Results 61 to 70 of about 58,645 (276)

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source

Attention vs. accessibility: the role of different cue types for non-canonical sentence production in German

Frontiers in Language Sciences, 2023
IntroductionThere is evidence of close links between the allocation of attention and the production of language. For instance, while speakers commonly produce active sentences when they describe an event with an agent acting on a patient, this preference
Sarah Dolscheid, Martina Penke
doaj   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Action Observation Plus Sonification. A Novel Therapeutic Protocol for Parkinson’s Patient with Freezing of Gait

Frontiers in Neurology, 2018
Freezing of gait (FoG) is a disabling symptom associated with falls, with little or no responsiveness to pharmacological treatment. Current protocols used for rehabilitation are based on the use of external sensory cues.
Susanna Mezzarobba, Susanna Mezzarobba, Susanna Mezzarobba, Michele Grassi, Lorella Pellegrini, Lorella Pellegrini, Mauro Catalan, Bjorn Kruger, Giovanni Furlanis, Paolo Manganotti, Paolo Manganotti, Paolo Bernardis   +11 more
doaj   +1 more source

Prismatic adaptation modulates oscillatory EEG correlates of motor preparation but not visual attention in healthy participants [PDF]

, 2017
Prismatic adaption (PA) has been proposed as a tool to induce neural plasticity and is used to help neglect rehabilitation. It leads to a recalibration of visuo-motor coordination during pointing as well as to after-effects on a number of sensorimotor ...
Bracco, Martina, Oliveri, Massimiliano, Thut, Gregor, Veniero, Domenica   +3 more
core   +4 more sources

YAP1::TFE3 mediates endothelial‐to‐mesenchymal plasticity in epithelioid hemangioendothelioma

Molecular Oncology, EarlyView.
The YAP1::TFE3 fusion protein drives endothelial‐to‐mesenchymal transition (EndMT) plasticity, resulting in the loss of endothelial characteristics and gain of mesenchymal‐like properties, including resistance to anoikis, increased migratory capacity, and loss of contact growth inhibition in endothelial cells.
Ant Murphy, Samuel Hartzler, Paula A. Vargas Carranza, Shyaman Jayasundara, Madison E. Yates, Nimod D. Janson, Bozhi Liu, Annaleigh Benton, Majid Kazemian, Jason A. Hanna   +9 more
wiley   +1 more source

Novel evidence for cue-based retrieval of top-down sets in spatial cueing

Frontiers in Cognition
Task cues that correctly (vs.incorrectly) inform humans about their upcoming tasks, benefit (vs. interfere with) performance because participants can use task cues to retrieve the corresponding task set, so that targets can (vs.
Christian Büsel, Christian Valuch, Christian Valuch, Rebecca Rosa Schmid, Pierre Sachse, Ulrich Ansorge   +5 more
doaj   +1 more source

Influence of hand position on the near-effect in 3D attention [PDF]

, 2008
Voluntary reorienting of attention in real depth situations is characterized by an attentional bias to locations near the viewer once attention is deployed to a spatially cued object in depth.
A. Couyoumdjian, C. J. Downing, C. L. Reed, F. Frassinetti, F. H. Previc, G. J. Andersen, H. J. Müller, J. B. Mattingley, J. Jonides, J. Theeuwes, J.-R. Duhamel, L. d. G. Gawryszewski, L. Fogassi, M. Eimer, M. Eimer, M. S. A. Graziano, N. A. Parks, P. A. Bourke, P. Atchley, P. Atchley, Patrick A. Bourke, Petra M. J. Pollux, S. Han, S. P. Tipper, S. P. Tipper   +24 more
core   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source