Results 111 to 120 of about 13,278 (264)

Translating Virtual Reality Cue Exposure Therapy for Binge Eating into a Real-World Setting: An Uncontrolled Pilot Study. [PDF]

J Clin Med, 2021
Nameth K, Brown T, Bullock K, Adler S, Riva G, Safer D, Runfola C.   +6 more
europepmc   +1 more source

Flash Assembloids: A Rapid Biofabrication of a Platform for Modeling Early Glioblastoma Invasion at the Glioblastoma–Brain Organoid Interfaces

Advanced Healthcare Materials, EarlyView.
This study presents a bioengineered assembloid (ASM) system combining glioblastoma (GBM) cells in oxidized alginate (OA) microgels with dorsal organoids (DOs). This model simulates brain tumor‐host interactions, revealing enhanced GBM invasion, altered gene expression, and aggressive infiltration patterns, demonstrating ASM as a valuable platform for ...
Chao Liang, Henry Robert Howard, Shihui Chen, Won‐Young Choi, Summer Cao, Arthur Chien, Kevin Zou, Michael Kassiou, Fabien Delerue, Ho Sang Jung, Yeonju Park, Young Mee Jung, Yong‐Dae Kwon, Karrie M. Kiang, Gilberto Ka‐Kit Leung, Ryohichi Sugimura, Ann‐Na Cho, Sang Jin Lee   +17 more
wiley   +1 more source

Lasting reduction of nicotine‐seeking behavior by chronic N‐acetylcysteine during experimental cue‐exposure therapy [PDF]

, 2019
Nicotine‐associated cues can trigger reinstatement in humans as well as in animal models of drug addiction. To date, no behavioral intervention or pharmacological treatment has been effective in preventing relapse in the long term.
Giuseppe Giannotti, Luigi Cervo, Caffino, Lucia, Fumagalli, Fabio, Cervo, Luigi, Di Clemente, Angelo, Marzo, Claudio Marcello, Angelo Di Clemente, Lucia Caffino, Fabio Fumagalli, Claudio Marcello Marzo, Federico Moro, Giannotti, Giuseppe, Moro, Federico   +13 more
core   +1 more source

Development of a Synthetic Hydrogel to Foster Microvascularization of an Endometriosis Microphysiological System

Advanced Healthcare Materials, EarlyView.
ABSTRACT The ascent of novel alternative methods in drug development spotlights the dual needs for improved biological fidelity to in vivo, along with reproducibility, especially in regulatory applications. The need for pre‐clinical models of patient‐derived endometriosis lesions motivates the development of a vascularizable, completely synthetic ...
Lauren Pruett, Laura Bahlmann, Ryan Ogi, Angela Jiao, Priyatanu Roy, Matthew Johnson, David Trumper, Linda Griffith   +7 more
wiley   +1 more source

Multidimensional Cellular Micro‐Compartments to Model Invasive Lobular Carcinoma Dormancy

Advanced Healthcare Materials, EarlyView.
Invasive lobular carcinoma (ILC) is an understudied subtype of breast cancer that is susceptible to late recurrences. In this study, micro‐compartmentalization techniques spanning multiple dimensions, including 2D, pseudo‐3D, and 3D, are integrated to uncover the mechanisms underlying ILC dormancy, revealing the central role of p27Kip1.
Xilal Y. Rima, Sarmila Majumder, Divya S. Patel, Chunyu Hu, Hong Li, Xin Huang, Kim Truc Nguyen, Jacob Doon‐Ralls, Chiranth K. Nagaraj, Mangesh D. Hade, Setty M. Magaña, Eswar Shankar, Xiaoli Zhang, Daniel G. Stover, Bhuvaneswari Ramaswamy, Eduardo Reátegui   +15 more
wiley   +1 more source

Distinct neural responses of ventromedial prefrontal cortex-projecting nucleus reuniens neurons during aversive memory extinction

Molecular Brain
Animals adaptively regulate aversive memories in safe environments through extinction, a process central to exposure therapy for anxiety disorders.
Yuki Mochizuki, Asuka Joji-Nishino, Kazuo Emoto, Akira Uematsu   +3 more
doaj   +1 more source

Piezoelectric Surface Charge and Dynamic Stimulation Synergize to Promote Cardiac Myoblast Alignment and Maturation

Advanced Healthcare Materials, EarlyView.
Surface polarization of PVDF films combined with mechanical stimulation generates piezoelectric electrical cues that modulate cardiomyoblast behaviour. Non‐poled and poled PVDF substrates provide distinct electroactive microenvironments influencing cell adhesion, proliferation, and differentiation.
Rafaela M Meira, Sylvie Ribeiro, Senentxu Lanceros‐Mendez, Clarisse Ribeiro   +3 more
wiley   +1 more source

Tuning the Testicular Microenvironment for Enhancing Human Sertoli Cells Maturation and Functionality In Vitro

Advanced Healthcare Materials, EarlyView.
An in vitro testicular model is developed by generating connective tissue equivalents from human dermal fibroblast‐derived microtissues and coupling them with human Sertoli cells or human Sertoli cell spheroids. This engineered microenvironment supports Sertoli cell maturation and functionality, providing a promising platform for studying human ...
Annachiara Scalzone, Giorgia Imparato, Chiara Ausilio, Valentina Mollo, Paolo Antonio Netti   +4 more
wiley   +1 more source

VR-based cue-exposure therapy (VR-CET) versus VR-CET plus pharmacotherapy in the treatment of bulimic-type eating disorders

, 2021
. Treatment guidelines recommend antidepressant medication for bulimictype eating disorders either as an alternative to or in combination with cognitive behavioural therapy (CBT). This study compared the efficacy of two second-line treatments of patients
Andreu Gracia, Alexis, Tena, Virginia, Pla Sanjuanelo, Joana, Dakanalis, Antonios, Gómez-Tricio, Osane, Ferrer, Marta (Ferrer García), Escandón-Nagel, Neli, Ribas Sabaté, Joan, Sánchez Zaplana, Isabel, Gutiérrez Maldonado, José, Vilalta-Abella, Ferran, Riva, Giuseppe, Fernández Aranda, Fernando   +12 more
core  

Cigarette craving in virtual reality cue exposure in abstainers and relapsed smokers

Scientific Reports
Cue exposure therapy (CET) in substance-use disorders aims to reduce craving and ultimately relapse rates. Applying CET in virtual reality (VR) was proposed to increase its efficacy, as VR enables the presentation of social and environmental cues along ...
Benedikt Schröder, Agnes Kroczek, Leon O. H. Kroczek, Ann-Christine Ehlis, Anil Batra, Andreas Mühlberger   +5 more
doaj   +1 more source