Results 51 to 60 of about 73,785 (268)

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Risk factors of hospitalization for carpal tunnel syndrome among the general working population

Scandinavian Journal of Work, Environment & Health, 2020
OBJECTIVES: Carpal tunnel syndrome (CTS) causes a considerable amount of sick leave and healthcare costs. The etiology of CTS is multifactorial, involving both personal and occupational risk factors.
Sina Hulkkonen, Rahman Shiri, Juha Auvinen, Jouko Miettunen, Jaro Karppinen, Jorma Ryhänen   +5 more
doaj   +1 more source

The bilaterality of idiopathic carpal tunnel syndrome among manual workers

International Journal of Occupational Medicine and Environmental Health, 2020
Objectives To evaluate: a) the prevalence of bilateral idiopathic carpal tunnel syndrome (CTS) in manual workers; b) a correlation between the duration of unilateral and bilateral CTS symptoms; c) a correlation between the onset of CTS symptoms in the ...
Magdalena Lewańska
doaj   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

The prevalence and incidence of carpal tunnel syndrome in US working populations

Scandinavian Journal of Work, Environment & Health, 2014
In the September issue of the Scandinavian Journal of Work, Environment and Health, Dale et al (1) estimated the prevalence and incidence of carpal tunnel syndrome (CTS) by pooling the raw individual-level data of six diverse prospective studies in US ...
Rahman Shiri
doaj   +1 more source

Socioscientific conflictive in science education: propositions to biolow and human dignity

Revista Brasileira de Ensino de Ciência e Tecnologia, 2019
The scientific enterprise has not impartial, objective, free from controversies and/or contradictory elements. Rather, it is permeated by values and interests.
Nívia Magalhães da Silva Freitas, João Guilherme Ribeiro, Eduardo Paiva de Pontes Vieira, Nadia Magalhães da Silva Freitas   +3 more
doaj   +1 more source

O tratamento de água como tema potencial no ensino de Química e sua contribuição no processo de formação cidadã na educação básica

Revista de Ensino de Ciências e Matemática, 2020
A proposta Ciência, Tecnologia e sociedade (CTS) busca orientar a inserção de temas sociais no currículo escolar. O presente trabalho apresenta o uso da proposta CTS, como objetivo, na investigação do tema “Qualidade da água” na busca por: reflexão ...
Willian Ayala Correa, Hebert Lee Barbosa Veríssimo de Barros, Ademir Souza Pereira   +2 more
doaj   +1 more source

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source