Results 91 to 100 of about 15,560 (192)

Molecular Simulations of Polymer‐based Drug Nanocarriers: From Physical and Structural Properties to Controlled Release

Advanced Healthcare Materials, Volume 15, Issue 4, 26 January 2026.
Polymer‐based drug delivery systems can effectively overcome the limitations of free drugs in terms of solubility, stability, and plasma half‐life, yet their development has traditionally relied on time‐consuming trial‐and‐error approaches. This review highlights recent advances in applying molecular simulation to the design of polymer‐based drug ...
Ping Gao, Xin Jiang, Jinyu Li, Julien Nicolas, Tâp Ha‐Duong   +4 more
wiley   +1 more source

Exploring Nanotechnologies for the Effective Therapy of Malaria using Plant-Based Medicines [PDF]

, 2016
Malaria is a potentially lethal disease caused by species of the plasmodium parasite. Despite the advances in the interventions for its control and approaches to manage fatality, morbidity and mortality rates associated with malaria are still high.
Oga, Enoche Florence, Singh, Kamalinder
core   +1 more source

Cucurbitacin E-induced disruption of the actin and vimentin cytoskeleton in prostate carcinoma cells

Biochemical Pharmacology, 1996
Cucurbitacin E has been identified by an empiric screening strategy as a sterol with potent growth inhibitory activity in vitro directed against prostate carcinoma explants (IC50 of 7-50 nM in 2- to 6-day exposures). The mechanism of cucurbitacin cytoxicity has not been elucidated previously. In the present study, we observed that cucurbitacin E caused
K L, Duncan, M D, Duncan, M C, Alley, E A, Sausville   +3 more
openaire   +2 more sources

Cytotoxic Effects of Cucurbitacin I and on Breast Cancer Cells

Natural Product Communications, 2018
The objective of this study was to investigate the inhibitory effect of cucurbitacin I (CuI) and Ecballium elaterium L. (fruit juice and chloroform extract) on breast cancer cells (MCF-7 and MDA-MB-231). The CuI content of E.
Kadir Yıilmaz, Fuat Karakuş, Ergül Eyol, Emir Tosun, İsmet Yıilmaz, Songül Ünüvar   +5 more
doaj   +1 more source

Effective Medicinal Plant in Cancer Treatment, Part 2. [PDF]

, 2017
Cancer is the second cause of death after cardiovascular diseases. With due attention to rapid progress in the phytochemical study of plants, they are becoming popular because of their anticancer effects.
Asadi-Samani, Majid., Behzadifar, Masoud., Kooti, Wesam., Nouri, Bijan., Sadeghi, Fatemeh., Servatyari, Karo., Zare Marzouni, Hadi.   +6 more
core  

Stabilization of cucurbitacin E-glycoside, a feeding stimulant for diabroticite beetles, extracted from bitter Hawkesbury watermelon

Journal of Insect Science, 2002
Cucurbitacins are feeding stimulants for diabroticite beetles, including corn rootworms and cucumber beetles, which can be added to a bait containing an insecticide thereby reducing the levels of other insecticide treatments needed to control these pests.
Phyllis A.W. Martin, Michael Blackburnsmall, Robert F.W. Schroder, Koharto Matsuo, Betty W. Li   +4 more
doaj  

Amphiphilic block copolymers from a renewable Ɛ-decalactone monomer: prediction and characterization of micellar core effects on drug encapsulation and release [PDF]

, 2016
Here we describe a methoxy poly(ethyleneglycol)-b-poly(ε-decalactone) (mPEG-b-PεDL) copolymer and investigate the potential of the copolymer as a vehicle for solubilisation and sustained release of indomethacin (IND). The indomethacin loading and release
Aliabadi, Allen, Bansal, Cabral, Cajot, Chan, Chen, Chuma, Danquah, Dwan'Isa, Endrizzi, Forrest, Gadelle, Glavas, Gou, Hillmyer, Huynh, Jones, Kataoka, Kim, Lai, Lavasanifar, Lavasanifar, Letchford, Lin, Liu, Liu, Lu, Lu, Mahmud, Miller, Nagarajan, Nishiyama, Olsen, Patel, Patel, Patel, Pratt, Randolph, Romero-Guido, Rupp, Scarano, Schneiderman, Schneiderman, Schroder, Simon, Thakral, Thambi, VanKrevelen, Winkler, Woodruff, Yan, Yang, Yokoyama, Yoon, Yuan, Zhang, Zhang, Zou   +58 more
core   +1 more source

Diabrotica virgifera virgifera LeConte in confrontation mood : simultaneous geographical and host spectrum expansion in southeastern Slovenia [PDF]

, 2008
Diabrotica virgifera virgifera LeConte, in its original North American habitat also known as western corn rootworm beetle, actively continues its expansion to new territories and uses Homo sapiens as its prime vector.
Dinnesen, Sven, Hummel, Hans E., Modic, Spela, Nedelev, Tenio, Ulrichs, Christian, Urek, Gregor   +5 more
core  

Growth inhibitory effect of Cucurbitacin E on breast cancer cells.

International journal of clinical and experimental pathology, 2014
Due its inhibitory effects on chemical carcinogenesis and inflammation, Cucurbitacins have been proposed as an effective agent for the prevention or treatment of human cancers. In this study, we aimed to explore the effect of Cucurbitacin E (CuE) on human breast cancer cells.The inhibitory effect of CuE on proliferation of Bcap37 and MDA-MB-231 cells ...
Tian, Lan, Linling, Wang, Qian, Xu, Weiguo, Liu, Hongchuan, Jin, Weimin, Mao, Xian, Wang, Xiaojia, Wang   +7 more
openaire   +1 more source

Citrullus mucosospermus Extract Exerts Protective Effects against Methionine- and Choline-Deficient Diet-Induced Nonalcoholic Steatohepatitis in Mice

Foods
In recent years, there has been increasing interest in exploring the potential therapeutic advantages of Citrullus mucosospermus extracts (CME) for nonalcoholic steatohepatitis (NASH). In this study, we investigated the therapeutic effects of CME on NASH
Sun Young Park, Ji Eun Kim, He Mi Kang, Ki Ho Park, Byoung Il Je, Ki Won Lee, Dae Youn Hwang, Young Whan Choi   +7 more
doaj   +1 more source