Results 81 to 90 of about 424,490 (383)

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Analisis Kekuatan Mekanik pada Struktur Cooling Tank Section Untai FASSIP-03 NT Berbasis Simulasi Software

Semesta Teknika, 2022
Untai Fasilitas Simulasi Sistem Pasif-03 Nanobubble Transparent (FASSIP-03 NT) mulai didesain pada tahun 2021. Komponen pada untai FASSIP-03 NT terdiri dari Heating Tank Section (HTS) dan Cooling Tank Section (CTS) yang dilengkapi dengan Helical Heat ...
Dedy Haryanto, Giarno Giarno, Adhika Enggar Pamungkas, Ainur Rosidi, Gregorius Bambang Heru Kusnugroho, Mulya Juarsa   +5 more
doaj   +1 more source

Observer variability for Lung-RADS categorisation of lung cancer screening CTs: impact on patient management

European Radiology, 2018
ObjectivesLung-RADS represents a categorical system published by the American College of Radiology to standardise management in lung cancer screening. The purpose of the study was to quantify how well readers agree in assigning Lung-RADS categories to ...
S. V. van Riel, C. Jacobs, E. Scholten, R. Wittenberg, M. M. Winkler Wille, B. de Hoop, Ralf Sprengers, O. Mets, B. Geurts, M. Prokop, C. Schaefer-Prokop, B. van Ginneken   +11 more
semanticscholar   +1 more source

Feasibility of a ctDNA multigenic panel for non‐small‐cell lung cancer early detection and disease surveillance

Molecular Oncology, EarlyView.
Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande, Marcela de Oliveira Silva, Mariana Bisarro dos Reis, Rodrigo de Oliveira Cavagna, Luciane Sussuchi, Icaro Alves Pinto, Natalia Zampieri Pontes, Rodrigo Sampaio Chiarantano, Flavio Augusto Ferreira da Silva, Pedro de Marchi, Letícia Ferro Leal, Rui M. Reis   +11 more
wiley   +1 more source

(Core Trust) Seal your repository!

Mitteilungen der Vereinigung Österreichischer Bibliothekarinnen und Bibliothekare, 2020
Eine Arbeitsgruppe, die im Rahmen des Netzwerks für RepositorienmanagerInnen (RepManNet) entstanden ist, hat sich mit gängigen Zertifizierungen für Repositorien beschäftigt. Weiters wurden aktuelle Vorgaben der Forschungsförderer FWF und EU herangezogen.
Doris Ernst, Gertraud Novotny, Eva Maria Schönher   +2 more
doaj   +1 more source

Tailored gamification and serious game framework based on fuzzy logic for saving energy in connected thermostats [PDF]

, 2020
Connected thermostats (CTs) often save less energy than predicted because consumers may not know how to use them and may not be engaged in saving energy.
Mata, O, Meier, A, Molina, A, Méndez, JI, Peffer, T, Ponce, P   +5 more
core  

Plasma extrachromosomal circular DNA as a biomarker in EGFR‐targeted therapy of non‐small cell lung cancer

Molecular Oncology, EarlyView.
Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard, Sarmad Mehmood, Eva Boysen Fynboe Ebert, Peter Meldgaard, Anindya Dutta, Boe S. Sorensen   +5 more
wiley   +1 more source

Using job-title-based physical exposures from O*NET in an epidemiological study of carpal tunnel syndrome [PDF]

, 2014
OBJECTIVE: We studied associations between job title based measures of force and repetition and incident carpal tunnel syndrome (CTS). BACKGROUND: Job exposure matrices (JEMs) are not commonly used in studies of work-related upper extremity disorders ...
Dale, Ann Marie, Evanoff, Bradley A, Franzblau, Alfred, Zeringue, Angelique   +3 more
core   +1 more source

Development of a strategy for calibrating the novel SiPM camera of the SST-1M telescope proposed for the Cherenkov Telescope Array [PDF]

, 2017
CTA will comprise a sub-array of up to 70 small size telescopes (SSTs) at the southern array. The SST-1M project, a 4 m-diameter Davies Cotton telescope with 9 degrees FoV and a 1296 pixels SiPM camera, is designed to meet the requirements of the next ...
Alispach, C., Borkowski, J., Bulik, T., Cadoux, F., Coco, V., CTA SST-1M Collaboration, della Volpe, D., Ekoume, T. R. S. Njoh, Favre, Y., Grudzińska, M., Heller, M., Jamrozy, M., Kasperek, J., Lyard, E., Mach, E., Mandat, D., Michałowski, J., Moderski, R., Montaruli, T., Nagai, A., Neronov, A., Niemiec, J., Ostrowski, M., Paśko, P., Pech, M., Pujadas, I. Troyano, Rafalski, J., Rajda, P., Samarai, I. Al, Schovanek, P., Seweryn, K., Skowron, K., Sliusar, V., Stawarz, Ł., Stodulska, M., Stodulski, M., Travnicek, P., Walter, R., Zagdański, A., Ziȩtara, K.   +39 more
core   +2 more sources

Screening for lung cancer: A systematic review of overdiagnosis and its implications

Molecular Oncology, EarlyView.
Low‐dose computed tomography (CT) screening for lung cancer may increase overdiagnosis compared to no screening, though the risk is likely low versus chest X‐ray. Our review of 8 trials (84 660 participants) shows added costs. Further research with strict adherence to modern nodule management strategies may help determine the extent to which ...
Fiorella Karina Fernández‐Sáenz, Laura de la Torre‐Perez, David R Baldwin, Carlijn van der Aalst, Mangesh Thorat, David Ritchie, Andre L Carvalho, Carolina Espina, Ivan Solà, Carlos Canelo‐Aybar, Moira Magdalena Pissinis, Pablo Alonso‐Coello, Ana Carolina Pereira Nunes Pinto   +12 more
wiley   +1 more source