various diseases.
Tu B, Liu K, Wen B, Hu P, Sun T, Li B, Sulaiman M, Jiang S, Wang T, Liu J, Luan Y.   +10 more
europepmc   +2 more sources

Synthesis of fluorescent analogues of relaxin family peptides and their preliminary in vitro and in vivo characterization

Frontiers in Chemistry, 2013
Relaxin, a heterodimeric polypeptide hormone, is a key regulator of collagen metabolism and multiple vascular control pathways in humans and rodents.
Linda eChan, Linda eChan, Craig eSmith, Craig eSmith, Berenice eChua, Feng eLin, Ross eBathgate, Ross eBathgate, Ross eBathgate, Frances eSeparovic, Andrew eGundlach, Andrew eGundlach, M. Akhter eHossain, M. Akhter eHossain, M. Akhter eHossain, John eWade, John eWade, John eWade   +17 more
doaj   +1 more source

Activation of Relaxin Family Receptor 1 from different mammalian species by relaxin peptide and small molecule agonist ML290

Frontiers in Endocrinology, 2015
Relaxin peptide (RLN), which signals through the relaxin family peptide 1 (RXFP1) GPCR receptor, has shown therapeutic effects in an acute heart failure clinical trial.
Zaohua eHuang, Courtney eMyhr, Ross A.D. Bathgate, Brian eHo, Amaya eBueno, Xin eHu, Jingbo eXiao, Noel eSouthall, Elena eBarnaeva, Irina U Agoulnik, Juan eMarugan, Marc eFerrer, Alexander I Agoulnik   +12 more
doaj   +1 more source

Expression and Characterization of Relaxin Family Peptide Receptor 1 Variants

Frontiers in Pharmacology, 2022
G-protein coupled receptors (GPCR) transduce extracellular stimuli into the cell interior and are thus centrally involved in almost all physiological-neuronal processes.
David Speck, Gunnar Kleinau, Mark Meininghaus, Antje Erbe, Antje Erbe, Alexandra Einfeldt, Alexandra Einfeldt, Michal Szczepek, Patrick Scheerer, Patrick Scheerer, Vera Pütter, Vera Pütter   +11 more
doaj   +1 more source

Human relaxins (RLNH1, RLNH2), their receptor (RXFP1) and fetoplacental growth [PDF]

Reproduction, 2017
Abstract Relaxin, a systemic and placental hormone, has potential roles in fetoplacental growth. Human placenta expresses two RLN genes, RLNH1 and RLNH2. Maternal obesity is common and is associated with abnormal fetal growth. Our aims were to relate systemic and cord blood RLNH2, placental RLNs and their receptor (RXFP1) with ...
Kelly, Yamasato, Pai-Jong Stacy, Tsai, James, Davis, Sandra Y, Yamamoto, Gillian D, Bryant-Greenwood   +4 more
openaire   +2 more sources

Anti-apoptotic and Matrix Remodeling Actions of a Small Molecule Agonist of the Human Relaxin Receptor, ML290 in Mice With Unilateral Ureteral Obstruction

Frontiers in Physiology, 2021
Diseases, such as diabetes and hypertension, often lead to chronic kidney failure. The peptide hormone relaxin has been shown to have therapeutic effects in various organs.
Hooi Hooi Ng, Mariluz Soula, Bryan Rivas, Kenneth J. Wilson, Juan J. Marugan, Alexander I. Agoulnik   +5 more
doaj   +1 more source