Tensile strain increases expression of CCN2 and COL2A1 by activating TGF-beta-Smad2/3 pathway in chondrocytic cells [PDF]
Physiologic mechanical stress stimulates expression of chondrogenic genes, such as multifunctional growth factor CYR61/CTGF/NOV (CCN) 2 and alpha 1(II) collagen (COL2A1), and maintains cartilage home-ostasis.
Fujii, Masataka +6 more
core +1 more source
Automatic localization of closely spaced cochlear implant electrode arrays in clinical CTs
PURPOSE Cochlear implants (CIs) are neural prosthetic devices that provide a sense of sound to people who experience profound hearing loss. Recent research has indicated that there is a significant correlation between hearing outcomes and the ...
Yiyuan Zhao +3 more
semanticscholar +1 more source
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He +8 more
wiley +1 more source
Why do we know so little about return to work after carpal tunnel release?
Carpal tunnel syndrome (CTS) is a common nerve entrapment with a prevalence ranging between 2.7–4.9%, depending on the definition, in a representative adult population (1).
Eira Viikari-Juntura
doaj +1 more source
Electronic structure and transport properties of Cu-deficient kuramite Cu3-xSnS4
Electrical and thermal transport properties of Cu-deficient kuramite Cu3-xSnS4 (CTS) was examined as a possible earth-abundant thermoelectric material. Crystallographic structure of CTS was characterized by partial disorder between Cu and Sn. In contrast
Goto, Yosuke +3 more
core +1 more source
Functional Measures Developed for Clinical Populations Identified Impairment Among Active Workers with Upper Extremity Disorders [PDF]
PURPOSE: Few studies have explored measures of function across a range of health outcomes in a general working population. Using four upper extremity (UE) case definitions from the scientific literature, we described the performance of functional ...
Buckner-Petty, Skye +6 more
core +2 more sources
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Synthesis of silver nanoparticles in chitosan, gelatin and chitosan/gelatin bionanocomposites by a chemical reducing agent and their characterization [PDF]
In this research, silver nanoparticles (AgNPs) were synthesized in chitosan (Cts), Cts/gelatin and gelatin suspensions using a chemical reducing agent.
Ahmad @ Ayob, Mansor +4 more
core +2 more sources
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck +12 more
wiley +1 more source
Socioscientific conflictive in science education: propositions to biolow and human dignity
The scientific enterprise has not impartial, objective, free from controversies and/or contradictory elements. Rather, it is permeated by values and interests.
Nívia Magalhães da Silva Freitas +3 more
doaj +1 more source

