Results 71 to 80 of about 4,038,445 (259)

Changes in dorsomedial striatum activity during expression of goal-directed vs. habit-like cue-induced cocaine seeking

Addiction Neuroscience
A preclinical model of cue exposure therapy, cue extinction, reduces cue-induced cocaine seeking that is goal-directed but not habit-like. Goal-directed and habitual behaviors differentially rely on the dorsomedial striatum (DMS) and dorsolateral ...
Brooke N. Bender, Sierra J. Stringfield, Mary M. Torregrossa   +2 more
doaj   +1 more source

A Preliminary Examination of Nicotine-Free Electronic Cigarette Use During Cessation From Combustible Cigarettes

Frontiers in Psychiatry, 2019
Despite the availability of smoking cessation strategies, smoking cue-induced craving remains a relatively untreated relapse risk factor. Utilizing nicotine-free electronic cigarettes (e-cigarettes) to extinguish the motivational influence of smoking ...
Alyssa L. Peechatka, Alyssa L. Peechatka, Elena K. Molokotos, Elena K. Molokotos, Maya Zegel, Scott E. Lukas, Scott E. Lukas, Amy C. Janes, Amy C. Janes   +8 more
doaj   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Reminder cues modulate the renewal effect in human predictive learning

Frontiers in Psychology, 2016
Associative learning refers to our ability to learn about regularities in our environment. When a stimulus is repeatedly followed by a specific outcome, we learn to expect the outcome in the presence of the stimulus.
Javier Bustamante, Metin Uengoer, Harald Lachnit   +2 more
doaj   +1 more source

Virtual Reality Technology Use in Cigarette Craving and Smoking Interventions (I “Virtually” Quit): Systematic Review

Journal of Medical Internet Research, 2021
BackgroundOver the last 2 decades, virtual reality technologies (VRTs) have been proposed as a way to enhance and improve smoking cessation therapy.
Merel Keijsers, Maria Cecilia Vega-Corredor, Melanie Tomintz, Simon Hoermann   +3 more
doaj   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

¿Qué aportan las técnicas de exposición a la efectividad de la terapia cognitivo-conductual con parches de nicotina para dejar de fumar?

Psicooncologia, 2006
Objective: To examine whether cue-exposure therapy increases the effectiveness of a multicomponent smoking cessation program that combines cognitive-behavioral techniques with nicotine patches.
María Paz García Vera, Jesús Sanz
doaj  

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

Molecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

Towards virtual reality exposure therapy for cocaine use disorder: A feasibility study of inducing cocaine craving through virtual reality

Addictive Behaviors Reports
Background: Craving is a core symptom of cocaine use disorders (CUD). Inducing craving in exposure to substance cues is of relevant interest for numerous clinical applications.
Thomas Lehoux, Christelle Nithart Porche, Antonio Capobianco, Miguel Gervilla, Flavien Lecuyer, Julien Anthouard, Luisa Weiner   +6 more
doaj   +1 more source