Squirting Cucumber, Ecballium elaterium (L.) A. Ritch: An Update of Its Chemical and Pharmacological Profile [PDF]
MoleculesEcballium elaterium, also known as squirting cucumber, is a plant which is widespread in temperate regions of Europe, Africa and Asia. The plant is considered to be one of the oldest used drugs. In the last decades, E.
Attilio Anzano +3 more
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Bioassay-guided isolation of leishmanicidal cucurbitacins from Momordica charantia [PDF]
Frontiers in PharmacologyIntroductionLeishmaniasis, a neglected tropical parasitic disease, is regarded as a major public health problem worldwide. The first-line drugs for leishmaniasis suffer from limitations related to toxicity and the development of resistance in certain ...
Maria Carolina Silva Marques +4 more
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Cucurbitacin IIa Alleviates Colitis via Promoting the Release of Host-Derived Extracellular Vesicles Encapsulating microRNA-30b-5p [PDF]
Journal of Inflammation ResearchYinyin Zhao,1 Binyuan Jiang,2 Shengnan Zuo3 1Ningbo Institute of Innovation for Combined Medicine and Engineering (NIIME), The Affiliated LiHuiLi Hospital of Ningbo University, Ningbo, People’s Republic of China; 2Medical Research Center of the ...
Zhao Y, Jiang B, Zuo S
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Total cucurbitacins from Herpetospermum pedunculosum pericarp do better than Hu-lu-su-pian (HLSP) in its safety and hepatoprotective efficacy [PDF]
Frontiers in PharmacologyThe pericarp of Herpetospermum pedunculosum (HPP) has traditionally been used for treating jaundice and hepatitis. However, the specific hepatoprotective components and their safety/efficacy profiles remain unclear.
Wen-Ya Liu +7 more
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Phytochemical Composition, Health Benefits, Functional Properties, and Food Applications of Pumpkin Seeds. [PDF]
Food Sci NutrPumpkin seeds (Cucurbita spp.) are rich in bioactive compounds including proteins, unsaturated fatty acids, dietary fiber, vitamins (E and B‐complex), minerals (zinc, magnesium, iron), and phytochemicals such as phenolics, flavonoids, and phytosterols.
Kassa MG, Teferi DA.
europepmc +2 more sources
Cucurbitacins as Potent Chemo-Preventive Agents: Mechanistic Insight and Recent Trends
Biomolecules, 2022 Cucurbitacins constitute a group of cucumber-derived dietary lipids, highly oxidized tetracyclic triterpenoids, with potential medical uses. These compounds are known to interact with a variety of recognized cellular targets to impede the growth of ...
Hardeep Singh Tuli +12 more
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First Report on the Occurrence of Cucurbitacins in an Italian Melon Landrace (Cucumis melo L.)
Horticulturae, 2023 Scopatizzo, belonging to the Cucumis melo L., is a local variety of Apulia (Southern Italy), which is consumed as unripe melon as an alternative of cucumber due to its better-quality profile and for the absence of cucurbitacins.
Onofrio Davide Palmitessa +8 more
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The cucurbitacins D, E, and I from Ecballium elaterium (L.) upregulate the LC3 gene and induce cell-cycle arrest in human gastric cancer cell line AGS [PDF]
Iranian Journal of Basic Medical Sciences, 2018 Objective(s): Cucurbitacins exhibit a range of anti-cancer functions. We investigated the effects of cucurbitacins D, E, and I purified from Ecballium elaterium (L.) A.
Naser Jafargholizadeh +2 more
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The effect of squash domestication on a belowground tritrophic interaction
Plant-Environment Interactions, 2022 The domestication of plants has commonly resulted in the loss of plant defense metabolites, with important consequences for the plants' interactions with herbivores and their natural enemies.
Charlyne Jaccard +6 more
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Anti-Cancer Effect of Sesquiterpene and Triterpenoids from Agarwood of Aquilaria sinensis
Molecules, 2022 Two new guaiane sesquiterpenes, aquisinenoids A and B (1 and 2), two new eudesmane-type sesquiterpenoids, aquisinenoids C and D (3 and 4), one new cucurbitacin, aquisinenoid E (5), and five known cucurbitacins (6–10) were isolated from agarwood of ...
Lili Chen +4 more
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