Pharmacokinetics and Biological Activity of Cucurbitacins
Pharmaceuticals, 2022 Cucurbitacins are a class of secondary metabolites initially isolated from the Cucurbitaceae family. They are important for their analgesic, anti-inflammatory, antimicrobial, antiviral, and anticancer biological actions.
Edelmiro Santiago-Osorio +2 more
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Recent Advances in the Application of Cucurbitacins as Anticancer Agents [PDF]
Metabolites, 2023 Cucurbitacins are tetracyclic triterpenoid secondary metabolites, widely distributed in the Cucurbitaceae family. These bitter-tasting compounds act primarily as defense mechanisms against external injuries, and thus against herbivores, and furthermore ...
Bartłomiej Zieniuk +1 more
doaj +2 more sources
Cucurbitacins B, E and I Concentrations and Relationship with Drought Tolerance in Bottle Gourd [Lagenaria siceraria (Molina) Standl.] [PDF]
Plants, 2023 Bottle gourd [Lagenaria siceraria (Molina) Standl.]) is a relatively drought-tolerant cucurbit due to the high composition of unique biochemical compositions, including cucurbitacin.
Phumzile Mkhize +2 more
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Mass Spectrometric Analysis of Cucurbitacins and Dihydrocucurbitacins from the Tuber of Citrullus naudinianus [PDF]
Biomolecules, 2023 The vast pool of structurally and functionally distinct secondary metabolites (i.e., natural products (NPs)) is constantly being expanded, a process also driven by the rapid progress in the development of analytical techniques. Such NPs often show potent
Moritz Benka +12 more
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Hydroalcoholic Extracts of Cucumis prophetarum L. Affect the Insulin Signaling Pathway in an In Vitro Model of Insulin-Resistant L6 Myotubes [PDF]
MoleculesType 2 diabetes mellitus (T2DM) can be traditionally treated by edible and medicinal species rich in flavonoids and triterpenoids known for their metabolic benefits. Cucumis prophetarum L.
Zewdie Mekonnen +14 more
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Pharmacokinetic Profile of Extracts from the Chayote (Sechium edule) H387 07 Hybrid and Phytochemical Characterization of Its Segregant H387 M16 for Potential Therapeutic Applications [PDF]
MoleculesThe hybrid Sechium edule H387 07, commonly known as chayote, has shown potential as an antiproliferative, cytotoxic, and pro-apoptotic agent in the murine leukemia cell lines P388 (macrophagic) and J774 (monocytic) and in the myelomonocytic leukemia cell
Eugenia Elisa Delgado-Tiburcio +6 more
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Cucurbitacins as potential anticancer agents: new insights on molecular mechanisms [PDF]
Journal of Translational Medicine, 2022 Since ancient times, plants have been an extensive reservoir of bioactive compounds with therapeutic interest for new drug development and clinical application.
Carla Varela +6 more
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Cucurbitacins: A Focus on Cucurbitacin E As A Natural Product and Their Biological Activities [PDF]
Pharmaceutical Sciences, 2021 For the last years, different types of cucurbitacins have been extracted from various species of Cucurbitaceae family. For this review, all related papers were accumulated by searching electronic databases in the English language, including PubMed ...
Moazzameh Ramezani +3 more
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Cucurbitacins from the Leaves of Citrullus colocynthis (L.) Schrad
Molecules, 2015 Two new tetracyclic cucurbitane-type triterpene glycosides were isolated from an ethyl acetate extract of Citrullus colocynthis leaves together with four known cucurbitacins.
Rachid CHAWECH +2 more
exaly +3 more sources
Integrated metabolomic and transcriptomic analyses elucidates the molecular mechanisms underlying cucurbitacin accumulation and bitterness development in Luffa fruits [PDF]
BMC Plant BiologyThe fruits of Luffa in the Cucurbitaceae family are characterized by a bitter taste, which is mainly attributed to cucurbitacin. However, the types of cucurbitacins related to bitterness and the molecular mechanism of cucurbitacin accumulation during ...
Dening Zhu +4 more
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