Results 31 to 40 of about 19,353 (259)

Potential Activity of Non-Platinum Metal-Based Organic Complexes Against Different Cancer Cell Types

Pharmaceuticals
The disadvantages of Cisplatin in anticancer treatment are connected to its poor selectivity, resistance developed of cancers to the drug, and its toxicity against normal organs. An important strategy in anticancer treatment is the synthesis and clinical
Dobrina Tsvetkova, Stefka Ivanova, Danka Obreshkova   +2 more
doaj   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Square planar Au(III), Pt(II) and Cu(II) complexes with quinoline-substituted 2,2′:6′,2″-terpyridine ligands: From in vitro to in vivo biological properties

European Journal of Medicinal Chemistry, 2021
Cancer is the second leading cause of death worldwide. Cisplatin has challenged cancer treatment; however, resistance and side effects hamper its use. New agents displaying improved activity and more reduced side effects relative to cisplatin are needed.
Katarzyna Choroba, Barbara Machura, Agata Szlapa-Kula, Jan G. Malecki, Luis Raposo, Catarina Roma-Rodrigues, Sandra Cordeiro, Pedro V. Baptista, Alexandra R. Fernandes   +8 more
openaire   +5 more sources

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Complexing Behaviour of 5-Amino-1,3,4-Thiazole-2-thiol. II. Complexes of Ni(II), Rh(I), Pd(II), Pt(II), Au(III) and Cu(II) [PDF]

Bulletin of the Chemical Society of Japan, 1975
Abstract Complexes of Ni(II), Rh(I) Pd(II), Pt(II), Au(III) and Cu(II) with 5-Amino-1,3,4-thiadiazole-2-thiol have been prepared. Probable structures have been proposed for the complexes on the basis of visible and infrared spectral and magnetic susceptibility data and results of chemical analysis.
M R Gajendragad, U Agarwala
openaire   +1 more source

Evolution‐guided yeast complementation reveals functional differences in human PSPH variants

FEBS Open Bio, EarlyView.
Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez, Diana Ascencio, Miguel Vallebueno‐Estrada, Eduardo González‐Orozco, Christian Eduardo Martínez‐Guerrero, Rafael Montiel, Alexander DeLuna   +6 more
wiley   +1 more source

Fluid Origin and Evolution of the Roc Blanc Silver Deposit (Jebilet Massif, Variscan Belt, Morocco): Constraints from Geology and Fluid Inclusions

Geofluids, 2022
The Roc Blanc Pb-Zn-Ag-Au vein deposit is located in the NW of Marrakech, in the Central Jebilet massif. It is spatially related to Bramram-Tabouchennt-Bamega (BTB) granodioritic pluton (ca. 330 Ma) metamorphism aureole.
Amal El Arbaoui, Ismaïla N’Diaye, Zaineb Hajjar, Amina Wafik, Abdelhak Boutaleb, Said Ilmen, Abderrahim Essaifi, Mohammed Bouabdellah   +7 more
doaj   +1 more source

Whole Genome Sequence Analysis of Cupriavidus necator C39, a Multiple Heavy Metal(loid) and Antibiotic Resistant Bacterium Isolated from a Gold/Copper Mine

Microorganisms, 2023
Here a multiple heavy metal and antibiotic resistant bacterium Cupriavidus necator C39 (C. necator C39) was isolated from a Gold-Copper mine in Zijin, Fujian, China. C. necator C39 was able to tolerate intermediate concentrations of heavy metal(loid)s in
Zhenchen Xie, Dan Wang, Ibtissem Ben Fekih, Yanshuang Yu, Yuanping Li, Hend Alwathnani, Martin Herzberg, Christopher Rensing   +7 more
doaj   +1 more source

Structural studies and functional engineering of NanX: an anhydro‐sialic acid transporter from Escherichia coli

FEBS Open Bio, EarlyView.
Biophysical characterisation shows that NanX, a membrane transport protein from the major facilitator superfamily (MFS), forms both monomers and dimers after purification. AlphaFold modelling and substrate docking provide information on residues likely involved in substrate recognition for NanX and another MFS member, NanT.
Michael C. Newton‐Vesty, Kelsi R. Hall, Zachary D. Tillett, Liam S. Turk, James S. Davies, Michael J. Currie, Hamish G. Brown, Sepideh Valimehr, Peter D. Mace, Andrew E. Whitten, Santosh Panjikar, Eric Hanssen, Rachel A. North, Renwick C.J. Dobson   +13 more
wiley   +1 more source

In silico and in vitro exploration of a tyrosinase for biocatalytic production of catechols

FEBS Open Bio, EarlyView.
Tyrosinase from Ralstonia pseudosolanacearum is a promising biocatalyst for producing valuable catechols from monophenol substrates. This tyrosinase is uniquely suited to this due to its high monophenolase : diphenolase ratio. We combined in silico docking and in vivo kinetic characterisation of this tyrosinase with 11 industrially relevant monophenols,
James Britton, Fang Zhao, Reeta Davis, Meg Walsh, Kevin E O'Connor, David O'Connell, Tanja Narancic   +6 more
wiley   +1 more source